Pilot Free Trade Zone: Braving the Tide in the Era of Reform and Opening-up (10th Anniversary Tour of Pilot Free Trade Zone)

  If you open the column,

  Building a free trade pilot zone is an important strategic measure for the CPC Central Committee with the Supreme Leader as the core to promote reform and opening up in the new era. This year marks the tenth anniversary of the construction of China’s Pilot Free Trade Zone. In the past ten years, their respective pilot free trade zones have implemented the decision-making arrangements of the CPC Central Committee, emancipated their minds, kept upright and innovated, launched a large number of basic and pioneering reform and opening-up measures, and formed many landmark and leading institutional innovations, effectively playing the role of a comprehensive experimental platform for reform and opening up.

  Starting from today, this newspaper will open a column entitled "10th Anniversary Tour of Pilot Free Trade Zone Construction", which will fully report the course of China’s pilot free trade zone construction in the past 10 years, and reflect the new breakthroughs and progress made in the transformation of government functions, the strategy of serving the country, the liberalization and facilitation of investment and trade, and the financial openness and innovation to serve the real economy.

  Recently, the General Secretary of the Supreme Leader made important instructions on further promoting the construction of the Pilot Free Trade Zone, stressing that in the new journey, on the basis of comprehensively summing up the ten-year construction experience, we should thoroughly implement the upgrading strategy of the Pilot Free Trade Zone, be brave in pioneering and tackling difficulties, explore in a wider field and at a deeper level, and strive to build a higher-level pilot free trade zone.

  In September 2013, China (Shanghai) Pilot Free Trade Zone was established. In the past ten years, the construction of China’s Pilot Free Trade Zone has been advancing all the way, and 21 pilot free trade zones have been set up in six batches, basically forming a new pattern of reform and opening up covering the east, west, north and south, and coordinating the coastal inland areas. In the new era and new journey, the respective trade pilot zones continue to change their concepts, bravely stand at the forefront of the times, comprehensively deepen reform and expand opening up, promote institutional innovation, and promote high-quality development.

    There has been a new breakthrough in institutional innovation

  Today, the products of South China University of Technology Industry Co., Ltd. have covered many overseas markets such as Asia, Europe, North America, South America and Oceania, thanks to various reform measures in Hubei Pilot Free Trade Zone.

  For example, Zhang Xi, manager of the international business department of South China University of Technology, said: "Under the new mode of consolidated taxation, enterprises can first remove the goods and then pay taxes centrally within the prescribed tax payment period, effectively reducing the financial pressure on enterprises and reducing customs clearance costs." More than that, from "paperless" to "free filling", to "one-stop online" and finally to "one-day", the export tax rebate process has been continuously optimized and convenient. In 2022, the total export tax rebate of South China University of Technology reached 123 million yuan, a year-on-year increase of 22%.

  Since the establishment of the Pilot Free Trade Zone, it has shouldered the heavy responsibility of institutional innovation and reform breakthrough. In the past ten years, the respective pilot free trade zones have taken institutional innovation as the core, replicability and popularization as the basic requirements, and risk prevention and control as the bottom line, and made every effort to promote reform and opening-up innovation in related fields, exploring new ways and accumulating new experiences for comprehensively deepening reform and opening up.

  Deepen the reform of the commercial system and stimulate the vitality of enterprises. Nansha District of Guangdong Pilot Free Trade Zone has realized "no appointment", "zero meeting", "all-weather", "paperless" and "intelligent" through the new mode of intelligent electronic registration. Through the implementation of standardized and intelligent declaration, the pass rate of self-declaration of enterprise name and the first application rate of electronic registration in the whole process all exceeded 90%, and the daily average business handling capacity of registrants increased by more than 30%. Applicants can print their own business licenses in 10 minutes at the earliest.

  Accelerate the reform of trade facilitation and improve the timeliness of customs clearance. In the West Coast Comprehensive Bonded Zone of Qingdao Area in Shandong Pilot Free Trade Zone, 16 containers and 314 tons of imported cotton passed through the intelligent weighing platform, and the rapid weighing and certification were completed within half an hour. Qingdao Huangdao Port is the largest cotton import port in China, accounting for about 60% of the country’s imports. In order to improve the level of imported cotton trade facilitation, in August 2020, Huangdao Customs launched the "integrated inspection" supervision mode of imported cotton in Qingdao Free Trade Zone, integrating customs port quarantine, destination inspection, weight identification, sampling and inspection, and improving the convenience of imported cotton customs clearance.

  On August 18th, China Ship Fuel Co., Ltd. completed the approval of a paperless business of direct supply of bonded fuel oil across customs areas. This batch of bonded fuel is delivered from Zhoushan oil depot, transported to Meishan Port Area of Zhoushan Port, Ningbo, and added to international navigation ships. Hangzhou Customs focused on the open development of the whole oil and gas industry chain, continued to deepen the regulatory reform, and helped Zhoushan area of Zhejiang Pilot Free Trade Zone to build the largest large-scale petrochemical base, energy security base and oil and gas trading port in China.

  Explore innovation in the financial sector and serve the development of the real economy. Since 2013, the State Administration of Foreign Exchange has tried 24 innovative measures for foreign exchange management in six batches of free trade trials, and copied and promoted nearly 20 measures nationwide in accordance with the principle of "mature one and copy one". In 2022, the cross-border revenue and expenditure of the Pilot Free Trade Zone increased by 14.7% year-on-year, 8.7 percentage points higher than that of the whole country.

    Promote opening up and make new progress.

  On the afternoon of September 1st, a remanufactured engine imported by Volvo Construction Equipment (China) Co., Ltd. for articulated off-highway dump trucks was declared at Shanghai Pudong Customs and delivered directly to the enterprise warehouse. "This engine is no less than a new product in terms of quality characteristics and safety and environmental protection performance. The smooth customs clearance of the first order of goods has reassured us to carry out the import business of overseas remanufactured products in the future. " Chen Chaoping, vice president of Volvo construction equipment service and spare parts, said.

  At the beginning of the establishment of the Shanghai Pilot Free Trade Zone, it set its sights on docking international high-standard economic and trade rules, took the lead in implementing the national treatment plus negative list management model before foreign investment access, and promoted the historical transformation of the investment management system. The development of Volvo in China is closely related to a series of policies of Shanghai Pilot Free Trade Zone to promote high-level opening to the outside world. Four years ago, the company completed the "first order" offshore trade in the Shanghai Pilot Free Trade Zone, and then the company moved its Asian headquarters to Shanghai. Now Volvo has become the first crab-eating enterprise in the "Pilot Import of Remanufactured Products in Key Industries" in China.

  Openness is a gene engraved in the bones of the Pilot Free Trade Zone. In the past ten years, the Pilot Free Trade Zone has been guided by a high level of openness, focused on exploring an institutional system that is in line with international economic and trade rules, systematically promoted reforms that conform to market rules, and achieved a series of breakthrough and leading innovations.

  Since the Pilot Free Trade Zone launched the first negative list of foreign investment access in China, after seven reductions, the number of negative list items has been reduced from the initial 190 to 27, and the number of manufacturing items has been zero. In 2021, the first negative list of cross-border service trade was launched in Hainan to promote the better connection between China’s service trade management and international high-standard economic and trade rules. At present, the list has been well implemented in Hainan, which has become an important reform in the opening up of China’s service industry and laid a solid foundation for its implementation in a wider scope.

  Differentiated exploration, opening up along the border has a new atmosphere. At Pingxiang Friendship Pass Port in Chongzuo Area of Guangxi Pilot Free Trade Zone, trucks loaded with fruits imported from ASEAN cleared customs in an orderly manner. Youyiguan Port is one of the most convenient land ports from China to Vietnam and other ASEAN countries. In order to ensure "zero delay" in fruit clearance in peak season, Youyiguan Port re-optimizes the traffic routes of inbound and outbound vehicles, and takes the lead in implementing "multi-card integration" of customs and border inspection departments at border ports across the country to share a bayonet, greatly shortening the traffic time of vehicles. In the first half of this year, ASEAN fruits imported through Youyiguan Port reached 381,000 tons, with a value of 11.39 billion yuan, up by 130.1% and 520.6% respectively.

  "From promoting the upgrading of port energy level to promoting the construction of major open platforms, from promoting the development of industries with distinctive advantages to optimizing the port business environment, Guangxi will further give play to the policy advantages of the Pilot Free Trade Zone and promote the realization of high-level opening up." Bai Lan, full-time deputy director of the China (Guangxi) Pilot Free Trade Zone Office, said.

  In 2022, 21 pilot free trade zones accounted for 18.1% of foreign investment and 17.9% of import and export trade in China, with less than four thousandths of land area, and further increased to 18.4% and 18.6% in the first half of this year.

    High-quality development has achieved new results

  On September 21st, the opening ceremony of Wazhou Wind Power Spindle Bearing Company was held in Dalian, Liaoning Pilot Free Trade Zone. The total investment of the project is 1 billion yuan, with a total construction area of 32,000 square meters. The new factory will intellectualize and digitize the traditional production process and management mode, and mainly build a series of fist products with high-end brand inheritance of Wazhou. It is estimated that the annual output of bearings will be 36,000 sets, with an annual output value exceeding 1.5 billion yuan.

  Dalian Free Trade Zone gives full play to the advantages of equipment manufacturing technology and talents in the old industrial base in Northeast China and the advantages of pioneering and testing in the Pilot Free Trade Zone, and strives to cultivate and expand advanced equipment manufacturing industrial clusters. Now, it has formed a number of characteristic subdivisions such as CNC machine tools, refrigeration equipment, special containers, auxiliary power devices, nuclear power equipment and special motors. There are 154 advanced equipment manufacturing enterprises above designated size in the region, with an output value of 28.1 billion yuan in 2022.

  In the past ten years, the respective pilot trade zones have actively promoted the development of new industries, new formats and new models, and built a number of industrial clusters with strong competitiveness, injecting new kinetic energy into high-quality development.

