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Play the villain and then the policeman! After Under the Sun, Peng Guanying took on a new play. Do you think it will be a play？

In Under the Sun, Feng Xiaosheng finally won a short victory, forcing Liang Yuze to go abroad and live a self-righteous and beautiful life with Ke Ying. Even, Ke Ying invited Feng Xiaosheng to have dinner together, and their relationship made progress in stages.

Ke Ying fed Feng Xiaosheng steak, and then withdrew it when he was about to get into the mouth. Feng Xiaosheng forcibly took her arm and ate the steak. The expression of the two people’s confrontation exposed the man’s possessiveness completely.

This flowing expressive force is attributed to the actor’s acting skills: I just saw A Ying’s surprise when she was feeding, and the meat was slowly handed to her mouth to show a spoiled smile. Ke Ying took back her hand and suddenly froze, and then she was fierce and overbearing when she grabbed her hand and ate it. There was nothing wrong with Peng Guanying. Taking this drama is undoubtedly the most correct choice he has made.

"Under the Sun" has aroused a thousand waves since it first announced that the novel was made into a film and television. For no other reason, the original novel "Things in the Palm" describes that the university lecturer He Yan still tries to get rid of the clutches after being imprisoned by the male host Fu Shenxing. In order to highlight the tense relationship between men and women, there are many explicit and cruel pictures. However, it is definitely impossible to film and television all the contents, so everyone’s attitude towards TV dramas is both tense and contradictory.

Sure enough, after the TV series was broadcast, a lot of content was added and deleted in order to be more practical, and even the male master was changed into a male two. But what hasn’t changed is that the role played by Peng Guanying is still an object of resentment.

But Peng Guanying’s acting didn’t disappoint everyone. Whether it is Shen Shijie’s diabolical cruelty in the early stage or the cruel cunning of Feng Xiao’s voice in the later stage, Peng Guanying interprets it perfectly and impeccably.

Theoretically speaking, Peng Guanying is a newcomer to film and television, but unfortunately he is a newcomer of great age.

Before, everyone could only think of Princess Lanling, which co-starred with Baby Zhang a few years ago. Although his acting skills were also praised in the play, there was no follow-up resources, and he seemed to disappear from the audience’s field of vision soon.

After that, when I think of him, I can only remember that he and Zhu Yilong, who have exploded in recent years, are close friends, and Peng Meimei and Zhu Meili are active in each other’s social platforms.

However, with the online drama "The Soul of the Town", Zhu Yilong made numerous rounds, followed by other works, and soon gained a firm foothold. And "Peng Beauty" is still an invisible man.

In 2020, Zhu Yilong and Liu Shishi’s new drama "Dear Yourself" landed in iQiyi, in which Peng Guanying played love rat, who betrayed his wife. After a long time, Peng Guanying’s acting remained at a certain level, and playing against Adi often made people hate it. I wish he would disappear immediately.

Later, when he lost his way and asked his wife to forgive him, his eyes were tearful, and the audience shouted, so pitiful that I even wanted to forgive him.

Peng Guanying finally became famous.

With the update of "Under the Sun" episode by episode, Feng Xiaosheng’s temperament is also slowly changing, from revenge on Ke Ying at the beginning to hopelessly falling in love with her later, all of which are manifested in the actor’s smiles, which also tests the actor’s acting skills.

But Peng Guanying has performed well from the beginning, and he is bound to play the role well from beginning to end.

Years ago, Peng Guanying’s new play "Backlight Man" started, with Zhang Yujian as his partner, both of whom played the role of police.

The online drama "Backlight" is adapted from the novel "In the Dark" by writer Jin Shichai, which mainly tells the story of undercover policeman Xie Lanshan and portrait expert Shen Liufei fighting criminals together.

Xie Lanshan, played by Peng Guanying, and Shen Liufei, played by Zhang Yujian, met at the police academy. They established a strong affection and vowed to become excellent anti-drug policemen.

Among the posters issued at present, this group of quasi-anti-drug policemen are determined, and they are willing to hide in the dark to protect the light.

Perhaps the audience is still immersed in the vicious villain in Under the Sun, but Peng Guanying has turned over and become a policeman. With his acting skills, he is bound to perform a completely different image from Feng Xiaosheng and look forward to his new works. Wen/Hua Su

The first domestic CAR

Economic Observer Network reporter Qu Yixian After a long period of downturn, China’s innovative medicine industry has received a shot in the arm. On March 1st, 2022, CAR-T therapy of legendary creatures was officially approved by the US Food and Drug Administration (FDA) for the treatment of patients with relapsed/refractory multiple myeloma (r/r MM). This is the first domestic CAR-T cell therapy approved by FDA.

The approved CAR-T therapy is called Cilta-cel, which targets BCMA and is the second CAR-T therapy targeting BCMA in the American market. On the topic of domestic innovative drug "going out to sea", it is a sample-as early as 2017, it signed a global exclusive license and cooperation agreement with Johnson＆Johnson to jointly develop and commercialize this product.

Huang Ying, CEO and CFO of Legendary Bio, revealed that the price of Cedarchiorense in the United States is $465,000. This pricing strategy is because the pricing range of several CAR-T products that have been listed in the American market is $400,000-$470,000, and the price of the first CAR-T product with the same target is $419,500. "The premium of about 11% is a very reasonable premium, based on our differences in clinical efficacy."

According to the agreement signed at that time, in Greater China, Johnson & Johnson and Legend Bio will share the costs and benefits in a ratio of 3: 7; In other parts of the world, the agreed ratio is 5: 5.

Huang Ying said that in response to the commercialization of Cedakio Orense in the United States, Legendary Biology has recruited its own sales team in the past 6-9 months, responsible for 75-80% of large hospitals and clinics in the United States; Johnson & Johnson has a relatively large tumor sales team serving the community, and will recommend Cedactylosin to 5,500 hematology oncology specialists in the United States, hoping that these specialists can introduce patients to large local diagnosis and treatment centers and hospitals for treatment with Cedactylosin. At the same time, Johnson & Johnson will also set up a relatively small and specialized product team to promote this product to large hospitals and diagnosis and treatment centers.

Behind the first CAR-T

Sida Chiolense has attracted much attention in the research and development stage.

ASCO, the American Society of Clinical Oncology, is a great event in the medical field every year, and many heavy new drugs choose to publish the latest research data on ASCO. On the last day of ASCO in 2017, the legendary creature announced the early data of the self-developed CAR-T product LCAR-B38M (R&D code of Sida Giorense) to the pharmaceutical industry peers and experts around the world.

