作者： admin

Zhanrui T760 Evaluation： Does domestic self-developed 5G core surpass Qualcomm Snapdragon？


mobile.zol.com.cn
true

https://mobile.zol.com.cn/873/8732588.html
report
1529
Today, let’s talk about an interesting entry-level mobile phone processor: Zhanrui T760. Some friends may not be familiar with this domestic mobile phone processor manufacturer. According to official website, this is a domestic enterprise that designs positioning platform chips. It has core technologies in the field of 5G, and it is one of the few manufacturers in the world that can design 5G mobile phone SoC chips by itself. Today, we are evaluating this model. …

Build a new service system with high quality and high efficiency ｜ Accelerate the digital transformation of service industry

General Secretary of the Supreme Leader pointed out during his inspection tour in Jiangsu in July this year that the digital economy should be deeply integrated with advanced manufacturing and modern service industries. Report to the 20th CPC National Congress of the Communist Party of China pointed out that a new service industry system with high quality and high efficiency should be built. Service industry is an important part of China’s economic and social development, and it is also a key link to achieve high-quality development. Under the current background, upgrading the digital development level of service industry has become the only way to upgrade the development level of service industry and build a new system of service industry development.

First, it is of great significance to accelerate the digital transformation of the service industry in the new era and new journey

China has entered a new journey of building a socialist modern country in an all-round way. As an important source of economic growth and an important way to improve the total factor productivity, the digital economy is not only an important carrier to promote the continuous expansion of the "quantity" of the service industry, but also an important support to ensure the continuous improvement of the "quality" of the service industry.

First, digitalization is the leading force to enhance the competitiveness of the service industry.With the in-depth implementation of innovation-driven development, the digital economy, as the most innovative technical field at present, is constantly improving its leading and driving ability to the service industry.One isThe emergence of new digital technologies is accelerating, and the speed of innovation iteration is constantly improving. A large number of innovations no longer have to be solidified into hardware to form products before they can enter the market. At present, the most important new technologies, such as big data, blockchain and artificial intelligence, are mainly manifested in the service industry format. The service industry has become the main battlefield for new technologies to play a leading role, and it has also become a priority for their empowerment and development.The second isThe rapid development of information technology service industry with digital technology as the main body has become an important driving force for the growth of service industry. In the past three years, the average annual growth rate of information transmission, computer service and software industry is more than double that of the service industry as a whole. In 2022, the proportion of this industry in the service industry was only 7.5%, but the average growth contribution rate in the past three years reached 14.1%.The third isDigital technology is organically integrated with the service industry in an empowering way, which has become an important means to improve the quality and efficiency of the service industry. In 2022, the digital penetration rate of China’s service industry reached 44.7%, which was higher than that of agriculture (10.5%) and industry (24.0%), making it the fastest growing area of digital transformation among the three industries.

Second, digitalization is an important way to expand the coverage of quality service industry.Digital technology innovation allows the supply of high-quality service industry to cover more people, and also leads the supply-side innovation of service industry to form more high-quality supply.On the one hand,Digital technology lowers the threshold of participation, improves the efficiency of supply and demand docking, and promotes the wide coverage of potential people. By the end of 2022, the number of users of online shopping, online take-out, online car rental and online medical care in China has reached 850 million, 520 million, 440 million and 360 million respectively. Digital technology not only enables large-scale consumers to efficiently match service supply, but also enables quality services to stand out through the screening of many consumers.On the other hand,Digital technology effectively activates high-quality niche markets. Due to the increasingly diverse market demand and the increasingly prominent characteristics of differentiated and personalized service demand, the voice of niche market and low-frequency demand is getting higher and higher. With the characteristics of high speed, low cost and wide coverage, digital technology can accurately match the needs of market niche, thus quickly reaching the minimum economic scale of service supply. In recent years, a number of high-quality long-tail market fields of service industries such as research tours and audio dramas have emerged.