  Create a public service platform and promote the agglomeration of new industrial elements. Nanjing Area of Jiangsu Pilot Free Trade Zone has built the first integrated circuit public service platform covering all production factors in China, highlighting demand orientation and transforming and upgrading the service industry. "The platform jointly provides all-factor services such as public technology, talent training and core machine linkage for integrated circuit enterprises in the Yangtze River Delta." Lin Qikun, member of the Party Working Committee of Nanjing Jiangbei New District and deputy director of the Management Committee, said that up to now, the platform has provided more than 13,000 public technical services, with a service amount of over 500 million yuan, supporting the research and development innovation of nearly 600 kinds of chip products.

  In response to market demand, Nanjing Customs cooperated with the commercial department to formulate an implementation plan for enterprises in the Pilot Free Trade Zone to carry out bonded maintenance business according to the maintenance catalogue of the comprehensive bonded zone, and promoted the bonded maintenance policy to cover the Pilot Free Trade Zone.

  Seize the new wave of digitalization and promote the vigorous development of new formats. In March of this year, Zhejiang Pilot Free Trade Zone released the Action Plan for Promoting the Development of China (Zhejiang) Pilot Free Trade Zone (2023— 2027), clearly pointed out that it will build a leading digital economy industrial system, take the lead in integrating high-standard digital trade rules, and promote the establishment of a data-based system. Strive to increase the import and export volume of cross-border e-commerce to 420 billion yuan by 2027, the trade volume of digital services to 250 billion yuan, and the growth rate of added value of core manufacturing industries in the digital economy to maintain above 8%.

  Shanghai Pilot Free Trade Zone has established a modern industrial system with six major industries as the core: China Core, Innovative Medicine, Intelligent Manufacturing, Blue Sky Dream, Future Car and Data Port. Tianjin Pilot Free Trade Zone has gathered strength to develop the financial leasing industry and become the second largest gathering place for aircraft leasing in the world. There are tens of thousands of oil and gas enterprises in Zhejiang Pilot Free Trade Zone, and the scale of bonded fuel oil filling ranks fifth in the world. Hubei Pilot Free Trade Zone has gathered more than 16,000 optoelectronic information enterprises, making it the largest technology R&D and production base in the field of optical communication in China. There are more than 4,000 biomedical enterprises in Jiangsu Pilot Free Trade Zone, with an annual output value of over 400 billion yuan.

  Standing at a new starting point, China Pilot Free Trade Zone is taking high-level opening as the guide, taking institutional innovation as the core, coordinating development and safety, connecting international economic and trade rules with high standards, deepening institutional opening, strengthening overall planning and system integration of reform, promoting the innovative development of the whole industrial chain, giving full play to the demonstration role of Pilot Free Trade Zone, and striving to make greater contributions to promoting Chinese modernization.

Jin Dongyan: Thoughts on Fighting COVID-19 Brought by the Study of the First Six Human Coronavirus and HIV

Editor’s Note: novel coronavirus is the seventh discovered human coronavirus. In the past three months, the whole world has witnessed it from discovery to pandemic. At present, its intermediate host, specific drugs, vaccines and other key issues remain unresolved. Jin Dongyan, a professor of precision medicine at the Huo Guangwen Couple Fund of the University of Hong Kong, believes that by reviewing the past lives of the previous human coronaviruses and learning from the exploration process of HIV virus, which is the most clearly studied in human history, we may find some ideas.

On April 9th, Jin Dongyan shared the past lives of human coronavirus in the fifth scientific lecture "Understanding the Future: Virus and Human Health-Special Science Popularization" sponsored by the Future Forum of Scientific Public Welfare Organization.

Jin Dongyan concluded that the four coronaviruses (229E, OC43, NL63 and HKU1) have very good adaptability in humans, and they have spread in humans without an intermediate host of animals. They can cause the common cold and exist in people all the year round. However, SARS and MERS need an intermediate host of animals. They are not fully adapted, with strong pathogenicity and high mortality. However, human-to-human transmission cannot be sustained and can be effectively controlled by isolation. Covid-19 is somewhere in between. It is similar to SARS, but it is more contagious and less pathogenic, but its pathogenicity is still higher than other human coronaviruses.

In terms of drugs, Jin Dongyan opposes using steroids to treat SARS or COVID-19. He said that the human body relies on its own immunity to defeat the virus, but the immune response also causes symptoms, including cytokine storms and lung inflammation. As we all know, the anti-inflammatory reaction of steroid hormones is immediate, but if the immunity is suppressed, the virus cannot be controlled, but it will increase greatly.

The full text of the speech was arranged by Guo Lijie, a doctoral student of Institute of Biophysics, Chinese Academy of Sciences. The Paper was authorized to sort out and publish it for the second time.

Jin Dongyan: past lives of human coronavirus

I’m Jin Dongyan from the University of Hong Kong. I’ve been working on the interaction between virus and immunity, virus and cells for many years. The topic to share with you today is past lives of human coronavirus. COVID-19 is the seventh human coronavirus. Let’s talk about the past lives of these human coronaviruses, that is, where did they come from? What will it be like in the future? Make a review and put forward some prospects.

We should first talk about the fact that human coronaviruses are all from animals, followed by the genome structure of coronaviruses and the characteristics of their replication, as well as the characteristics of this COVID-19 disease, relevant specific diagnosis and treatment, and the development of new antiviral drugs and vaccines.

Storage and Intermediate Hosts of Seven Human Coronavirus Species

I will focus on the storage host and intermediate host of human coronavirus. In the natural storage host, there are a large number of different kinds of viruses, which generally do not cause disease or only cause very mild symptoms. Intermediate hosts often refer to hosts from storage hosts to people or to new hosts. Intermediate hosts are not necessarily virus storage hosts, but they may become storage hosts after a period of adaptation. This concept seems to be more complicated. For example, the storage host of HIV is chimpanzee or mangabey, and the storage host of influenza virus is mainly waterfowl. We will explain the storage host and intermediate host of human coronavirus in turn.

HIV is the most clearly studied virus in the world. Many scholars who study other viruses can learn some methods or ideas from HIV research, so we can focus on reviewing what we have learned from HIV research. Incidentally, I will also focus on the drug research in Covid-19, the existing drugs and the future drug development direction.

This time, from December 31, 2019, when the discovery of Covid-19 was announced to today, we have truly witnessed the occurrence of the virus from discovery to global pandemic for more than three months, and the development of the epidemic situation has been recorded in this way for the first time in history. In this process, scientists in China made many contributions, such as we announced the discovery of a new virus on December 30th, determined the nucleic acid sequence on January 12th, and then quickly shared the data with the whole world. Of course, there are also shortcomings. Before January 20th, we didn’t have a good grasp of the epidemic situation of the virus, which is worth summarizing in the future. Generally speaking, we have done well, but we have not done enough. On March 11th, the World Health Organization declared COVID-19 a global pandemic, and on April 8th, Wuhan was unsealed.At present, the timeline is like this.

There are several names here, SARS-CoV-2, which is the name given to the new virus by the International Viral Nomenclature Committee. Of course, some scientists have different opinions on this. For the sake of standardization, we still call it SARS-CoV-2, and the other name is 2019 COVID-19. The World Health Organization calls it 2019 coronavirus disease, that is, COVID-19, SARS-CoV-2 and Covid-19.

Structure of coronavirus

Take SARS coronavirus as an example, and SARS-CoV-2 is very similar to it. In the structure, yellow corresponds to fibrillar protein, green is nucleocapsid protein, and gray is membrane protein. These are structural proteins. Most of its genome at the 5′ end is open reading frame 1(ORF)1ab, which is a replicase, and then the relative positions of some protein coding regions in the genome. In addition to the above mentioned, this virus also contains some small proteins, such as 0RF6, ORF7a, ORF8, ORF10, etc. These proteins are lineage-specific, and are mainly helper proteins responsible for the interaction with the host. This coronavirus is a single strand RNA virus with about 30,000 nucleotides. Its replicase will be hydrolyzed by host protease and become a variety of unstructured proteins.

This picture summarizesAnimal origin of human coronavirus. There are seven kinds of human coronaviruses, and the earliest two are 229E and OC43. Later, SARS appeared in 2003 and MERS appeared after 2012. In the past, coronavirus was not paid much attention to, and there was little research for a long time. The main reason is that people think that coronavirus can only cause the common cold, which is even weaker than the flu. This is the case with 229E, and so is OC43. However, the emergence of SARS in 2003 completely subverted this concept, and the mortality rate of SARS reached nearly 10%. Later, MERS occurred, which is a serious respiratory virus, that is, Middle East respiratory syndrome virus, which was found in the Middle East. MERS is more pathogenic than SARS, and its fatality rate reaches 35% to 40%, which has changed human understanding of coronavirus.

After the outbreak of SARS in 2003, two teams of Hong Kong scientists and Dutch scientists discovered two new human coronaviruses, one named HKU1 and the other named NL63. These two viruses, like the first two viruses, only cause the common cold. Therefore, these four viruses (HKU1, NL63, 229E, OC43) do not need other animal hosts, and appear in human groups all the year round. We call them community-acquired human coronavirus.

The seventh virus is Covid-19 SARS-CoV-2 discovered this time. I think Covid-19 is a new virus between these two types of viruses, and it has both characteristics, so which direction it will go in the future remains to be studied and observed. These human viruses have been studied for many years, especially by Professor Yuan Guoyong from the University of Hong Kong, Professor Jiverly Voong from the National University of Singapore and Duke University, and Professor Shi Zhengli from Wuhan Institute of Virology. It is clear that these coronaviruses are all from bats. Five of them (NL63, 229E, SARS, MERS and Covid-19) are definitely from bats, so bats are the storage hosts of these viruses.

Some of them we also know about their intermediate hosts, and the most clear one is the dromedary, the intermediate host of MERS. The intermediate host of 229E may be alpaca, camel, or directly transmitted from bat to human. Professor Guan Yi found that the intermediate host of SARS-CoV was civet cats. The intermediate host of SARS-CoV-2 may be pangolin, but it is inconclusive, and we will explain it in detail later. OC43 and HKU1 are generally considered to come from rodents, and an important intermediate host of OC43 is cattle.