According to the report of Zhao Wanhong, the research organizer and deputy director of the Department of Hematology, the Second Affiliated Hospital of Xi ‘an Jiaotong University, among the 35 patients with recurrent multiple myeloma who were treated by CART, 33 (94%) got clinical remission 2 months after treatment, and the objective remission rate was 100%.

In addition, among the 19 patients who received treatment at the earliest time, 14 patients achieved strict complete remission, 1 patient achieved partial remission, and 4 patients achieved excellent partial remission. The earliest patients who received treatment have lived for more than one year, and they have reached the living state of healthy people.

It’s not imitation, nor improvement, but the exploration and innovation of a China enterprise in the "no man’s land", so when the data of Xidajiaolun match came out, everyone was surprised.

Fan Xiaohu, chief scientific officer of Legendary Biology, recalled that at that time, "it attracted global attention and (Legendary Biology) became the dark horse of China", and many people in the industry gave him feedback, and many start-ups after 2017 were encouraged.

Followed by a number of international pharmaceutical companies seeking business cooperation, after repeated communication and back tone, Legend finally joined hands with Johnson & Johnson.

In December, 2017, Legendary Bio signed an exclusive global license and cooperation agreement with Johnson & Johnson to jointly develop and commercialize Cedarchiorense. Johnson & Johnson paid Legendary Bio a down payment of $350 million and subsequent milestone payments.

By today’s standards, the down payment of $350 million is not high, but at that time, it was the best condition for China pharmaceutical companies to record the largest amount of down payment for foreign patent authorization and cooperation.

Regarding the cooperation between the two parties, Huang Ying said that Legend’s cooperation with Johnson & Johnson has strengthened the legendary creature’s ability in the process of R&D and registration of Sida Chiolense. From early R&D to late R&D, including clinical, commercial production, GMP production, compliance registration and other processes, the legendary creature’s team actively participated in the whole process, and also cultivated their own ability in the process of learning from Johnson & Johnson.

However, this cooperation model also has shortcomings, "the whole cycle is very long and the investment is very, very large", because Legend’s investment in the American market is as 50-50 as Johnson & Johnson’s, which is a relatively large financial burden for legendary creatures of innovative pharmaceutical companies.

multiple myeloma

Cedactylorense is a chimeric antigen receptor (CAR) T-cell immunotherapy with two single-domain antibodies targeting B-cell mature antigen (BCMA), which is administered by one-time infusion.

Cedactylorense has been approved by FDA to treat patients with relapsed or refractory multiple myeloma, who have received four or more treatments in the past, including proteasome inhibitors, immunomodulators and anti-CD38 monoclonal antibodies.

Multiple myeloma is considered as an incurable hematological tumor, and it is a malignant disease caused by excessive proliferation of plasma cells in bone marrow. Most patients relapse after initial treatment, and the prognosis is not good after receiving the main drugs such as immunomodulator, proteasome inhibitor and anti-CD38 antibody.

According to the American Cancer Society, in 2022, more than 34,000 people in the United States will be diagnosed with multiple myeloma, and more than 12,000 people will die.

Sundar Jagannath, a professor of hematology oncology at Mount Sinai Medical College and a principal investigator of CARTITUTE-1, said that the treatment process of most patients with multiple myeloma is a cycle of continuous remission and recurrence, and only a few patients get deep remission after last-line treatment. "That’s why I am very excited about the results of CARTITUDE-1 study, which shows that Sidakiorense can provide deep and lasting remission and long-term no treatment even after multi-line treatment.

The approval of Sida Chiolense is not based on the data reported in ASCO in the United States in 2017, but on the key data of a CARTITUDE-1 study. CARTITUDE-1 is an ongoing phase 1b/2, open-label, one-arm, multi-center study, with 100% patients from the United States.

In CARTITUDE-1 study, 97 patients with R/R MM experienced deep and lasting remission, with an overall remission rate (ORR) of 98% and a strict complete response (sCR) of 78%. During the median follow-up of 18 months, the median remission duration (DOR) was 21.8 months.

The incidence of multiple myeloma in China is 2-3 patients per 100,000 people. Although it is lower than that of Caucasian and African people, there are considerable unmet clinical needs because of its large base.

Regarding the listing of this product in China, according to the latest communication between Legend Bio and National Medical Products Administration Drug Evaluation Center (CDE), some patients need to be re-enrolled in clinical trials. Huang Ying said that she would keep in touch with CDE during this period.

Enlightenment of "going out to sea"

The research and development cost of innovative drugs is extremely high, and with the implementation of policies such as domestic centralized procurement and medical insurance negotiation, it is almost impossible to recover the research and development cost in a short period of time after the innovative drugs are listed. Under the circumstance that the cost cannot be covered by a single market, it has become an industry consensus to "go out to sea" and develop the international market.

Compared with biopharmaceuticals, the R&D and production of CAR-T are more complicated. The "Going to Sea" of Sidaji Orense is another innovative drug listed in the United States after Zebutini of Baekje Shenzhou.

But before that, in February, Cinda Bio’s PD-1 product Cindilizumab had just been defeated in the United States. In view of the passing of cindilizumab, FDA experts mainly pay attention to three issues: first, whether the control group selected in clinical trials is reasonable; Second, the clinical trial is only done in China population, is it applicable to American patients? Thirdly, it mainly studies whether the design of the terminal is reasonable.

In Huang Ying’s view, since China joined ICH, the regulatory standards of National Medical Products Administration, China are basically the same as those of FDA, focusing on efficacy and product safety evaluation. "There is not much difference between FDA and CDE standards. There may be slight differences in the number of patients enrolled, the length of follow-up, GMP, production process, quality control and other issues, but for a new drug, efficacy and safety are the gold standards."

However, Huang Ying also believes that for enterprises, there are also places that need special attention, such as whether the experimental population can represent the situation of American patients in the real world when doing clinical trials. In the United States, the Asian population is about 5%. It is difficult to apply for approval with the data of 100% Asian population or Chinese.

One more thing, does the control group designed in clinical trials use placebo or the best treatment standard already available in the market? "CDE has also issued guidelines. Even if you do clinical trials in China in the future, you can’t just use placebos, but you need to use the best standard drugs in the industry as the control standard." Huang Ying said.