Third, digitalization is a powerful starting point for expanding the new space for service industry development.Digital transformation has brought about a great change in the operation mode of service industry, and formed a new huge development space outside the traditional business.On the one hand,Digital technology can effectively expand the development space of service industry by creating a new parallel data market. Massive data is widely collected and used, creating the application value of accurate data, and the new channel of realizing is advertising push formed by consumers based on the attention of content value.On the other hand,The wide application of digital technology in the service industry has crossed the barrier that the production and consumption of the service industry are inseparable, making many traditional non-tradable service departments tradable and bringing new opportunities for the development of the service industry. Online video and online music can continue to generate consumption income by paying a production cost. At present, these two fields have covered 1.03 billion and 680 million people respectively, and the market space is extremely huge. In addition, under the digital empowerment, China’s service trade exports have continued to grow rapidly, with a total increase of 45.8% in the past three years, bringing new overseas development space.

Second, two efforts will be made to accelerate the digital transformation of the service industry

On the one hand,Consolidate the digital base of service industry. The digital base of service industry includes key areas such as elements, platforms and infrastructure. Specifically:One isFully activate the value of data elements, strengthen the open sharing of public data on the premise of ensuring data security, encourage social forces to tap the value of commercial data, and accelerate the cultivation of professional data service providers.The second isPromote the co-construction and sharing of digital technology innovation resources, encourage the development of new digital service infrastructure platforms such as open source communities and open source code hosting platforms, and optimize the digital transformation ecology of the service industry.The third isImprove the basic platform of urban information model (CIM), build the urban three-dimensional spatial data backplane, and improve the digital level of urban transportation, commerce, culture, tourism and other service facilities. We will speed up the construction of a real-life 3D China and a national spatial basic information platform, build a unified national geospatial base and data fusion platform, and improve the spatio-temporal information service infrastructure.

On the other hand,Classification promotes the digital transformation and application of service industry.One isFocus on the needs of industrial transformation and upgrading, and promote the digital transformation of producer services such as R&D design, financial services, transportation, supply chain management, energy conservation and environmental protection. Build a number of digital production service clusters, select a number of typical cases in the fields of intelligent factory construction and operation, innovative application of industrial Internet, flexible manufacturing, etc., and promote the expansion of quality supply of productive services.The second isFocusing on meeting diversified and high-quality living needs, we will accelerate the enrichment of digital application scenarios of life service industries such as commerce, culture, tourism, health, childcare, housekeeping and sports. We will promote inclusive "using numbers to empower wisdom", innovate the supply of digital services, and promote the digital transformation capacity building of service enterprises. Support all localities to cultivate digital brands and benchmarks for life service industries such as digital commerce, digital education, digital travel, digital culture, smart tourism and digital health.(Author: Zhang Zhenyi, Deputy Director of Information and Industry Development Department of National Information Center, and Zhang Liyi, Senior Analyst of Information and Industry Development Department of National Information Center)

Vanke is in trouble again!

According to China Real Estate News, recently, a statement by Pengjin Institute on delaying payment caused Vanke to fall into a storm again.

On July 1, Pengjin’s parent company, Shenzhen Pengding Chuangying Financial Information Service Co., Ltd. (referred to as "Pengding Chuangying") issued a statement saying that it provided services for multi-phase equity income investment products, and due to market factors, the investment projects could not be repaid as planned, resulting in delayed payment of some products.

The statement did not disclose the specific information of deferred payment products. However, according to feedback from many investors on social platforms, there are dozens of overdue products, including Huijiaxing, Hongcheng, Jiacheng and Beiping. One of the major reasons for the delay in payment of Pengjin’s products comes from the common identity of many investors-former employees or current employees of Vanke.

"Adhering to the principle of maximizing the interests of customers, the company is making every effort to formulate special plans with relevant parties, actively promoting fund-raising to ensure the interests of customers, and the current situation is controllable. We know that your financial security and interests are the top priority of our service, and we promise to actively promote the resolution of the incident in a highly responsible manner. " Pengding Chuangying said in the statement.

"We are not pursuing high interest rates. Last year, when we deposited money in the bank, we could have a 4% yield. We only deposited money in Pengjin with a 5% yield based on our trust in Vanke. With the expansion of the influence of the incident, many departments intervened. Pengjin promised to give a solution these days, and we are willing to wait. " An investor said.

Redemption crisis

Pengjin Institute, the full name of Shenzhen Pengjin Institute Internet Financial Services Co., Ltd., is an internet financial platform jointly built by Vanke and a number of listed companies; It is also a wholly-owned subsidiary of Pengding Chuangying.