Let’s go back to the dromedary, the intermediate host of MERS-CoV. MERS-CoV originated from bats at first, but the virus has adapted in camels, so camels have changed from an intermediate host to a storage host. The virus is less pathogenic after infecting camels and will not kill them. There is an important message to remind everyone that these four kinds of human coronaviruses that only cause the common cold now, what were they like before? There are historical clues that OC43 spread from cattle to humans around 1890, and the OC43 virus in cattle is very similar to that in humans. There was also a global epidemic of respiratory virus around 1890, and the symptoms were a bit like SARS-CoV-2, which was more serious. Therefore, there is a view that these four viruses that only cause the common cold, when they first spread from animals to people, also caused a global pandemic with more serious symptoms than now, which is also some inspiration from reviewing the history of human coronavirus.

The evidence that human coronavirus comes from bats was first discovered by Chinese scientists. After the outbreak of SARS in 2003, many scientists still insisted on tracking and doing in-depth research, instead of staying on the surface, which is very worthy of our admiration.The first group is Professor Yuan Guoyong, Professor Hu Zhaoyi and Professor Liu Jiapei of the University of Hong Kong, and the other group is Professor Jiverly Voong who was in Australia at that time. Professor Shi Zhengli was also in his laboratory at that time. Later, Professor Shi Zhengli insisted on studying bat virus and was one of the best scientists in this field in China. The groundbreaking contributions of their two teams showed that bats were an evolutionary storage host for a variety of human coronaviruses. Of course, in addition to coronavirus, bats are also the storage hosts of many other human viruses. Bat has some characteristics. It is the only flying mammal. It has a particularly strong anti-virus ability and produces a lot of interferon after infection.

The dromedary camel is the intermediate host of MERS coronavirus. MERS virus is found in dromedary camels in the Middle East all the year round, and it has changed from the intermediate host to the storage host. SARS-CoV is found in civets only in certain wild animal markets, and civets also have symptoms after being infected. SARS virus can not be found in farm-raised or natural civets. Therefore, it is concluded that civet cats may be a transient intermediate host of SARS virus, and its important role is to expand the scale of human infection by transmitting the virus to people. MERS-CoV is transmitted from camel to human repeatedly every time, which has limited spread among people and has no foothold in people. The same is true of SARS. After we took decisive measures to control civet cats, it never happened again that civet cats were transmitted to people. MERS is not like this. People in the Middle East are so closely related to camels that they can’t kill all the camels. Therefore, from 2012 to now, it is still spreading to people. This is the case with MERS and SARS. These two viruses will not continue to spread in people, and will cease to exist after several generations.

What is the situation of SARS-CoV-2?Professor Shi Zhengli found a virus with 96% homology with SARS-CoV-2 in Chinese bat shortly after discovering this virus. This situation is very similar to that of SARS-CoV. Professor Yuan Guoyong and Professor Jiverly Voong also found a virus with 95% homology with SARS-CoV in bats. For the intermediate host, the virus which is almost 99.9% similar to human SARS virus is found in civet cats, but in pangolins, especially those smuggled from Malaysia or Southeast Asia to China, the β-coronavirus carried by them has only about 90% homology with SARS-CoV-2, which is lower than that of bat virus. But it doesn’t mean that it has no contribution at all. Its receptor binding domain is similar to that of human SARS-CoV-2. So what is the relationship between the two viruses found in bats and pangolins and SARS-CoV-2 found in people needs more research to answer.

Many of us who study viruses want to find some answers or find inspiration and ideas in HIV. Let me quickly introduce how HIV comes from animals. After years of tracking by many virologists, they found that there are two kinds of HIV in people: HIV-1 and HIV-2. Among them, HIV-1 comes from chimpanzees and HIV-2 comes from mangabey. However, after further tracking, it is found that there are still very complicated relationships. HIV-1 was transmitted from chimpanzees to people, but the infection actually happened many times, among which M group had the largest number of infected people, followed by O group, and N was only a few people. HIV-2 also occurred many times, but only once or twice survived in the crowd. We compared their genome differences, evolutionary relationships, and whether their geographical locations overlap, and finally found out the reason. People eating animals or taking them as pets caused the spread of the virus from animals to people.

We compared the whole genome of the host and virus, and found that COVID-19 virus is the closest to Bat RaTG13, but far from Malaysian pangolin. However, if we only compare their receptor binding domains, we will find that Covid-19 is more similar to pangolin than Jutous Bat. The bat genome is more similar to COVID-19, but the receptor binding domain is only 75% homologous, while the pangolin genome is only 90% homologous, but the receptor binding domain reaches 97%. This work is also an important contribution made by Professor Guan Yi and Dr. Lin Zanyu.

Let’s compare the fibrillary proteins. This is SARS-CoV-2, and these are bat and pangolin viruses. We found that it inserted several sequences. One of them has inserted three arginine and an O- glycosylation site. The source of these sequences remains to be studied. Earlier, some Indian scientists said that this insertion was related to HIV, but in fact, they were not related. But how it came into being in the evolution of nature remains to be studied. If the animal coronavirus with this insertion site is found in the next step, it can provide another missing puzzle for the traceability of the virus.

Looking back, we said that the animal traceability of SARS-CoV-2 is still in an unresolved state. If we really want to solve this problem, we must find the virus with more than 99% homology with the whole genome of Covid-19 in animals. If it comes from bats at the earliest, finding a virus with more than 99% homology with COVID-19 in bats can provide evidence. If it comes directly from pangolin, it is necessary to find a virus with a very similar genome in pangolin. Because what is found now is pangolin in Malaysia, it is also possible to find something closer in pangolins in other areas, and it is still unclear.

Comparison of seven human coronaviruses

This is a comparison between seven human coronaviruses, including HKU1, SARS and MERS. At the beginning, we continued to trace the source and found HKU9 and HKU4 in bats. It was predicted that these bat viruses might be found in human groups. Sure enough, a few years later, the MERS coronavirus most similar to HKU9 was found in the Middle East, which was also the result of Professor Hu Zhaoyi and Professor Liu Jiapei’s long-term persistence in bat virus research, which provided important clues for the later research, diagnosis and traceability of MERS coronavirus. Therefore, it is still meaningful for us to do the work of animal traceability.

This table compares the characteristics of these seven different coronaviruses. The incubation period is mostly within one week, MERS and SARS are a little longer, and most of SARS-CoV-2 is still relatively short, which is somewhere in between. Human coronavirus is seasonal, but whether SARS-CoV-2 is seasonal is unknown. But generally speaking, its mortality rate is relatively low. Some time ago, the mortality rate in the world was only 3.5%, and now it may be higher.

To sum up the human coronavirus 229E, OC43, NL63 and HKU1, they have very good adaptation in human beings, and they have spread in human beings without animal intermediate hosts. They can cause the common cold, can be obtained in the community and exist in people all the year round. It can cause infection and is very contagious. However, SARS and MERS need an intermediate host of animals. They are not fully adapted, with strong pathogenicity and high mortality. However, human-to-human transmission cannot be sustained and can be effectively controlled by isolation. SARS-CoV-2 is in between. It is similar to SARS-CoV, but it is more infectious and less pathogenic, but its pathogenicity is still higher than other human coronaviruses.

asymptomatic carrier

When it comes to COVID-19, we should especially point out Professor Yuan Guoyong and Dr. Chen Fuhe, who have conducted in-depth and meticulous genealogy research since January 10th, which requires very good insight, leadership skills and the spirit of seeking truth and being pragmatic. You may not have noticed the significance of this work. They finished it on January 17th. What did they find? First, the virus can be transmitted from person to person with conclusive evidence, and its transmission rate reaches 83% within the family. Of the seven people in Shenzhen, six were infected, and then back to their families, including members in Wuhan, a total of 83% were infected, which definitely showed that the virus was highly contagious. At the same time, they also noticed that the patient had diarrhea symptoms and found an asymptomatic 10-year-old boy, but his nucleic acid test was positive. We now have more than 80,000 confirmed cases, but they all figured out the epidemic characteristics and important characteristics of the virus as early as January. The earliest case was January 10, and there was an asymptomatic infected person in it.

Their work is very worthy of praise, which has made a key contribution to reversing the passive situation of epidemic prevention and control, and provided a scientific basis for the country to set right prevention and control strategies. It can be seen that both basic and clinical work can actually play an important role in epidemic prevention and control. This work also reflects the value of the University of Hong Kong and the important position and role of Shenzhen Hospital of the University of Hong Kong.

Strengthening the monitoring and research of asymptomatic carriers, I have been calling for it since it was discovered on January 17, and many other scientists are calling for it, and now we finally pay attention to it. We should pay attention to whether their viral load is high or low. What is the ratio of the two? What is the release of the virus? These are all very worth figuring out. In addition to asymptomatic, some patients are contagious in the incubation period, and some patients have very mild symptoms. The virus transmission of these people also needs attention.

Let’s talk briefly, what is the situation of these asymptomatic people? I think there are two situations, one is like a storage host, which is not pathogenic. Like influenza virus in waterfowl is disease-free, AIDS in chimpanzees and white-topped mangabey is also disease-free. There are also many asymptomatic carriers of human coronavirus. In one case, they may have a strong antiviral response and their virus replication is inhibited to some extent. In this case, their viral load is relatively low. The other situation is worse. In monkeys and chimpanzees, the replication of HIV is decoupled from the immune response. Although infected, the immune response is weak. In this case, their viral load is relatively high and dangerous. The proportion of these two situations is very worth figuring out.

When it comes to the mutation rate of virus, we compare HIV and SARS-CoV, which are relatively close. There is little difference between different strains of SARS-CoV-2. There are 200 to 300 differences among 30,000 bases, but SARS-CoV-2 has only a single digit. Therefore, the mutation rate of this virus is relatively low, and now it has basically no mutation. The strains in Italy, Hong Kong and Wuhan are very similar, and there is not much change. This situation may also indicate that it has a strong adaptability to the human body.