Fan Xiaohu, on the other hand, thinks that biomedical enterprises in China should not worry about policy vacillation and payment all day long, or whether the door of the FDA in the United States will be closed. "These don’t need to be overly worried and interpreted, but (what is needed) do their own thing well and do scientific and technological innovation well."

Reporting/feedback

The main force of soda ash in the chemical sector rose by nearly 3%

name of commodity spot price treaty futures price Basis difference Basis rate natural rubber 17010 2501 18005 -995 -5.85% pulp 6240 2501 5770 470 7.53% butadiene rubber 15030 2501 13610 1420 9.45% pta 4915 2501 4882 33 0.67% glass 1256 2501 1308 fifty-two 3.82% methyl alcohol 2470 2501 2483 minus thirteen -0.53% urea 2188.75 2501 1785 403 18.41% soda ash 1670 2501 1482 188 11.26% Polyester staple fiber 7226.67 2502 6946 280 3.87% PX 7300 2501 6796 504 6.90% caustic soda 1022 2501 2631 562 17.60% Bottle slice 6170 2503 6192 -22 -0.36% polyvinyl chloride 5216 2501 5335 -119 -2.28% polyethylene 8596.67 2501 8223 373 4.34% polypropylene 7585.71 2501 7436 149 1.96% glycol 4608.33 2501 4579 29 0.63% styrene 8860 2412 8310 550 6.21% No.20 glue 14457 2501 14300 157 1.09%

Domestic prices keep running smoothly-a perspective of CPI and PPI data in the first quarter

Xinhua News Agency, Beijing, April 11th Title: Domestic prices keep running smoothly-a perspective of CPI and PPI data in the first quarter

Xinhua News Agency reporter Wei Yukun and Shui Jinchen

Since the beginning of this year, China’s prices have maintained a stable operation. The National Bureau of Statistics released data on the 11th. In the first quarter, the national consumer price index (CPI) rose by 1.3% on average compared with the same period of last year, and the national industrial producer ex-factory price index (PPI) dropped by 1.6% compared with the same period of last year, which continued to be an important "stabilizer" for global prices.

CPI runs in a reasonable range

Stabilizing prices is an important task to do a good job in this year’s economic work. This year’s government work report will set the annual increase in consumer prices at around 3%.

The latest data shows that in the first quarter, CPI continued to operate in a reasonable range, and the monthly increase was lower than the expected target of around 3%.

Dong Lijuan, chief statistician of the Urban Department of the National Bureau of Statistics, said that in January, due to factors such as the Spring Festival effect and the optimization and adjustment of epidemic prevention and control policies, CPI rose by 2.1% year-on-year, an increase of 0.3 percentage points over the previous month; In February, affected by factors such as falling consumer demand after the holiday and sufficient market supply, the year-on-year increase of CPI dropped by 1.1 percentage points compared with the previous month; In March, production and life continued to recover, and the consumer market was fully supplied. CPI rose by 0.7% year-on-year, and the growth rate dropped by 0.3 percentage points from last month.

In China’s CPI "basket" goods, food accounts for a relatively high proportion. Since the beginning of this year, the increase in food prices has continued to fall, from 6.2% in January to 2.4% in March.

From the ring comparison, the price of food changed from 2.8% in January to 1.4% in March. Dong Lijuan analyzed that in March, due to the abundant stock and the decline in consumer demand, pork prices decreased by 4.2% month-on-month; The price of fresh vegetables decreased by 7.2% month-on-month, which was 2.8 percentage points higher than that of last month.

"Vegetable production is greatly affected by meteorological conditions. Adequate sunshine and rising temperature in March are conducive to improving the growth rate of vegetables, resulting in an increase in the output of some vegetables and a downward price. In addition, due to the’ cold spring’ weather in the producing areas, the listing period of vegetables has been postponed, and the prices of lettuce, cauliflower and other varieties have fluctuated frequently. " Zhang Jing, chief analyst of the vegetable market analysis and early warning team of the Ministry of Agriculture and Rural Affairs, said.

The increase in non-food prices has declined. In March, non-food prices rose by 0.3% year-on-year, and the growth rate dropped by 0.3 percentage points from the previous month. In non-food, service prices rose by 0.8% year-on-year, with an increase of 0.2 percentage points over the previous month; The price of industrial consumer goods changed from 0.5% last month to 0.8%.

"Since the beginning of this year, the year-on-year increase of China’s core CPI has been fluctuating in the range of around 1%, which shows that the consumer prices of industrial consumer goods and services in China have remained stable." Wang Likun, an associate researcher at the Institute of Market Economy of the State Council Development Research Center, said.

PPI growth continued to fall.

Affected by factors such as the high comparative base in the same period of last year, the overall price of industrial products in China continued to decline. In the first quarter, PPI decreased by 1.6% year-on-year, including a decrease of 2.5% in March, which was 1.1 percentage points higher than that in the previous month.

From the ring comparison, in January, due to the fluctuation of international crude oil prices and the downward trend of domestic coal prices, the PPI decreased by 0.4% from the previous month. In February, the production recovery of industrial enterprises accelerated, the market demand improved, and the PPI turned flat. In March, due to the accelerated recovery of the domestic economy and the price trend of some commodities in the international market, the PPI remained flat.

Dong Lijuan analyzed that in March, domestic production and market demand continued to improve, key projects were accelerated, and the prices of steel, cement and other industries increased from the previous month. Among them, the prices of ferrous metal smelting and rolling processing industries and cement manufacturing all increased by 1.3% from the previous month. International input factors have driven down the prices of domestic oil and non-ferrous metals-related industries, among which the prices of oil and natural gas mining industry decreased by 0.9% month-on-month, and the prices of oil, coal and other fuel processing industries decreased by 0.4%. Affected by seasonal factors such as rising temperature, the demand for coal has decreased, and the price of coal mining and washing industry has dropped by 1.2%.

"The continuous decline in PPI growth will help improve the profit structure of upstream and downstream industries, ease the cost pressure of manufacturing enterprises in the middle and lower reaches, and stimulate the vitality of micro-subjects." Wang Likun said.

There is a solid foundation for keeping prices running smoothly.

Prices are related to economic operation and affect people’s lives. Experts said that with the gradual improvement of domestic demand, the supporting role for related prices will be enhanced, and the influence of international input factors still exists, and there is some pressure to stabilize prices. However, judging from the trend of the whole year, it still has a solid foundation to maintain the stable operation of prices.