"Many Vanke employees have purchased Pengjin products, ranging from four or five million yuan to three or four hundred thousand yuan." An investor quoted the account manager as saying that since March this year, more than a dozen products of Pengjin have been thundered, involving an amount of about 700 million yuan to 800 million yuan. Pengjin’s investment platform has provided a liquidity commitment letter, but it has not fulfilled its liquidity support obligations as promised.

A former Vanke employee wrote on the Internet platform: "Last year, I bought (Pengjin Institute) financial products, 200,000 yuan, with a one-year annual interest of 5.2%. It should have been paid in May this year. On the day of maturity, I directly informed that I was financially nervous and could not pay, so I had to postpone it."

Another important factor that this incident caused concern was the connection between Pengding Chuangying and Vanke.

According to the enterprise investigation information, Pengding Chuangying has 28 shareholders, among which Shenzhen Vanke Financial Consulting Company (a wholly-owned subsidiary of Vanke) holds 20.0669% of Pengding Chuangying’s shares. Guo Changyu, the legal representative of Pengding Chuangying, once served as the director of Shenyang Vanke Yongda Real Estate Development Co., Ltd. Although the company has been cancelled, Guo Changyu is still a member of Vanke Group. In addition, Zhu Jiusheng, President of Vanke Group, served as Chairman and General Manager of Pengding Chuangying from September 2016 to February 2018. All this information shows the connection between the two.

However, the reporter learned from a person close to this matter that Vanke only holds 20% of Pengding Chuangying’s shares, which did not reach the holding line. It is not a controlling shareholder, but only entered as a strategic investor. There are not many Vanke employees who buy Pengjin’s related wealth management products, and the amount is limited, and it is voluntary, not mandatory; Related wealth management products are not only for Vanke employees, but also for others. In fact, in recent years, the market situation is not good, and few Vanke employees buy this product. Moreover, Pengjin’s overdue product does not involve Vanke’s standard debt default.

According to the Company Law, the controlling shareholder refers to the shareholder whose capital contribution accounts for more than 150% of the total capital of the company or whose shares account for more than 50%; Shareholders whose capital contribution or shareholding ratio is less than 50%, but whose voting rights are sufficient to have a significant impact on the resolutions of the shareholders’ meeting.

Wu Xindong, a partner of deheng law offices, said that according to this regulation, the largest shareholder is not necessarily the controlling shareholder, depending on whether the shareholding ratio exceeds 50% or whether other arrangements have a significant impact on the resolution of the shareholders’ meeting. Shenzhen Vanke Financial Consulting Co., Ltd. holds 20% equity of Pengding Chuangying, and is not the controlling shareholder from the perspective of equity structure. According to the Company Law, generally speaking, shareholders are only limited to the amount of capital contribution, so Vanke, as an indirect shareholder in law, has no legal obligation to pay.

Vanke is involved.

However, Vanke is still pushed to the forefront.

According to the data, Pengding Chuangying was established in June 2014 with a registered capital of 527.78 million yuan. The lead unit is Shenzhen Gaoxintou Venture Capital Co., Ltd., a subsidiary of Shenzhen Gaoxintou Group Co., Ltd., and its shareholders include Shenzhen Gaoxintou Venture Capital Co., Ltd., as well as 22 domestic and foreign listed companies such as Tianyuan Dike, Wal-Mart Nuclear Materials, Kelu Electronics, Hainengda and xing sen technology, and the enterprises controlled by the actual controllers of listed companies. 22 listed companies each hold 3.79%, accounting for 83.38% of Pengding Chuangying’s total share capital.

Due to its strong shareholder background and the advantages of resource integration among shareholders, Pengjin Institute was once praised by the media as the "aircraft carrier" of Internet finance. Pengding Chuangying profile wrote that Pengjin Institute is committed to guiding private funds to support the development of the real economy, broadening financing channels for small and micro enterprises, helping small and micro enterprises solve financing difficulties, and providing investors with a safe return on investment.

Vanke’s shareholding in Pengjin Institute began in 2016, when Internet finance was booming, and many developers built their own real estate financial platforms. In August 2016, Pengding Chuangying completed the capital increase and share expansion, and Vanke made a strategic investment of about 300 million yuan to become the largest shareholder.