Let’s go back to the storage host. The variation of HIV in the storage host is also relatively low. Some people speculate that the virus has been transmitted to people after some adaptation in the intermediate host, so the mutation rate in people is relatively low now. This situation is different from SARS-CoV, but it is similar to MERS-CoV. All coronaviruses have a correction enzyme, and exonuclease is responsible for the correction, so it can ensure that its mutation rate is low. If the correction enzyme is inhibited or knocked out, the mutation rate will be high, and the virus toxicity will be weakened or even unable to survive.

Virus detection

Let’s talk about the specific diagnosis of SARS. The specific diagnosis still depends on reverse transcription PCR, that is, polymerase chain reaction.

Test the nucleic acid of the virus. If antibodies are used for detection, colloidal gold can be used to detect IgG and IgM of antibodies, and ELISA can also be used to detect antigen antibodies. At present, the most important thing is to rely on nucleic acid detection. The detection of antigen and antibody has just begun, and the quality of antigen reagents has to be approved by the state. One of the problems is relapse. Some people find that nucleic acid tests are negative twice and then positive after a while. Why? I think the biggest possibility of this situation is that it is not accurate, that is to say, the virus has not been removed when the test is negative.

This is to explain the changes of nucleic acid antigen antibody. Let’s take HIV as an example. Its RNA is red peak, antigen is green peak and antibody is blue peak.

This is RT-PCR detection method, which is mainly detected by fluorescence quantitative PCR, and it is a magic weapon for us to make specific diagnosis now.

This is an antibody test using colloidal gold.

Of course, a simpler method is ELISA, which can test both antibodies and antigens. If you want to test antibodies, you must produce high-quality antigens. If you want to test antigens, you must have high-quality antibodies.

COVID-19 medicine

We talked about Covid-19’s treatment. One way is to use the old medicine in a new way, using interferon, ribavirin, RNA polymerase inhibitor, Remdesivir and convalescent serum. The FDA recently approved two drugs for COVID-19’s treatment, one is convalescent serum, and the other is chloroquine phosphate. We still allow the use of steroids in the diagnosis and treatment from the first edition to the seventh edition. I want to focus on my analysis and views on this issue.

Let’s look at the mechanism of action of these drugs first. Ribavirin inhibits the synthesis of mRNA cap, thus blocking the transcription of viral RNA, so it is broad-spectrum antiviral. Interferon has remarkable antiviral activity and immunomodulatory activity. Chloroquine phosphate has some effects on autophagy.

We found from the literature that Remdesivir is effective against common community-acquired coronavirus, SARS-CoV and MERS-CoV, and its action sites are mainly polymerase and exonuclease with correction function.

Moreover, in the treatment of COVID-19, we have noticed that steroid hormones are widely used in mainland cases, and some Chinese medicines also have steroid-like characteristics. It is known internationally that the use of steroid hormones will prolong the course of disease for other coronaviruses, and whether the prolongation of the course of disease has an impact on the prognosis of the disease deserves further study. Previously, SARS-CoV found that the virus had been released in the gastrointestinal tract for a short period of one month and the longest period was two or three months. Because of intestinal mucosal immunity, even if there are neutralizing antibodies in the blood, it can’t protect the intestine.

This picture is a virus on the one hand and an immunity on the other. The human body relies on its own immunity to defeat the virus, but the immune response also causes symptoms, including cytokine storm and lung inflammation. Most of our drugs are antiviral drugs. If the virus is eliminated, these symptoms will be alleviated. As we all know, the anti-inflammatory reaction of steroid hormones is immediate, but if the immunity is suppressed, the virus cannot be controlled, but it will increase greatly. Therefore, I have been very opposed to using steroids to treat SARS or COVID-19 since 2004.

Let’s talk about hormones. The effects of hormones on coronavirus have been well studied for a long time. The work published in PNAS in 1964 found that mice or cells could not be infected by mouse hepatitis virus, but could be infected immediately if given hormones. The paper published in Gut in 1969 has been studied in detail from the cellular level to the animal level. I want to remind you that they see that high-dose steroids have the strongest effect on promoting virus replication and enhancing pathological reaction, but even if only low-dose 0.05mg hydrocortisone or 0.1mg prednisolone is used every day, they can still see the stimulating effect on virus replication. The use of steroids can stimulate the virus to replicate 50 to 1000 times. As for SARS-CoV, the experience summarized in Hong Kong at that time was that steroid use would cause more deaths and make the disease more serious. Studies on MERS also clearly show that steroids can prolong the clearance of the virus.

We can learn a lot from HIV. According to the replication cycle of HIV, there are anti-fusion drugs to inhibit virus fusion, anti-receptor drugs to inhibit receptor binding, and then reverse transcriptase and protease inhibitors. Protease inhibitors can be used for HIV and COVID-19. Professor Jiang Shibo, our host, is a pioneer in this field. By understanding the interaction between proteins on the virus surface and cell receptors, we can inhibit the fusion of viruses and cells.

The drug developed by Professor Jiang mainly inhibits the interaction between the two spiral regions HR1 and HR2 in the fibrillar protein on the virus surface, and the antiviral effect can be achieved by inhibiting their interaction. The same principle can be applied to COVID-19. These are all directions worthy of our study. I believe you can hear Professor Jiang Shibo’s wonderful speech in the next round of reports.

We can learn from these therapeutic drugs from HIV, including drugs that inhibit the virus from entering cells, protease inhibitors, replicase inhibitors, helicase inhibitors, cell target drugs and anti-inflammatory drugs, which are worth studying and trying out. Anti-inflammatory drugs contain antibodies against interleukin-6 receptor, which can inhibit the effect of interleukin-6. At present, it has achieved good results in fighting the cytokine storm in COVID-19. Among the target drugs of cells, TMPRSS2 protease can cut the fibrillar protein of SARS-CoV or SARS-CoV-2 into S1 and S2, and inhibiting this enzyme does inhibit virus replication.

Covid-19 Vaccine

Let’s talk briefly about vaccines. There are many types of vaccines, including inactivated vaccines, dead vaccines, some delivered by carriers, and some subunit vaccines, protein vaccines, DNA vaccines and mRNA vaccines.

The prevention of poliovirus was originally carried out with inactivated vaccine or attenuated live vaccine. The development of vaccines has taken years. In the past, many virologists made one or two vaccines in their lifetime, and what they left behind was our wealth.

DNA vaccine can be delivered in different ways, which may be naked DNA, or it may be encapsulated in nanoparticles. DNA vaccine can directly act on antigen presenting cells, or indirectly deliver antigen to antigen presenting cells after intramuscular injection/subcutaneous injection, so as to deactivate B cells and T cells and activate antibody immunity and cellular immunity respectively. So the advantage of DNA vaccine is that it can activate both cellular immunity and humoral immunity.

The advantage of DNA vaccine is that it is easier to develop than protein vaccine, but the disadvantage is that its immunogenicity is particularly poor. Because DNA will be integrated, in order to solve this problem, an mRNA vaccine has been developed to produce mRNA from cDNA, or this mRNA can be made by in vitro transcription or even synthesis, and then the protein is directly expressed in the cytoplasm through mRNA, and the antigen of the protein is transmitted to the presenting cells to activate immunity. Of course, if we increase the delivery of mRNA, we can use the nanoparticles of this liposome to package the imaging virus to increase its stability and anti-RNase ability.

MRNA vaccine is the first vaccine approved for human safety test in the United States. Our country has approved an adenovirus vaccine. We use adenovirus vector to present COVID-19’s fibrillar protein, but we need to pay attention to whether adenovirus can trigger immune response. These methods can be used to develop COVID-19 vaccine, and the simplest one is of course inactivated vaccine. The virus is collected and killed by formalin or ultraviolet radiation to prepare inactivated vaccine, but the safety is hidden. In the past, some SARS vaccines have been tested in human clinical trials and have certain effects. But the safety and effectiveness are still worth studying. It is more challenging to prepare an attenuated live vaccine, which has the advantage of stimulating a comprehensive immune response. Or prepare subunit vaccine, and only express some virus subunits. Or a vaccine prepared by using a viral vector, such as the vaccine that uses adenovirus to express fibrin this time. At present, every vaccine is worth trying, and we will use which one can succeed. Even if the vaccine is not ideal, it can still be used with good immune effect.

These are the methods that have been practiced in the past, and the new vaccine involves recombinant DNA, second-generation sequencing or structural biology, which can make the vaccine better.

What I want to share with you is mainly the above.

Full-bed 6-person research guarantee rate is 100%!

All ashore, not one less!

Recently, six students from the same dormitory of the School of Mechanical Engineering, North University of China collectively participated in the postgraduate study. During the undergraduate study, 406 Dormitory was "brilliant"-the average credit score was as high as 4.14, and it won 19 scholarships and 50 honors above the university level … They helped and encouraged each other for four years, and finally six students were sent to Beijing Institute of Technology, Beijing University of Posts and Telecommunications, xidian university, Nanjing University of Aeronautics and Astronautics and north university of china respectively.

Learning is a common interest without "volume"

Teenagers’ dreams are not limited to their hearts, but also to their actions.

From the first day when six students moved to the dormitory, learning became everyone’s common interest.

The six seats in the middle of the first row of the class will always be the "exclusive seats" of the 406 dormitory. Helping each other to occupy seats is not only the first stop of the friendship between six people, but also the last class of the university.

After school, six people in the dormitory go to the library together, rain or shine. In the final review stage, everyone will be the "review teacher" of a course, sorting out the key points of the exam and explaining the difficulties of the course for everyone.

"There are always classmates who say that our dormitory is too’ rolled’, but it is not. Learning is really the common interest of all six of us." Gao Lei, who was sent to xidian university, said.

Cooperation is the key to all employees’ research.

Science and technology competition is an important part of the road to research. Although six people in the 406 dormitory belong to different teams, the dormitory has become everyone’s "support group".

Wang Xuetong, who was sent to Beijing University of Posts and Telecommunications, is good at three-dimensional modeling, and other related problems encountered in project construction can be solved when they are brought back to the dormitory. At the same time, dormitory members often share competition information in the group, and everyone needs what they want, which has become an important weight for the success of the research in the future.