Fu Linghui, a spokesperson for the National Bureau of Statistics, said that China’s grain production has maintained growth, and the grain output has been stable at more than 1.3 trillion Jin for eight consecutive years, and the inventory is relatively abundant; Pork production capacity is at a reasonable level and does not have the conditions for a sharp increase; Energy prices are stable. Last year, China effectively released advanced coal production capacity, and the energy self-sufficiency rate was above 80%. In recent years, the production of oil and natural gas has increased significantly, which is conducive to stabilizing energy prices.

The National Development and Reform Commission has made it clear that we should make overall plans to increase employment and income, and strengthen the supply and price stability of key commodities; The National Energy Administration requires that we do our best to ensure the supply and price stability of natural gas this year to ensure the demand for gas for people’s livelihood; Zunyi, Guizhou, established a unified "white list" system to guarantee supply, strengthened the mechanism of joint guarantee and supply, and ensured a strong and orderly supply of "rice bags" … Recently, all relevant departments and localities have made overall plans to ensure supply and stabilize prices.

Key enterprises have increased efforts to ensure supply and price stability, and have sufficient stocks. For example, Beijing Xinfadi Market will expand the "through train" to cover cities and build a green channel for featured agricultural products to enter Beijing; Meituan buys vegetables on the early-adopter channel of spring vegetables. Toona sinensis, shepherd’s purse, spring bamboo shoots and other fresh spring vegetables are well supplied. Cheap food markets and super discount channels are updated every day, and the prices remain generally stable.

"Looking forward to the whole year, China’s industrial and agricultural products and services are well supplied, production and marketing are smoothly connected, the market order is good, and the overall economic recovery trend will gradually appear in prices. It is expected that the overall price level will generally operate in a reasonable range." Guo Liyan, director of the Comprehensive Situation Research Office of China Macroeconomic Research Institute, said.

Attention, all researchers! The State Council, this document will give you more autonomy, raise funds and reduce approval!

"Now we have to’ decentralize’ more thoroughly and further mobilize the enthusiasm of the majority of scientific researchers!" Premier Li Keqiang on July 4th.The State Council Standing CommitteeIt says.

A few days ago, the State Council issuedNotice on Several Measures to Optimize Scientific Research Management and Improve Scientific Research PerformanceIn the future, researchers will have greater autonomy in how to do scientific research and how to spend funds. How to specify it, the Chinese government website (WeChat ID: zhengfu) and the the State Council client will take you to see it together-

First, scientific researchers have greater decision-making power over the technical route.

■ Reporting period of scientific research projects: based onTechnical route proposed by scientific researchersDemonstrate for the Lord

■ During the implementation of scientific research projects: scientific researchers can, on the premise that the research direction remains unchanged and the reporting indicators are not lowered.Independently adjust the research scheme and technical route, reported to the project management professional institutions for the record.

■ The person in charge of a scientific research project may, according to the needs of the project, comply with regulations.Set up a scientific research team independently, and make corresponding adjustments according to the progress of project implementation.

Two, scientific research units have autonomy in the management and use of scientific research project funds.

■ In addition to the equipment cost, the direct cost,All other subjects’ cost adjustment rights are delegated to the project undertaker.

■ For the project funds entrusted by enterprises or other social organizations,Incorporate into the unified financial management of the unit., managed and used by the project undertaker according to the requirements of the entrusting party or the contract.

■ Universities and research institutes should simplify the procurement process of scientific research instruments and equipment, and adopt the equipment and consumables urgently needed for scientific research.Do special things and do them on call.The procurement mechanism can shorten the procurement cycle without bidding procedures; For the exclusive agent or production of instruments and equipment, according to the procedures to determine the adoption.Single source procurementEqual mode

First, increase the salary incentives for scientific researchers who undertake key technical research tasks in key areas of the country.

■ For team leaders (leading scientists/chief scientists, technical chief engineers, model chief engineers, chief commanders, chief executives, etc.) who undertake tasks full-time and full-time, as well as imported high-end talents, it is implemented.One policy, list management and annual salary system

■ The performance expenditure extracted by the unit from the indirect cost of the key technical research projects in key areas of the country should be paid to those who undertake the task.Young and middle-aged scientific research backbone tilt

■ Increase the incentives for scientific research personnel in universities, research institutes and state-owned enterprises to transform their scientific and technological achievements into equity, and the scientific and technological achievements obtained by scientific research personnel.The converted cash reward is included in the total performance salary of the unit in the current year., but not limited by the total amount, not included in the total base.

Two, to carry out a pilot program to simplify the budget of scientific research projects.

■ In addition to the equipment cost, the direct cost of the project,Other expenses only provide basic calculation instructions, not details.

■ furtherStreamline and merge other direct expense accounts.

■ All project management professional institutions should simplify the budget preparation requirements of relevant scientific research projects.Streamline descriptions and reports

Three, to expand the autonomy of the use of scientific research funds.

■ Pilot units are allowed to steadily support scientific research funds from basic scientific research business expenses and special funds for strategic pilot science and technology of Chinese Academy of Sciences.Withdraw no more than 20% as incentive funds.

■ The scope and standard of use of incentive funds shall be decided by the pilot unit independently within the total performance pay, and publicized within the unit.

■ Intelligence-intensive projects such as basic research, software development and integrated circuit design with low dependence on test equipment and low consumption of experimental materials.Increase the proportion of indirect funds30% for the part below 5 million yuan, 25% for the part between 5 million yuan and 10 million yuan and 20% for the part above 10 million yuan.

■ YesPure theoretical basic research projects such as mathematics, can further adjust the proportion of indirect funds according to the actual situation.

■ The use of indirect funds should be tilted towards teams and individuals with outstanding innovation performance.

Four, to carry out scientific research institutions to support the pilot classification.

For basic frontier research institutions, increase regular funding and other stable support,Appropriately raise the subsidy standard for personnel funds.To ensure reasonable salary and treatment, so that researchers can devote themselves to basic research for a long time.

First, simplify the declaration and process management of scientific research projects

S gradually implement the national science and technology plan annual guide release system on a regular basis, and the guide in advance online publicity, strengthen the project check,Avoid duplicate declaration, increase the preparation time for scientific research personnel to declare

■ Streamline the reporting requirements for scientific research projects,Reduce unnecessary application materials.