Also in September 2016, Zhu Jiusheng, who resigned as vice president of Vanke, became the chairman and general manager of Pengding Chuangying. According to reports, after Zhu Jiusheng entered the company, Pengjin Institute launched the "Pengjinxin" real estate and investment and loan project in early 2017. Most of the borrowers were employees of Vanke, and the funds were earmarked for "follow-up investment in real estate development projects of their enterprises".

According to reports, on November 28, 2017, Zhu Jiusheng made his last public appearance as the chairman of Pengding Chuangying. At the launching ceremony of "Caizhu", a building materials B2B third-party procurement trading platform jointly initiated by Vanke, Zhongcheng Investment, Zhongtian Group and Zhonghe Ruimin, he said that the balance sheet space of real estate developers, suppliers and general contractors is limited. With such a platform, there will be new supply chain thinking and securitization thinking, which will allow commercial credit to flow in society through the platform and exceed the limit of its own balance sheet.

After Vanke entered the company, Pengjin Institute played a great role in financing Vanke’s projects. However, with the sharp decline of the industry situation, the once brilliant Pengjin Institute is also facing a redemption crisis.

In fact, since the second half of 2017, a large number of products related to real estate have begun to appear overdue, including products of Evergrande Fortune and Zhongzhi Department. Because the underlying assets of many financial P2P trusts are real estate, it leads to a chain reaction.

Now it seems that Pengjin’s strong shareholder background is not reliable.

On July 3, according to the documents disclosed by the Hong Kong Stock Exchange, BlackRock’s long position in Vanke’s H shares decreased from 5.05% to 4.68% on June 28. As a leading asset management company in the world, BlackRock’s position changes may attract market attention.

Original title: Vanke, caught in the storm again!

Joint statement of People’s Republic of China (PRC) and the Republic of Tajikistan on developing comprehensive strategic cooperative partnership in the new era

　　Xinhua News Agency, Dushanbe, July 5th

Joint statement of People’s Republic of China (PRC) and the Republic of Tajikistan on developing comprehensive strategic cooperative partnership in the new era

　　At the invitation of President emomali rakhmon of the Republic of Tajikistan, the Supreme Leader of President People’s Republic of China (PRC) paid a state visit to the Republic of Tajikistan from July 4 to 6, 2024.

　　The two heads of state held talks in a traditional cordial and friendly atmosphere and exchanged views extensively and deeply on mutually beneficial cooperation between People’s Republic of China (PRC) and the Republic of Tajikistan (hereinafter referred to as "the two sides") and international and regional issues of common concern.

　　The two sides agreed that China-Tajikistan comprehensive strategic partnership has maintained a high level and set a good example for neighboring countries.

　　The two sides stressed that, We will abide by the Treaty of Good Neighborliness, Friendship and Cooperation between People’s Republic of China (PRC) and the Republic of Tajikistan signed on January 15, 2007, the Joint Declaration of People’s Republic of China (PRC) and the Republic of Tajikistan on Establishing Strategic Partnership signed on May 20, 2013, and the Joint Statement of People’s Republic of China (PRC) and the Republic of Tajikistan on Establishing Comprehensive Strategic Partnership signed on August 31, 2017. The Joint Statement of People’s Republic of China (PRC) and the Republic of Tajikistan on Further Deepening the Comprehensive Strategic Partnership signed on June 15, 2019 and the Joint Statement of People’s Republic of China (PRC) and the Republic of Tajikistan signed on May 18, 2023 hold that these documents have laid a solid legal foundation for the sustainable development of bilateral relations.

　　The two sides pointed out with satisfaction that the frank, mutual trust and constructive high-level exchanges between the two countries over the past 10 years, as well as the cooperation mechanisms established in the fields of political diplomacy, economy and trade, and humanities, have ensured the smooth development of China-Tajikistan relations.

　　Based on the common desire of high-level cooperation and deepening bilateral relations between the two countries, the two sides are committed to building a community of destiny of friendship for generations, solidarity and mutual benefit.

　　Based on the current development needs of China-Tajikistan relations, the two sides decided to develop a comprehensive strategic partnership of cooperation in the new era and made the following statement:

　　one

　　People’s Republic of China (PRC) and the Republic of Tajikistan have successfully embarked on independent national development and national rejuvenation.