No victory is easy to come by. Although six students in the dormitory rank among the top ten in their majors, they are still somewhat "confused" when faced with the choice of medical insurance, master’s degree and master’s degree in engineering.

At critical moments, six people often analyze everyone’s "situation" in the form of meetings and collect information from all sides. Especially in the school selection stage of Baoyan Foreign School, when only Wang Xuetong didn’t receive the admission notice, all the dormitory members went into battle and actively recommended it to teachers in different universities, and finally got the admission notice from Beijing University of Posts and Telecommunications just before the system was closed.

In the end, two members of the dormitory, Wang Wentao and Chen Haowen, landed in north university of china, and four members, Gao Lei, Wang Xuetong, Wang Yukun and Ma Xin, were sent to xidian university, Beijing University of Posts and Telecommunications, Beijing Institute of Technology and Nanjing University of Aeronautics and Astronautics respectively.

Cherish, friendship will last forever.

Baoyan is not a process of fighting alone, but a process of mutual achievement. Strong friendship has become a "catalyst" on their road to baoyan.

After four years of living together, although everyone is full of expectations for the future, they are still reluctant.

"It’s rare to meet such a roommate!" Ma Xin, who was sent to Nanjing University of Aeronautics and Astronautics, said with emotion, "We have the same attitude towards learning and entertainment-we are fully engaged in learning and enjoy playing!"

There is also an interesting agreement that has been adhered to in the 406 dormitory, that is, every time someone with a higher scholarship will invite someone with a lower scholarship to dinner.

Soon, everyone will go to different colleges and universities for further study, and they have made an agreement, hoping to have a meal at everyone’s school, so as to make this hard-won friendship continue.

Gathering is a fire, scattering is all over the sky.

The days of struggle together are the most shining memories of these six North American students in their youth. With the school motto of "knowing what to do", they will help each other in the same boat and cut the waves, and they will certainly take each other’s blessings to a brighter future. (Image courtesy of north university of china)

Between "family" and "self", the married man has perfected the art of "carrying water"

  CCTV News:The Survey of Good Life in China pays special attention to the consumption characteristics of married men. Where do they spend more? What are the differences between the consumption characteristics of married men in different regions? Let’s take a look.

  According to the data of China Good Life Survey, married men have a strong sense of family responsibility. Cars, housing and insurance are their favorite consumption, and their consumption in these three aspects is obviously higher than that of men in other States. At the same time, however, they have the greatest pressure to shoulder family responsibilities, and they spend the least on entertainment consumption such as tourism, culture and entertainment. Another interesting discovery is that responsible married men are more eager to get promoted in education and training. Being a good husband, a good father and a good son, married men seem to be working hard on this road.

  In the comparison of married men’s consumption expenditure in seven regions, the survey found that married men in South China love to buy houses most, men in Southwest China love to buy cars most, people in Northwest China love fitness more, and people in Northeast China prefer digital products such as computers and mobile phones. Married men in North China have a great demand for self-improvement and pay more attention to health preservation.

  In the comparison of different types of cities, married men in first-tier cities spend far more on housing than married men in second-and third-tier cities, while married men in second-and third-tier cities spend significantly more on health care, cars and tourism than those in first-tier cities. In contrast, married men in first-tier cities are under greater pressure and have no life to settle down.

  No matter where they are, married men in the first, second and third tier cities are surprisingly consistent in spending on education and training. According to the data of the past ten years, married men in different types of cities have reached a high degree of unity in education and training expenditure for the first time.

  Married men generally pursue high-profile education and training consumption. Where do they spend all their money? A more in-depth survey on the Internet found that more than 70% of married men who have a high willingness to spend on education and training actually spend money on their children’s education. What a pity for inherit the wind!

  What do married men choose to do in their leisure time in a day? A large survey found that between "family" and "self", the art of "carrying water" by married men has been perfected. Nearly half of the married men are willing to undertake the trivial housework during this time, 38.96% of them just want to "quietly" brush their mobile phones, 36.98% choose to watch the world through TV, and 31.12% are willing to experience life in a sweat.

After the Spring Festival, these 7 good news will make you full of energy!

  CCTV News:The balance of the Spring Festival holiday has gone to zero. Do you still get used to going to work after the holiday? What important policies did the country release this week? What aspects of our lives will change in the future? Let’s review together

  (1) social security card will basically realize the national card.

  Statistics show that by the end of 2016, the number of social security card holders in China reached 972 million. In many places, people can meet various needs such as medical registration and financial payment with a social security card. In 2017, the social security card will basically realize the national card.

six

  According to the Opinions of the Ministry of Human Resources and Social Security on Accelerating the Application of Social Security Cards, the application of social security cards in the future is very extensive, and the application catalogue can be divided into nine categories and 102 items, involving all aspects of daily life and work. By the end of 2017, the social security card can also directly handle individual human resources and social security affairs across regions and businesses, and basically realize the national social security card.

seven

  ② The development plan of Beibu Gulf urban agglomeration was approved.

  The State Council recently approved the development plan of Beibu Gulf Urban Agglomeration, requiring the governments of Guangdong, Guangxi and Hainan provinces to strengthen their organization and leadership, improve the cooperation mechanism, clarify the division of responsibilities, and ensure that all objectives and tasks are implemented. Beibu Gulf will become an important economic sector in China, and it is also the only economic sector between China and ASEAN with both land border and sea passage. The approval of the plan will greatly promote the activity and economic development of this plate.

eight

  ③ The highest detection boxing punishes "village tyrants" and attacks "protective umbrellas"

  Recently, the Supreme People’s Procuratorate issued the Opinions on Giving Full Play to the Procuratorial Function to Punish the Crimes of Village Bullies and Clan Evil Forces and Actively Maintaining Rural Harmony and Stability, demanding that procuratorial organs at all levels resolutely punish the criminal crimes of Village Bullies and Clan Evil Forces in accordance with the law, and focus on cracking down on manipulating the election of the rural "two committees" by means of bribery or violence and threats, as well as indulging and sheltering the village bullies and clan evil forces, causing them to suffer serious problems, or accepting bribes, engaging in malpractices for personal gain, and so on. (Details: tremble "village bully"! Are you afraid of the top tricks?)

nine

  ④ In 2020, the number of new professional farmers will exceed 20 million.

  A few days ago, the Ministry of Agriculture issued a plan, proposing that by 2020, the total number of new professional farmers in China will exceed 20 million. With the direction of improving farmers, supporting farmers and wealthy farmers, and focusing on attracting young people to farm and cultivating professional farmers, we will accelerate the construction of a team of new professional farmers who are literate, skilled, good at management and good at management. According to the statistics of the Ministry of Agriculture, the number of new professional farmers in China is 12.72 million, an increase of 55% over 2010.

nine

  ⑤ There are new standards for furniture environmental protection.

  Since February 1st, the Technical Requirements for Environmental Labeling Products — — Furniture was officially implemented. The new version of the standard increases the requirements for raw materials of leather and artificial leather, the requirements for waste recovery and treatment in the production process, the requirements for the limit of harmful substances in solvent-based wood coatings, and the requirements for the limit of mobile elements and phthalates in products. If it can be implemented in place, the environmental protection of furniture will be greatly enhanced.

nine

  ⑥ High-level talents should flow reasonably and orderly.

  The general office of the Ministry of Education issued a notice to discourage eastern universities from introducing talents from universities in the central, western and northeastern regions; Colleges and universities should not unilaterally rely on high-paying and high-paying bidding to grab talents; It is advocated that colleges and universities agree on the maximum salary of talents in the same region. The flow of high-level talents in colleges and universities should obey the fundamental task of serving the people in virtue and the overall situation of higher education reform, development and stability, and obey the major national development strategies such as the development of the western region, the revitalization of the old industrial bases in Northeast China and the "Belt and Road".

nine

  ⑦ Lawyers’ practice will be more standardized according to law.

  The National Lawyers Association said that in 2017, the National Lawyers Association will formulate and implement the Rules for the Protection of Lawyers’ Professional Rights of Lawyers Association, further deepen the reform of the lawyer system, improve the self-discipline management and services of the lawyer industry, and promote lawyers to standardize their practice according to law. Set up a center to safeguard lawyers’ practice rights in the Bar Association to help lawyers communicate quickly and conveniently and reflect problems; At the same time, do a good job in safeguarding lawyers’ practice rights, improve the disciplinary mechanism with clear division of labor, clear responsibilities and effective operation, and form a complete management and service system for lawyers’ evaluation. (This article Source: Economic Daily)

nine

From January 1st, import and export tariffs on some medicines, raw materials and other commodities were lowered-more "zero tariffs" came.

  Since January 1 this year, tariffs have started a new round of adjustment, and "zero tariff" has become a high-frequency word-

  Implement zero tariffs on some anticancer drugs, medicines and raw materials for rare diseases; The provisional import tax rate of lithium chloride, cobalt carbonate and seed sweet corn was reduced to zero; China and Nicaragua immediately implement zero tariffs on products with about 60% of their respective tax items …

  Experts said that in recent years, the overall tariff level in China has been continuously reduced, and more and more commodities have entered the "zero tariff era", which is not only conducive to enhancing the linkage effect of the two resources in the domestic and international markets, enhancing people’s livelihood and welfare, benefiting the development of enterprises, maintaining the stability and smoothness of the domestic industrial chain supply chain, but also conducive to promoting high-level opening up and allowing the world to share more opportunities for China’s development.

  Imported goods—

  The provisional tax rates for some anticancer drugs and resource commodities are adjusted to zero.

  According to the latest tariff adjustment plan for 2024 (hereinafter referred to as the "plan"), from January 1st, China implemented a provisional import tariff rate lower than the MFN tariff rate for 1010 commodities.

  After combing this plan, the reporter found that the provisional import tax rate of some drugs and raw materials was directly adjusted to zero, such as anticancer drugs for treating liver malignant tumors, raw materials for rare diseases for treating idiopathic pulmonary hypertension, and ipratropium bromide solution for drug inhalation which can be widely used in the treatment of childhood asthma diseases in clinic.