■ Implement "milestone" management for key nodes,Reduce all kinds of evaluation, inspection, spot check, audit and other activities during the implementation cycle of scientific research projects.

■ Free exploration basic research projects and implementation cycleFor projects under three years, the self-management of the undertaking unit is the main task., generally do not carry out process inspection.

Two, the merger of financial acceptance and technical acceptance

A one-time comprehensive performance evaluation will be conducted by the professional organization of project management in strict accordance with the task book at the end of the project implementation, and separate financial acceptance and technical acceptance will no longer be carried out.

Three, the implementation of "materials submitted at a time"

■ Integrate the work of science and technology management and the related links of material submission of plan management to realizeMulti-purpose of one meter

■ All materials that have been provided by the national science and technology management information system or have been requested,Repeated provision shall not be required.

■ Simplify statements and processes, speed up the establishment and improvement of academic assistant and financial assistant systems,It is allowed to purchase professional services such as accounting, the scientific research personnel from statements, reimbursement and other specific affairs.

Fourth, avoid repeated multi-head inspection

■ Make a unified annual supervision and inspection plan, and carry out joint inspections at relatively concentrated time to avoid the same project in the same year.Repeated inspection and multi-head inspection

■ Explore the implementation of "double random and open" inspection methods, make full use of information technologies such as big data to improve the efficiency of supervision and inspection, and implement information sharing and mutual recognition of supervision and inspection results.Minimize interference with scientific research activities.

National Bureau of Statistics： In 2022, the operating income of cultural and related industries above designated size increased by 0.9%.

Cctv newsAccording to the website of the National Bureau of Statistics, according to a survey of 69,000 cultural and related industrial enterprises above designated size (hereinafter referred to as "cultural enterprises"), in 2022, cultural enterprises realized an operating income of 12,180.5 billion yuan, an increase of 0.9% over the previous year.

　　In terms of formats, the operating income of 16 industry subcategories with obvious characteristics of new cultural formats reached 4,386 billion yuan, up 5.3% over the previous year and 4.4 percentage points faster than that of all cultural enterprises above designated size.

　　By industry category, the operating income of news information service was 1,446.4 billion yuan, up by 3.3% over the previous year. Content creation and production reached 2,616.8 billion yuan, an increase of 3.4%; Creative design service was 1,948.6 billion yuan, down by 0.2%; Cultural communication channels were 1,312.8 billion yuan, down by 1.0%; Cultural investment operation was 50.4 billion yuan, an increase of 3.2%; Cultural entertainment and leisure services reached 114.1 billion yuan, down by 14.7%; Cultural auxiliary production and intermediary services were 1,651.6 billion yuan, down by 0.6%; The production of cultural equipment was 690.4 billion yuan, up by 2.1%; The output of cultural consumption terminals was 2,349.4 billion yuan, an increase of 0.3%.

　　In terms of industrial types, the operating income of cultural manufacturing industry was 4,478.1 billion yuan, an increase of 1.2% over the previous year; Cultural wholesale and retail trade was 1,937.6 billion yuan, down by 1.2%; The cultural service industry was 5,764.8 billion yuan, an increase of 1.4%.

　　In terms of fields, the operating income of cultural core areas [3] was 7,489.1 billion yuan, an increase of 1.3% over the previous year; Cultural-related fields reached 4,691.4 billion yuan, an increase of 0.2%.

　　In terms of regions, the eastern region realized an operating income of 9,171.4 billion yuan, an increase of 0.1% over the previous year; The central region was 1,826.9 billion yuan, an increase of 5.8%; 1,079.3 billion yuan in the western region, an increase of 0.5%; Northeast China was 102.9 billion yuan, down by 1.0%.

Chinese aunt shot again？ With the increase of 8 yuan money per gram, the scene of snapping up gold is still ＂good hi yo＂!

　　CCTV News:At the end of the year and the beginning of the year, many consumers will buy new year gifts for their families, and gold jewelry is one of the more popular choices. Recently, Beijing’s gold jewelry sales have entered a peak period. Next, we immediately connected with our reporter Tang Xiaotong who is in Beijing. What are the most popular styles of gold jewelry this year? What is the sales volume?

　　Reporter Tang Xiaotong: I’m at the Caibai Market in Beijing. Since the beginning of this year, the international gold price has been constantly touching high. Affected by this, the prices of gold and jewelry in major gold shops in Beijing have also increased accordingly. Now the price of pure gold 999 has risen from 345 yuan per gram to 353 yuan. Although the price has gone up, it has not affected consumers’ enthusiasm for buying gold jewelry years ago. It can be seen that there are many people behind me now. It is understood that since mid-January, the number of consumers who come to buy has gradually increased. So what products do you like this year? Let’s ask a consumer.

　　Consumer: it’s for my daughter-in-law. I want to make a good start. (What’s the budget for buying gold ornaments this year? ) Maybe five or six thousand. Now that the living standard has improved, life is getting better.

　　Reporter Tang Xiaotong: We can see the consumers who buy gold jewelry, the middle-aged and elderly people in the past, and now more and more young consumers are also very fond of it. In order to cater to their needs, many merchants now spend a lot of thoughts on the design of gold jewelry products, among which one "transit bead" is very popular and can be said to be the explosion here. So in terms of design, are there any tricks this year?

　　Li Gen, designer of Beijing Caishikou Department Store: This year, we adjusted the craft on the original basis, so that the color of the whole gold ornament will be richer. In addition, the shape has also been adjusted. Last year, the design of pig’s head gold ornaments was round on the back, but consumers are prone to reverse when wearing them. This year, the design is smoother. In addition, this year we added the element of "Fu", which has different meanings and is more auspicious. Even if it is reversed when worn, it will not affect the beauty of wearing.

　　Reporter Tang Xiaotong: In recent years, hard gold has been welcomed by consumers. What are the reasons?

　　Li Gen, designer of Beijing Caishikou Department Store: Hard gold can be visually bigger on the basis of the same weight.

　　Reporter Tang Xiaotong: How much will the price difference be?

　　Li Gen, designer of Beijing Caishikou Department Store: For example, generally speaking, gold ornaments like this little pig’s head are made of about 1 gram of hard gold, but it is about 3 grams made by traditional techniques.

counselor

Hired by CCTV International Network Co., Ltd.deheng law officesAs a perennial legal adviser.
　　Deheng law offices is one of the largest comprehensive law firms in the world. Founded in 1993, it was formerly known as the China Lawyers Affairs Center of the Ministry of Justice, and changed its name in 1995.
　　With the idea of "Virtue in the World, Faithfulness in Nature", Deheng initiated the global partnership system in China. In addition to its Beijing headquarters, Deheng has set up 24 domestic branches in Shanghai, Guangzhou and Shenzhen, 5 overseas branches in new york, Paris and Dubai, and established cooperative relations with more than 150 law firms around the world.
　　Adhering to the tenet of "diligence, dedication and pursuit of justice", Deheng is committed to providing high-quality and efficient legal services to our clients, completing a series of major legal service projects with far-reaching social impact, creating many honors in the field of legal services in China and around the world, and winning wide acclaim from clients around the world.
　　Deheng law offices Website: www.dehenglaw.com
　　Address: 12th Floor, Block B, Fukai Mansion, No.19 Financial Street, Xicheng District, Beijing, China, 100033.

　　Email: zhangkai@dehenglaw.com.

How about Stallone Statham’s return without Jet Li’s ＂The Expendables 4＂

Special feature of 1905 film network "This is my last day in the crew of The Expendables, and it’s time to say goodbye to this series!" In the behind-the-scenes tidbits, 77-year-old Stallone tearfully bid farewell to the "Death Squad" series that has been with him for 13 years.

This video has won more than one million praises, and netizens have cherished the lost youth in the comment area and paid tribute to the former action superstars.

However, in sharp contrast to this massive "sentimental killing", the box office and word-of-mouth of "The Expendables 4: The Final Chapter" are far below expectations.

After five days of release, the box office failed to break through 100 million yuan, and the Douban score was only 5.0 points. No accident will create a new low in the series.Netizen commented: "The former superstars are really old!" "100 minutes of muscle bombing, some aesthetic fatigue" and "the so-called final chapter is just a dog’s tail harvesting the box office."

In 13 years and 4 movies, why is this classic tough guy action series that attracts global action superstars no longer popular? Time has passed, will you pay for this wave of feelings?

The death squads 4Why can’t it be sold?

Stallone, Jason Statham, Jet Li, Schwarzenegger, Bruce Willis, Jean-Claude Van Damme, Dolph Lundgren, randy couture … The super lineup assembled by global action stars has always been the biggest selling point of the "Expendables" series.

However, in the past nine years since the third part, with the growth of age and the change of situation, it is no longer easy to assemble the original team. Schwarzenegger and Jet Li announced their withdrawal, and Stallone once gave up his intention, and finally struggled to play, but only Jason Statham, Dolph Lundgren and randy couture were left among his comrades who fought from the first film.

Although the newly-joined 50 cents and Southeast Asian stars such as Tony Jaa and iko uwais have a certain reputation, their appeal is obviously worse than a grade, which makes this "The Expendables 4" not star-studded enough in the lineup. Jet Li’s withdrawal, in particular, undoubtedly greatly reduced the expectations of China fans.

Let’s look at this series of housekeeping skills — — Action play. Without special effects body double, the hormone-bursting action drama has always been a magic weapon for the "death squads". This film also invited a family class to act as an action guide, and directly played the slogan "Men want to fight", which can be described as simple and rude.

However, from the whole film, the action design is indeed the biggest highlight, but it can’t completely satisfy the fans. First of all, Stallone, the "soul figure", was seriously short of playing time. After the opening fierce battle, he hurried off the production line, making the second half of the film a solo show of Jason Statham.

Several brand-new members of the death squad lack the signature movements and personal characteristics of their predecessors, and even the performance space of Tony Jaa, the champion of boxing, is very limited, which fails to fully display his skills.

Close combat, which is essential in the first three movies, is also pitiful in this one. Only Jason finally fought iko uwais’s cold weapon, which was regarded as the highlight of the whole play, and found the familiar taste. In the rest of the time, you can never use a gun, so the excitement of boxing to meat and blood is naturally greatly reduced.

In addition, although there are many necessary action elements in Hollywood commercial films, such as gun battle, racing and explosion, and the design of motorcycle gun battle and freighter drift has also been innovated, the repeated bombing of gatling, grenades, rocket launchers and nuclear bombs has brought more aesthetic fatigue.

In addition, the special effects of the film are relatively rough. Under the limited budget, most of the scenes are filmed in the shed, which naturally lacks the real texture and is difficult to satisfy the aesthetics and tastes of the current audience.

If there is any merit in action drama, the plot logic can’t stand scrutiny at all. It can be said that fighting for fighting and bombing for bombing, villains are bluffing, decency will never die, and women are still vase characters, full of routines.

Generally speaking, "The Expendables 4" is a sequel to the sequel, without the climax of the final chapter of the series, only the self-repetition of the dog’s tail and the mink. And China audience has already passed the stage of not watching the plot, only paying for the stars and big scenes, so the box office is naturally cold.

What are the feelings of the "Death Squad" series?

From birth to ending, from in-play to out-of-play, Stallone is undoubtedly the soul of the "death squad".All this stems from an idea of Stallone when he was filming the Indian film "Unbelievable Love": he wanted to shoot a film dominated by guns, starring tough guys from all walks of life.

He made a list of more than 20 people and contacted them one by one. I didn’t expect most of them to agree to play soon, which gave the "big brother" enough face.

Among them, the most important thing is undoubtedly Schwarzenegger’s joining. At that time, he had not received the drama for many years because of his political career. This was also his first cooperation with Stallone. "I think we must remove all obstacles to fulfill this wish. After all, we can spend less and less time on the screen. This movie is a gift that Stallone and I brought to the fans."

Jet Li once recalled the participation process: Stallone wanted to cooperate with him as early as 1994, but he never made it. It was not until 2009 that he saw the script of "The Expendables" that he agreed to play. "It is good to put everyone in the 70s and 80s together to make a movie!"

Indeed, paying tribute to the action movies and action superstars in the 1980s is exactly the original intention of Stallone in preparing this series.He once said that he hated computer special effects and wanted to make a movie with his brain and muscles. "I want to find a group of real action actors, not fake gestures."

Stallone also tailored the iconic moves for these tough guys, such as Long Geer is karate, Stanson is flying knife, and Jet Li is close combat. Schwarzenegger recreated the shape and lines of the shotgun in Terminator, and he himself was a revolver.

In this way, "top lineup+hardcore action" has become a magic weapon for the death squad IP. Whether it is the classic action scene of superstar confrontation or the firearms and equipment at the arsenal level, action fans are relished.