  "The implementation of zero tariffs on some anticancer drugs, drugs and raw materials for rare diseases will help reduce the cost of drugs, reduce the burden of drugs for patients, especially cancer patients, and have more drug choices to further protect people’s lives and health." Zhang Jianping, deputy director of the Academic Committee of the International Trade and Economic Cooperation Research Institute of the Ministry of Commerce, said that in fact, in recent years, medicine has been the key area of tax reduction, and the import tariffs on many anticancer drugs, rare diseases and related raw materials have been reduced to zero.

  On May 1, 2018, China adjusted the import tariffs on some drugs and cancelled the import tariffs on 28 drugs, including many kinds of imported anticancer drugs. Relevant measures quickly took effect. In October of that year, 17 kinds of anticancer drugs were included in the medical insurance reimbursement catalogue, with an average decrease of 56.7% compared with the previous average retail price.

  Since then, China has successively cancelled a number of import tariffs on drugs and raw materials: in 2019, the provisional import tax rate of anticancer drug raw materials such as oxaliplatin, carboplatin, nedaplatin and cisplatin was adjusted to zero; In 2020, zero tariffs will be imposed on drugs for treating asthma and raw materials for producing new diabetes drugs, such as Engelgin, Liggliptin and Vigliptin; In 2021, the second batch of raw materials for anticancer drugs and rare diseases will be subject to zero tariffs; In 2022, zero tariff will be imposed on radium chloride injection, a new anticancer drug.

  It’s not just drugs that are listed as "zero tariffs". This plan also explicitly reduces the import tariffs on lithium chloride, cobalt carbonate, low arsenic fluorite, sweet corn, coriander, burdock seeds and other commodities, and the provisional import tax rate has reached zero. According to experts’ analysis, lithium chloride, cobalt carbonate and other commodities are key raw materials for the new energy automobile industry, and fluorite is an important mineral resource. The obvious reduction of import tariffs on these products will help enterprises to allocate resources on a global scale, reduce production costs and enhance the resilience of the industrial chain supply chain.

  "This tariff reduction mentioned coriander, which is often said by everyone, which is a major positive for our company’s imports." Xu Minghui, deputy general manager of Shandong Golden Seed Agricultural Development Co., Ltd. said that the company imports about 300 tons of coriander seeds every year, which used to cost about one kilogram of 15 yuan. After reducing tariffs, the import cost alone can save more than 600,000 yuan a year, which will help enterprises achieve better development.

  Free trade partner-

  The number of products with mutually cancelled tariffs has gradually increased.

  This tariff adjustment involves not only the provisional import tax rate, but also the agreed tax rate. Zero tariff is also one of the highlights.

  On January 2nd, Hubei ushered in the first "Zero Tariff" certificate of China-Nicaragua Free Trade Agreement. On the same day, Wuchang Customs, which belongs to Wuhan Customs, issued a certificate of origin of China-Nicaragua FTA for Chibi Yayuan Trading Co., Ltd., and the textile fabric certificate exported by this enterprise to Nicaragua can enjoy a tariff reduction of about 18,000 yuan from the importing country.

  Yu Yawen, head of Yayuan Company, said: "We are mainly engaged in textile fabric trade, and Nicaragua is one of the export destinations of the company. After learning that the tariff rate of textile fabrics exported to Nicaragua in 2024 can be reduced from the original 10% to zero, we handled the certificate of origin under the guidance of the customs and enjoyed this tariff dividend for the first time. "

  On January 1st this year, the China-Nicaragua Free Trade Agreement came into effect. According to the agreement, the two sides will achieve high-level mutual opening in the fields of trade in goods, trade in services and investment market access. In terms of trade in goods, the two sides will eventually implement zero tariffs on products with their respective tax items exceeding 95%, of which products with immediate zero tariffs account for about 60% of their respective total tax items. This means that when Nicaraguan beef, shrimp, coffee, cocoa, jam and other products enter the China market, the tariff will gradually drop to zero; When Chinese-made cars, motorcycles, batteries, photovoltaic modules, clothing and textiles enter the Nigerian market, tariffs will also be gradually reduced and cancelled.

  Ivan acosta, Minister of Finance and Public Credit of Nicaragua, said: "The free trade agreement signed with China is a great opportunity for Nicaragua. We believe that entering the huge market of China will enable us to develop rapidly."

  In recent years, China’s free trade "circle of friends" has been expanding. Shortly after the signing of China-Nepal FTA, China and Serbia signed a FTA, which is the 22nd FTA signed by China, and Serbia became China’s 29th FTA partner.

  According to the person in charge of the International Department of the Ministry of Commerce, the China-Serbia FTA focuses on making relevant arrangements for trade in goods, and the two sides will cancel tariffs on 90% of the tax items respectively, and more than 60% of the tax items will be cancelled immediately after the agreement comes into effect, and the final import volume ratio of zero-tariff tax items will reach about 95%. Serbia will include cars, photovoltaic modules, lithium batteries, communication equipment, mechanical equipment, refractories, some agricultural and aquatic products that China pays close attention to, and the tariffs on related products will be gradually reduced from the current 5%-20% to zero; China will include generators, motors, tires, beef, wine, nuts, etc., which are of great concern to Serbia, into zero tariffs, and the tariffs on related products will be gradually reduced from the current 5%-20% to zero.

  The new signing has been accelerated, and there have been new changes in the implementation. This year, the Regional Comprehensive Economic Partnership Agreement (RCEP) entered its third year of implementation, and 15 RCEP member countries will further reduce tariffs on products such as light industry, automobiles, electronics and petrochemicals according to the commitments of the agreement, and further increase the products that are included in zero tariffs.

  "Since the implementation of RCEP for two years, the tariff reduction bonus has been released quickly. We have used the preferential policy of origin (accumulation rule) to export to RCEP countries, saving customers more than 5 million yuan in import tariffs, effectively improving the competitiveness of our products in the international market." Han Jie, Minister of Import and Export Customs of Dongyue Group, said.

  Fan Ruojun, vice president of Guangxi Academy of Social Sciences, said that in the RCEP agreement, tariff reduction is the key content. According to the agreement, the member countries will set tariffs in pairs, gradually reduce the tariffs on more than 90% products to zero in about 10 years, and implement unified rules of origin in the region, stipulating that the value of goods’ origin can be accumulated in member countries, which will continue to promote trade liberalization and facilitation among member countries.

  Free Trade Zone Free Trade Port-

  The list of "zero tariffs" continues to expand.

  Further promote the implementation of more "zero tariff" policies, and the free trade pilot zone and free trade port are at the forefront.

  On December 29th, 2023, the Ministry of Finance, the Ministry of Commerce and other five departments issued an announcement to pilot relevant import tax policies and measures in the conditional free trade pilot zone and free trade port, which clearly stated that in the special customs supervision area where Hainan Free Trade Port implements the "first-line" liberalization and "second-line" control of import and export management system, goods temporarily allowed by enterprises to enter the pilot area for repair from abroad from the date of implementation of this announcement will be exempted from customs duties, import value-added tax and consumption tax.

  The relevant person in charge of the Ministry of Commerce said that this measure has changed the "first-line" import duty-free and re-export duty-free of goods currently entering the special customs supervision area of Hainan Free Trade Port into direct duty-free, breaking through the current bonded policy; At the same time, it will be beneficial to the development of related maintenance industries to allow the goods that are no longer shipped out of the country to be sold domestically.

  Hainan Free Trade Port has made new progress in "zero tariff" in recent years, including temporarily entering the country to repair goods. According to the latest data of Haikou Customs, since the implementation of the "zero tariff" policy for raw materials in Hainan Free Trade Port for three years, the customs has gone through the customs clearance procedures for the import of "zero tariff" raw materials, and the accumulated import value has exceeded 8.3 billion yuan, and the tax reduction has exceeded 1.1 billion yuan, effectively reducing the production and operation costs of enterprises.

  On December 1, 2020, the "zero tariff" policy for raw materials of Hainan Free Trade Port was implemented. This policy makes it clear that before the whole island is closed, enterprises registered in Hainan Free Trade Port and with independent legal person status are exempted from import duties, import value-added tax and consumption tax when importing raw and auxiliary materials used for production and self-use, production and processing activities in the mode of "two ends out" or service trade in the mode of "two ends out". Enterprises do not need to submit a guarantee, but only need to pay the import duties, import value-added tax and consumption tax of the corresponding raw materials in domestic sales, so as to meet the business needs of Hainan Free Trade Port enterprises and alleviate the financial pressure.

  Xu Lingling, chief of the Inspection and Evaluation Management Section of Haikou Customs Customs, introduced that the "zero tariff" policy for raw and auxiliary materials implemented positive list management, with the first batch of 169 listed commodities. By the end of 2021, after adjusting and adding 187 new commodities such as fresh durian, vinyl chloride and aero-engine parts, the number of listed commodities reached 356, including agricultural products such as coconut, resource products such as coal, chemicals such as vinyl chloride and parts for aircraft and ship maintenance.

  After the "zero tariff" policy for raw materials, Hainan Free Trade Port successively implemented the "zero tariff" policy for vehicles and yachts and the "zero tariff" policy for self-use production equipment. On January 5th this year, Hainan released the Measures for the Administration of Zero Tariff Imported Vehicles and Yachts in Hainan Free Trade Port (Trial), and put forward 50 specific measures.

  The relevant person in charge of the Hainan Provincial Department of Transportation said that the Ministry of Finance, the General Administration of Customs and the State Administration of Taxation recently issued a notice to adjust the "zero tariff" policy for vehicles and yachts in Hainan Free Trade Port, and added 22 items to the "zero tariff" import list. In the face of new situations and changes, the document issued this time will further enhance the adaptability of the "zero tariff" import vehicle and yacht policy.