The series has also launched new works at the rate of "strike while the iron is hot" every two years. From 2010 to 2014, three films were released in succession, and the global box office reached 800 million US dollars.

Among them, the performance of China market is particularly eye-catching: the first one is 216 million, the second one is 331 million, and the third one is 452 million, totaling 1 billion RMB. The third one accounts for one third of the global box office, making it the largest ticket warehouse.

Presumably, this is also an important reason why The Expendables 4 chose mainland China to be released in North America one week ahead of schedule.

For the China audience who grew up watching Hollywood classic action movies such as The First Blood, The Terminator and Rocky, behind the same frame of these actors is a golden age. At the same time, they finally got the movie ticket that they owed for a long time.

However, as the sequel is repeated, the audience is gradually tired of aesthetics. "The Expendables 3" has already shown signs of decline, with a box office of only 39.32 million in North America, which also makes it difficult to advance the fourth film.

Now nine years later, Stallone is 77 years old, Long Geer is 66, randy couture is 60, and even Jason Statham is 56.

The former audience is no longer young, and the post-80 s who love them are no longer the main force of watching movies.

Tough guys will eventually get old, and youth will always disappear. The Expendables 4 seems to prove that some classics are destined to stay in memory.

Guangzhou Auto Show Preview ｜ Those models equipped with 4C and 5C rechargeable battery technology

"Charge for five minutes, talk for two hours". In the past, we could only see such a slogan in some mobile phone advertisements. With the continuous progress of battery technology in new energy vehicles, 4C and 5C batteries with "charge for ten minutes and battery life of 400 kilometers" will also meet us soon. As the Guangzhou Auto Show is about to open, this issue will take stock of the new models equipped with 4C and 5C battery technology.

So, what are 4C and 5C batteries? First, let’s find out the meaning of the letter "C". The current value required for the battery to discharge its rated capacity within a specified time can be expressed by the numerical value of the rated capacity (C), which is equal to the multiple of the rated capacity of the battery in data value, and the unit is ampere (A). For example, when the battery capacity of a car is 100Ah, the discharge current of 1C is 100 A; The discharge current of 2C is 200A, so 4C has reached 400A A.. Similarly, high discharge rate also means the improvement of battery charging ability, which is naturally of great concern to consumers. According to the calculation of power = current× voltage, on the basis of 800V high-voltage platform widely used in high-discharge rate battery models, if a battery with a capacity of 100Ah has a discharge rate of 4C, it can input a charging current of 100×4=400A, and then multiply it by 800V, which is the charging power of 320kW per hour. In other words, it only takes ten minutes to charge, and it can charge about 53.3 kWh, which brings considerable power.

Qi Rui Xing Tu Xing Ji Yuan ES: Contemporary Amperex Technology Co., Limited 4C Shenxing Supercharged Battery

"Charging for 10 minutes, battery life for 400 kilometers" in front of the article is the propaganda slogan played by Qixing Road Xingyu Era ES. Based on E0X high-performance electric platform, Star Road Star Era ES is the first China brand car with 800V high-voltage platform for mass production. It is equipped with 4C Shenxing rechargeable battery first launched by Contemporary Amperex Technology Co., Limited, and Contemporary Amperex Technology Co., Limited also characterized it as "the world’s first 4C rechargeable battery made of Ferrous lithium phosphate materials and capable of mass production". Because the positive electrode of the battery is based on Ferrous lithium phosphate material system, the cost of Shenxing 4C rechargeable battery is greatly reduced compared with that of ternary fast rechargeable battery.

Previously, Star Road Star Era ES has started blind subscription, and the blind subscription price range is 260,000-360,000 yuan.

Extreme Krypton 001 FR and Extreme Krypton 007: Contemporary Amperex Technology Co., Limited 4C Kirin Battery

Based on Krypton 001, Krypton 001 FR is a pure electric hunting coupe with performance exceeding one million fuel supercars. It is equipped with four wheels and four motors, with a maximum power of 1300Ps and a zero acceleration of 2.02 seconds. The price is only 769,000 yuan. In terms of appearance, the new car adopts a set of sporty encirclement. The front lip, the side lip and the tail wing are all made of carbon fiber, and the hub is also made of high-performance sports tires. From the face value, it is a very strong sports beast. The appearance of extreme Krypton 001 FR has further deepened the sports performance genes of extreme Krypton brand.

In terms of battery, the Krypton 001 FR is equipped with a 100kWh Kirin battery, with a maximum charging rate of 4C, which can charge the battery from 10% to 80% in just 15 minutes.

Although the car Krypton 001 FR is not limited to purchase, it is limited to 99 units per month. If we can’t grab it, we can take a look at the next one.

If Krypton 001 FR is an experimental product of 4C Kirin battery, then Krypton 007, the first car under the Krypton brand, is a sign that Krypton really starts to charge 4C quickly.

As the first medium-sized car owned by Krypton, Krypton 007 is built on PMA2+ platform under SEA architecture, equipped with 800V electrical architecture, Kirin battery, Snapdragon 8295 chip and three laser radars. The news about Krypton 007 is still limited, but with the support of PMA2+ platform and 800V high-voltage electrical architecture, the maximum charging power of Krypton 001 equipped with Kirin 4C battery is expected to reach 400kW.

The price range of the new car is expected to be about 250,000-300,000 yuan, and it will be officially unveiled at the Guangzhou Auto Show, which opened on November 17, and the pre-sale will be started simultaneously.

Wenjie M9: Contemporary Amperex Technology Co., Limited 4C Kirin Battery

On September 25th, 2023, Huawei held a new product launch conference in autumn. Yu Chengdong, chairman of Huawei, announced that the M9, the flagship SUV of Panoramic Wisdom, would be released in December 2023.

The M9 is positioned as a D-class luxury SUV. The length, width and height of the new car are 5230mm×1999mm×1800mm respectively, and the wheelbase is 3110mm. Wenjie M9 is equipped with Huawei’s advanced intelligent assisted driving system and HarmonyOS Harmony 4.0 cockpit. In terms of power, the M9 adopts a 1.5T dual-motor extended-range hybrid system and a dual-motor four-wheel drive pure electric power system. In terms of battery, the extended range version is equipped with Contemporary Amperex Technology Co., Limited battery pack, with a battery capacity of 40kWh and a pure electric cruising range of 175km；; The pure electric version is equipped with Contemporary Amperex Technology Co., Limited 4C Kirin battery, with a capacity of 97kWh and a cruising range of 630km, and supports 800V ultra-fast charging technology.

Hechuang V09: Juwan Technology 4C Fast Charging Battery

Hechuang Automobile is a new energy premium brand jointly invested by Zhujiang Investment Management Group and Guangzhou Automobile Group. It has launched three models: Hechuang 007, Hechuang Z03 and Hechuang A06. On October 13th, Hechuang Automobile’s first pure electric luxury MPV, Hechuang V09, was officially launched and delivered simultaneously. There are five versions of the new car: Deluxe Edition 620, Honor Edition 620, Honor Edition Overcharged Edition 620, Honor Edition 762 and Flagship Edition 762. The standard cruising range of CLTC is 620km and 762km respectively, and the official suggested retail price is 318,800-438,800 yuan.

Hechuang V09 comes standard with 800V high-voltage silicon carbide platform. Among them, Hechuang V09 "Honor Edition Overcharged 620" version is equipped with XFC rechargeable battery customized by Juwan Technology Research. The official said that the peak fast charging power is as high as 410kW, and the charging efficiency has reached 4C level.

Tucki X9: Contemporary Amperex Technology Co., Limited Kirin 4C Battery

Tucki X9 is Xpeng Motors’s new flagship MPV. He Xiaopeng once said that Xpeng Motors will use this model to open the "young" MPV market. Indeed, judging from the design of Tucki X9, the route taken by Tucki X9 is really different from other pure electric luxury MPVs, and the contour lines of the front and rear of the new car are more dynamic.

Coupled with Tucki’s proud advanced intelligent driving and rear wheel steering blessing, it seems that Tucki X9 will focus more on the main driving.

As for the battery, Tucki X9, like Tucki G9 and G6 before, is built by Tucki’s whirlwind architecture, and also adopts 800V high-voltage platform. The battery is ternary lithium-ion battery from Zhongchuang Singapore Airlines. According to speculation, the 4C battery technology provided by Tucki G9 should also appear on Tucki X9, and this 4C battery is still from Kirin 4C battery in Contemporary Amperex Technology Co., Limited. On the 2023 Tucki G9, the Kirin 4C battery appeared as an optional package. On the 2024 Tucki G9, the 4C battery option package disappeared. Generally speaking, whether Tucki X9′ s energy-supplementing efficiency can reach 4C still needs further information.

Zhijie S7: Jiangsu Times Power Battery

On November 9th, the first model of Zhijie brand, which Chery cooperated with Huawei, was officially unveiled and pre-sold. Four versions of Zhijie S7 Pro, Max, Max+ and Max RS were launched, with the pre-sale price starting from 258,000 yuan. It is reported that Zhijie S7 will be officially listed on November 28th.

The length, width and height of Zhijie S7 are 4971mm/1963mm/1474mm respectively, and the wheelbase is 2950 mm. It is positioned as a medium and large-sized pure electric car. The new car is equipped with a new generation of DriveONE 800V silicon carbide power platform and Huawei Turing intelligent chassis. It adopts the combination of front AC asynchronous motor and rear permanent magnet synchronous motor. The total power of the four-wheel drive version is 365kW, the torque is 679N·m, the drag coefficient Cd is only 0.203, and the acceleration of 100 kilometers is only 3.3s s.

As for the battery, no more information is disclosed at present, but the official claims that the overcharged model can increase the cruising range by 200+km after charging for 5 minutes, which has basically reached the charging level of 4C. It is worth mentioning that the power battery pack carried by Zhijie S7 is a mix of lithium ternary battery and lithium iron phosphate battery, and its power battery supplier is Jiangsu Times, which is actually a wholly-owned subsidiary of Contemporary Amperex Technology Co., Limited.

Ideal MEGA: Contemporary Amperex Technology Co., Limited Kirin 5C battery

The ideal first pure electric MPV model-the ideal MEGA is quite hot, and the new car will also be booked at the Guangzhou Auto Show. It can be said that in addition to the appearance of a high-speed train locomotive, the concept of "5C" seems to be the beginning of the ideal MEGA. As the saying goes, "literature is no first, martial arts is no second". When it comes to 5C, people will think of the ideal MEGA first, and this label is even labeled. Of course, the ideal MEGA is not only popular in off the charts, but also has many mysteries. What we can know is that it is expected to be equipped with Contemporary Amperex Technology Co., Limited Kirin 5C battery for the first time, with a peak 5C charging rate, a peak charging current of 700A+ and a peak charging power of 520kW+. The official claim is that it has "brought the fastest charging speed of electric vehicles in the world-charging for 500 kilometers in 12 minutes".

Wubo HT: Haobo 5C Flash Rechargeable Battery

Haobo HT is the third model of Haobo brand. It is positioned as a medium and large pure electric SUV, and it was officially launched on November 15th, with a price of 213,900-329,900 yuan. The new car is built on the pure electric platform of AET3.0 and the electronic and electrical architecture of Spirit. The length, width and height of Haobo HT are 4935x1920x1700mm and the wheelbase is 2935mm, which really gives everyone a big surprise.

In addition, another killer configuration of Haobo HT is that it is equipped with an overcharged battery of up to 5C, which is officially called Haobo 5C flash charging technology. This is a set of closed-loop technology from recharging to battery. It is officially claimed that it can charge for 8 minutes and last for 400+ kilometers, and it will land earlier than the ideal MEGA.

Write at the end:

At the presentation conference of Zhijie S7, Yu Chengdong described the charging of Zhijie S7 as follows: charging for 5 minutes can last for 200+km, and charging for 15 minutes can last for 400+km. Take a closer look, that is to say, the approximate 4C charging power that Zhijie S7 can actually achieve may be 5 minutes in an ideal situation, and the charging power for the next 10 minutes will become 2C; For another example, the charging rate advertised by the ideal MEGA at first was not 5C, but 4C, but after it was changed to 5C, the heat of the ideal MEGA reached the second peak after its appearance was announced.

Higher fast charge rate is naturally the focus of current technical research, but from the consumer’s perspective, the actual experience of recharging is equally important. Only by the long-term word-of-mouth accumulation of users can we know more real feedback. I hope that the fast charging technology of "charging for 10 minutes and cruising for 400 kilometers" can be popularized on a large scale and really change people’s travel life.