 

  Reporter Qiu Haifeng

Giant pandas arrive in Beijing on National Day (photos)


  The National Day Giant Panda was interviewed. At 7: 10 last night, six National Day pandas arrived at the Olympic Panda Pavilion in Beijing Zoo and started their one-year trip to Beijing. "A lot of time is robbed." Zhang Jinguo, deputy director of the Beijing Zoo, said that in order to reduce the travel fatigue of giant pandas, the big trucks carrying pandas entered the Fifth Ring Road ahead of schedule. At 8 am on May 1, they will meet with tourists. Our reporter Wang Shenshe



The breeder replenished water for the National Day giant panda who just got off the plane.



The breeder from Ya ‘an leads the panda into the barn of Beijing Zoo.



After the giant pandas arrived in Beijing on the National Day, the quarantine officers were visually inspecting their health.



  A giant panda climbed up the railing as soon as it entered its new home on National Day. Yesterday afternoon, six National Day giant pandas arrived in Beijing, and will meet with tourists at 8 am on May 1.



The truck carries the giant panda on National Day to the zoo.


  Time: afternoon of April 29th.


  Venue: Capital Airport to Beijing Zoo


  Event: Six National Day pandas arrived in Beijing.


  At 7: 10 last night, six National Day pandas arrived at the Olympic Panda Pavilion in Beijing Zoo and started their one-year trip to Beijing.


  At 7 o’clock yesterday morning, the panda was caged and transported from Ya ‘an to Chengdu Shuangliu Airport, and flew to Beijing in the afternoon. At 4: 37 pm, the plane landed. In the next two and a half hours, the staff quickly completed the process of delivery, quarantine and transportation.


  "A lot of time is robbed." Zhang Jinguo, deputy director of the Beijing Zoo, said that in order to make the pandas feel less tired during the journey, trucks carrying pandas also drove into the Fifth Ring Road during the no-go period.


  At 8: 00 am on May 1, six National Day pandas will meet with tourists.


  The delivery time is shortened by 1 to 2 hours.


  At 5: 33 pm yesterday, six National Day giant pandas were transported to the cargo terminal of the Capital Airport.


  "The normal delivery time takes 2 to 3 hours." Lu Lili, deputy general manager of Air China’s Beijing operation base, said, however, the delivery of national treasures is a special event, so it is one to two hours shorter than the normal delivery time.


  Outside, Zeng Youlin, deputy section chief of the air transport quarantine supervision department of Beijing Animal Health Supervision Office, is waiting. The transport of live animals must be stamped with the aviation visa and personal stamp by the quarantine supervision station of the capital airport where he is located before he can pick up the goods and enter Beijing.


  Zeng Youlin said that it is necessary to check the quarantine certificate issued by the place of origin first, and then visually observe the health of the animals.


  About five minutes later, the pandas successfully obtained the "passport" to Beijing. Generally, this process takes about 1 hour.


  The van carrying the panda broke through the Fifth Ring Road in advance.


  When Zeng Youlin inspected the goods, the breeder Yang Haidi lost no time to feed the pandas with mineral water, apples, carrots and other things.


  "Mainly to replenish water." Yang Haidi said that six giant pandas didn’t drink water all afternoon. At about 7: 20 am yesterday, they were caged and fed once after arriving at Chengdu Shuangliu Airport from Ya ‘an.


  At 5: 50 pm, the giant panda was loaded and went to Beijing Zoo.


  As the truck is in the no-go period, the driver suggested finding a place to park to avoid violating the rules.


  "Can’t wait any longer." Zhang Jinguo, the accompanying deputy director of Beijing Zoo, felt that the pandas should be sent to the zoo as soon as possible to have a good rest. He decided to venture into the Fifth Ring Road. If the police intercepted him, he would try to win the understanding of the other party. If he was photographed by an electronic eye, the fine would be reimbursed by the unit.


  In this way, take the airport north line, Jingcheng Expressway, North Third Ring Road to Lenovo Bridge, take Zaojunmiao Road, and enter Beijing Zoo from the north gate.


  "Look, it’s a giant panda." Along the way, many vehicles followed the transporter and took out cameras and DV to shoot.


  At 7: 05 last night, the van carrying giant pandas stopped in front of the Olympic Panda Pavilion. Subsequently, six giant pandas were carried into the animal house and enjoyed dinner.


  Zhang Jinguo said that they will meet the tourists at 8 am on May 1.


  This edition was written/Our reporter Lin Wenlong This edition of photography/Our reporter Wang Shen

Editor: Li Xiuwei

24 Wuling Binguo are on the market for 56,800!

24 sincere 56,800

The 2024 model was officially launched on June 14th, and four models were launched, with the price range of 56,800-84,800 yuan. Here are some features of this car:

Appearance: It continues the design style of the old models. The front face is closed, the headlights are round, and it looks very cute with the compact body. Snow Mountain white paint is added to the 203km light-duty model. The body size is 3950mm×1708mm×1580mm, and the wheelbase is 2560mm. The new car also provides 15-inch wheels, compared with 185/60R15 in tyre size.

Interior: We will continue to use the dual-control screen consisting of a double-width steering wheel and a 10.25-inch LCD instrument+a 10.25-inch central control screen (only the 7-inch LCD instrument is equipped for middle and low models). The Linxi model is equipped with Ling OS Linxi car system, adding entertainment applications such as iQiyi. The 333km and 410km endurance models have added green color matching in the air.

Power system: equipped with front single motor, divided into high and low power. Among them, the 333km and 410km endurance models are upgraded with water-cooled flat wire motors, which have stronger heat dissipation capacity, the maximum power is still 50kw, and the maximum speed is increased from 120km/h to 130 km/h; The 203km endurance car is still equipped with a 30kw single motor with a maximum speed of 100 km/h. The new car comes standard with DC fast charging, and it takes only 35 minutes to charge 30%-80%. In terms of battery life, the battery packs with three capacities, namely 17.3kwh, 31.9kwh and 37.9kwh, are matched, corresponding to CLTC’s pure electric cruising range of 203 km, 333 km and 410 km.

Space: The wheelbase is at the leading level in the same class. Thanks to the high utilization rate of passenger compartment space, it can bring ample space experience to users. The trunk of the car is designed to be sunken, and the volume of the rear seat can reach 1240L after being put down as a whole, and 15 storage spaces are also designed in the car.

Configuration: It has the functions of remote car control and voice control by mobile phone app, and some models have electric adjustment of the main driver’s seat, keyless entry, electronic, cruise control, reversing radar, exterior rearview mirror with heating and defogging function, etc.

In addition, the new car also provides certain car rights, including 2000 yuan financial discount or replacement subsidy (one of the two choices); Give a 3.5kw charging pile (with installation conditions); The first non-operating vehicle owner has a lifetime warranty of Sandian (the whole vehicle is guaranteed for three years or 100,000 kilometers).

The actual car experience of some car owners is shared as follows:

A car owner said that Wuling Binguo was chosen mainly to facilitate the daughter-in-law to go to work and pick up the children, and its price was satisfactory, and the landing price was less than 90,000. The appearance of the vehicle is lovely and is liked by the daughter-in-law; The interior has a double screen and knob shift, which has a strong sense of science and technology, as well as a blue+black color scheme with a "small and fresh" style. In terms of space, a family of three is very spacious. People with a height of 178cm sit in the back row, and the leg space is close to a punch. The trunk can easily put down camping equipment such as awning, barbecue grill and folding chair. In terms of configuration, the remote car control function of the mobile app is practical, which can turn on the air conditioner in advance, and the voice car control can control navigation, music, etc., which is very convenient. Full of power, it is completely enough in urban roads, and it has a sense of pushing back, and the cost of electricity is extremely low, about 5 cents per kilometer.

Another car owner said that he bought a car for transportation. He thought that Wuling Binguo had a high face value and was more handsome after adding a black top, but it was a bit ostentatious to drive on the street. The car has a spacious space, large internal space, and can place all kinds of articles at will. It is not crowded when it is full, and the trunk is large, which has won praise from others. The vehicle is easy to drive, friendly to novice drivers, soft and comfortable to drive, small and available, and it is not difficult to drive and park. Configuration, there are voice car control, mobile app control and other functions, which can be unlocked by mobile phone Bluetooth, turn on the air conditioner in advance, and control navigation, charging and listening to music through voice, which is very easy to use.

Some car owners mentioned that Wuling Binguo is exquisite and retro, adding snow-capped white car color and empty green interior color matching, and there are more choices. Compared with, the appearance of Binguo is more popular with young female consumers, and it provides a two-color body; It has more advantages in space, longer wheelbase, more friendly rear space and larger trunk volume; Equipped with large-size Dalian screen, LingOS Linxi system is rich in entertainment applications. In terms of power, it provides a variety of endurance options, and the whole system comes standard with DC fast charging, which has high energy replenishment efficiency and good endurance achievement rate and energy consumption performance in endurance measurement. At the same time, 24 models of Binguo have upgraded the three-in-one water-cooled flat wire motor in the redesign, and the maximum speed has increased to 130 km/h. It also takes care of the user groups who need large space, long battery life and low car purchase cost, and provides a 203km version with fast charging as standard. On the whole, the design of 24 Binguo products has taken care of more consumers’ aesthetics. This time, the price reduction and allocation have been realized, and the comprehensive cost performance has been improved.

The top 100 Chinese Internet companies in 2019 were announced, and Alibaba Tencent Baidu ranked among the top three

  On August 14, the Internet Society of China and the MIIT Information Center jointly released the 2019 list of China’s top 100 Internet companies, the list of the top 20 Internet growth companies, and the 2019 China Top 100 Internet Companies Development Report.

  Alibaba (China) Co., Ltd., Shenzhen Tencent Computer System Co., Ltd., Baidu, JD.com Group, Zhejiang Ant Small and Micro Financial Services Group joint stock company, NetEase Group, Meituan Dianping, Beijing ByteDance Technology Co. Ltd., 360 Security Technology joint stock company, Sina Company ranked among the top ten.

  MIIT said that this year’s top 100 Internet companies focus on innovation leadership, industrial integration, industrial Internet, etc., and mainly exhibit six characteristics:

  First, the overall scale has been leapfrogged to become a new engine of the digital economy.In 2019, the Internet business income of the top 100 Internet enterprises reached 2.75 trillion yuan, which was more than 1 trillion yuan compared with the Internet business income of the top 100 Internet enterprises in 2018, accounting for 8.8% of our country’s digital economy, and the contribution rate to the digital economy reached 14%. Driving the growth of the digital economy by nearly 2 percentage points has become an important support for the development of the Internet industry in our country. From the distribution of the growth rate of Internet business income, 86 enterprises have achieved growth in Internet business income.

  The second is to break through 10% in R & D investment to build China’s core technologies.In 2019, the R & D investment of the top 100 Internet enterprises reached 153.87 billion yuan, an increase of 45.1% year-on-year, and the average R & D intensity exceeded 10%, which was nearly 8 percentage points higher than the R & D investment intensity of our country. From the distribution of R & D intensity, there are 40 enterprises with R & D intensity above 10%, and 4 enterprises with R & D intensity between 30% and 35%. The top 100 Internet enterprises continue to break through core technologies. The top 100 Internet enterprises continue to improve their original innovation capabilities, and accelerate the breakthrough of key core technologies such as 5G, artificial intelligence, cloud computing, and big data. Some technologies are at the international leading level. In 2019, the top 100 Internet enterprises have nearly 80,000 patents, including nearly 60,000 invention patents. In 2019, there were 29 big data companies, 28 cloud computing companies, 24 artificial intelligence-related companies, and 3 companies related to the use of Internet of Things technology among the top 100 Internet companies.

  The third is the diversification of application scenarios, and smart + creates a new model of life consumption.The top 100 Internet enterprises have deepened the development of consumer Internet, and have carried out full-scene coverage of clothing, food, housing, transportation and other aspects. Their business covers 17 fields such as Internet public services, online media, music and video, social network, scientific and technological innovation and intellectual property rights, and has comprehensively improved the quality of life of the people in terms of life, work, culture, entertainment, education and other aspects. In 2019, a total of 18 Internet top 100 enterprises engaged in e-commerce; a total of 41 involved in Internet public services, mainly providing convenient services such as information inquiry, education and medical care, government affairs management, and public travel, so that ordinary people can enjoy the convenient life brought by "Internet +"; 21 enterprises are involved in music and video business. At the same time, the top 100 Internet companies are actively developing smart industries, continuously expanding "smart +", creating a wealth of new consumer formats and scenarios such as smart stores, VR/AR fitting, and non-sensory payment, creating a new model of smart life consumption in the future.

  Fourth, the industrial Internet is deeply cultivated into practice and empowers the high-quality development of traditional industries.By continuously "infiltrating" and "empowering" all walks of life, the top 100 Internet enterprises promote the in-depth integration of Cloud Computing, Big Data, Internet of Things and other Information Communication Technologies with the real economy, cultivate new industries, new business formats and new models, and support the high-quality development of the real economy. In 2019, the number of industrial Internet enterprises in the top 100 Internet enterprises reached a new high, and the number of industrial Internet enterprises mainly serving real economy customers reached 60, and the cumulative service was nearly 40 million enterprises. Among them, 41 involved Internet data services, 13 manufacturing services, 24 technological innovation and intellectual property rights, 11 B2B e-commerce, and 10 Internet basic services.

  Fifth, "unicorn" enterprises have grown rapidly, and their international industry status has reached a new high.In 2019, 25 unicorn companies such as Ant Financial, ByteDance, JD.com, Mangbang Group, Youkede, and Wansteel emerged among the top 100 Internet companies and their subsidiaries, an increase of 38.9% year-on-year. Their business involves financial technology, smart logistics, e-commerce, new entertainment and other fields. From the perspective of the market value ranking of global companies, in 2018, the top 30 Internet companies in the global market value accounted for 10 Internet companies. Among them, Tencent Group and Alibaba firmly ranked among the top ten global Internet companies in market value.

  Sixth, the coverage area has been newly expanded, and online poverty alleviation has achieved new results.In 2019, the number of provinces with top 100 Internet enterprises reached 18. On the basis of 2018, two new provinces, Jiangxi and Shandong, were added, and the geographical coverage continued to increase. In terms of regional distribution, the number of top 100 Internet enterprises in the eastern region totaled 86, the number of top 100 Internet enterprises in the central and western regions totaled 12, and the number of top 100 Internet enterprises in the Northeast region remained 2. Among them, the number of top 100 Internet enterprises in Anhui, Guizhou, Henan, Hubei, Hunan, Jiangxi, Chongqing, and Sichuan in 8 central and western regions continued to increase, an increase of 1 over last year. The top 100 Internet companies actively practice corporate social responsibility, give play to the role of the Internet in boosting poverty reduction, explore new poverty alleviation models such as "live broadcast + e-commerce", and promote targeted poverty alleviation and targeted poverty reduction. According to statistics, more than half of the top 100 Internet companies participate in online poverty alleviation.

  The following is the complete list of the top 100 Internet companies:

1

  In addition, this year’s top 20 Internet growth enterprises focus on high growth, active investment and financing, and diverse business formats, mainly presenting three major characteristics:

  First, the revenue growth of Internet companies is strong.In 2019, China’s top 20 Internet growth enterprises grew rapidly, and their operating income reached 12.887 billion yuan, an increase of 435.44% year-on-year, which is 7.2 times the growth rate of China’s top 100 Internet enterprises. Among them, 85% of the enterprises’ operating income growth rate exceeded 100%. Growth enterprises 20 attach great importance to innovation and development, and continue to increase R & D investment to achieve accelerated iterative updates of industrial products or services. The total number of R & D personnel reached 3,819, accounting for nearly 40% of the total number of employees of the enterprise, an increase of 46.83% year-on-year. The R & D intensity was 16.2%, which was nearly 6 percentage points higher than that of China’s top 100 Internet enterprises.

  Second, investment and financing activities are highly active.As a representative of our country’s growth enterprises, the top 20 growth enterprises have been established for a short time, with an average establishment time of only 7 years, which is 6.3 years less than the top 100 Internet enterprises. The huge investment and financing provides a guarantee for the rapid development of enterprises. In 2019, 9 of the top 20 growth enterprises completed financing activities, with a total financing amount of 11.319 billion yuan.

  The third is the emergence of diverse business models.China’s top 20 Internet growth enterprises have dug deep into consumer Internet demand, followed the development trend of industrial Internet, and produced many new industries, new products and new services that can meet the needs of the people, which has contributed a lot to the development of our country’s digital economy. In 2019, the top 20 growth enterprises covered 12 industries such as Internet public services, Internet data services, network marketing and e-commerce, and a number of new business forms and new models such as agricultural Internet and intellectual property services have emerged in the top 20 growth enterprises, which have become an important support for promoting the development of digital economy.

  Here is the complete list of the top 20 Internet growth companies:

Best Andy Lau Returns, Annual High Film "Blind Detective" Exposes Ultimate Poster


The Ultimate Poster for Blind Detective
    The familiar Andy Lau is back! Starring Andy Lau and Cheng Xiuwen, the annual High film directed by Du Qifeng and Wei Jiahui has been confirmed for release on July 11. The film is the fourth collaboration between Du Qifeng, Lau and Cheng Xiuwen in a decade after 2004. Yesterday, the film launched the ultimate poster, and the two-person photo of Lau and Cheng Xiuwen has made the film highly anticipated. Lau admitted that being with Du Qifeng and Cheng Xiuwen is the "best Andy Lau". He said: "I think we are all lucky to have the three of us in the world."

"Blind Detective" mainland horizontal poster
 
"Handsome Blind" Detective Du "Possessed"
 
    In this new "Iron Triangle" film, Andy Lau’s "blind detective" is a very interesting role. According to the screenwriter Wei Jiahui, at a backstage of the Hong Kong Film Awards many years ago, Andy Lau talked to him about his interest in the story of "detective". "Later, when I was designing the character, I found that he had not played a blind man, and Andy’s original idea was to play a blind lawyer." However, considering the entertainment of the film itself and the richness of the story, the screenwriter said: "If it is only a lawyer, it may only appear in a few limited scenes in the courtroom, and the blind detective has a lot of stories to tell."
 
    In the character design of the "blind detective" corner, Galaxy Image specially projected many "shadows" of the director Du Qifeng, such as Du wiping his sweat with a handkerchief, stroking his belly with his hands and other "small movements" in life. Wei Jiahui also revealed that Du Qifeng in his life is still a very fond of food, and this time his "foodie" characteristics are also "grafted" into the character. In this regard, Andy Lau also responded: "Every time I act, if the character has a characteristic, I will ask someone around me to be a model, and I will choose our director for this play – Du Qifeng."
 
"Iron Triangle" returns to the screen after a decade
 
    It is understood that "Blind Detective" is the fourth collaboration between Du Qifeng, Andy Lau and Zheng Xiuwen in ten years after "Dragon and Phoenix Fight". Hua Zai teased Zheng Xiuwen: "She basically hasn’t changed, but she has become thinner." He also emotionally expressed the trust and tacit understanding of the three creators. "With the appearance of the three of us in the world, I think it is lucky for us, and it is difficult to find someone who believes in you."
 
    Regarding the new work, Johnnie To commented: "Andy Lau was in very good condition when he made this film. I haven’t worked with him for nearly 10 years, but this time it can be said that it is the best film I have worked with him in so many years." Regarding Andy Lau and Zheng Xiuwen, a classic couple on the big screen, the director also praised: "When they are acting, I sit next to them. I like to watch the two of them as if they are really a couple. As a director, I think it is good to shoot them directly."
 
    The special rapport between the three has given "The Blind Detective" more chemistry. At the previous overseas premiere in Cannes, some people commented that "Andy Lau with Johnnie To is the best Andy Lau." In response, Andy responded that the "chemistry" between them is different from other people’s cooperation, and the tacit understanding and nature seem to be "innate". After watching "The Blind Detective", the famous film critic Magasa said that "your favorite Johnnie To is back, this film is reminiscent of, and Liu Zheng’s romantic comedy series, very good."