　　China spoke highly of the achievements of the Republic of Tajikistan in consolidating national sovereignty, security and territorial integrity and promoting peaceful foreign policy under the leadership of President emomali rakhmon. As always, China firmly supports Tajikistan’s independent choice of development path and respects Tajikistan’s open, pragmatic and peaceful foreign policy.

　　塔方高度评价在中华人民共和国主席最高领袖领导下，中国正以中国式现代化全面推进中华民族伟大复兴，为维护世界和平、稳定和可持续发展作出重大贡献。

　　双方重申，将坚决致力于拓展各领域合作，进一步巩固睦邻友好，促进共同繁荣。

　　双方将不断巩固政治互信，加强互利合作，及时有效应对地区安全和可持续发展所面临的挑战与威胁。

　　双方将全面贯彻落实两国元首达成的共识，保持密切高层往来，确保政府间、地方间和民间交往机制有效运作。

　　双方愿充分发挥两国主管副外长磋商机制作用，就中塔关系发展、两国各领域合作和双方共同关心的问题保持密切沟通。

　　双方将在方便时举行两国外长会晤，会晤日程和议题将通过外交渠道商定。

　　塔方重申坚定不移恪守一个中国原则，承认世界上只有一个中国，台湾是中国领土不可分割的一部分，中华人民共和国政府是代表全中国的唯一合法政府，反对任何形式的“台湾独立”，坚定支持中方为维护主权和领土完整，实现国家统一所作的一切努力。

　　As always, China firmly supports Tajikistan’s independence, sovereignty and territorial integrity, and supports Tajikistan’s efforts to safeguard national security, stability, development and prosperity and promote the values of all mankind.

　　The two sides are willing to continue to support each other on issues involving core interests such as national sovereignty, security, inviolability of borders and territorial integrity.

　　The two sides will fulfill their obligations and will never allow a third country or any organization or group to engage in acts that damage the sovereignty, security, border and territorial integrity of the other country in their own territory.

　　The two sides oppose politicization and double standards of human rights issues, oppose using human rights issues as a tool to interfere in the internal affairs of sovereign countries, and are willing to jointly promote the constructive development of human rights.

　　two

　　The two sides believe that close exchanges and mutual trust dialogue between the legislatures of the two countries are an inseparable part of China-Tajikistan relations, and strengthening bilateral and multilateral cooperation between the legislatures is of great significance to the development of comprehensive strategic partnership of cooperation in the new era and the good-neighborliness and mutual trust between the two countries and their peoples.

　　The two sides support the continued consolidation and enrichment of cooperation between the National People’s Congress of China and the Parliament of Tajikistan.

　　three

　　The two sides noted with satisfaction that great achievements have been made in building the "Belt and Road" over the past 10 years, and this initiative has become a popular platform for international public goods and international cooperation. The two sides support further strengthening the joint construction of the "Belt and Road Initiative" and Tajikistan’s "National Development Strategy by 2030", and unanimously agree to fully implement the consensus and agreement reached in the field of pragmatic cooperation between the two countries.

　　Tajikistan supports global development initiatives, highly appreciates China’s help for Tajikistan’s economic and social development and improvement of people’s livelihood, and is satisfied with the results of cooperation between the two sides. The two sides will continue to deepen pragmatic cooperation, promote development and accelerate the implementation of the UN 2030 Agenda for Sustainable Development.

　　The two sides will take measures to further expand the scale of bilateral trade, optimize the trade structure, deepen cooperation in the fields of service trade, e-commerce, digital economy and sustainable development, jointly safeguard the stability and security of the industrial chain supply chain, and explore new opportunities for trade and innovation cooperation between the two countries. The two sides spoke highly of the important role played by the China-Tajikistan Intergovernmental Economic and Trade Cooperation Committee.

　　The two sides will deepen cooperation in the fields of oil and gas, light industry, mining, chemistry and food industry, building materials production, electric power, key minerals, new energy, transportation infrastructure, communications, health and pharmacy, and strengthen project cooperation.

　　The two sides believe that the upgraded China-Tajikistan investment agreement will provide better institutional guarantee for investors from both sides, and are willing to further promote and protect two-way investment in accordance with the upgraded agreement.

　　The two sides positively evaluated the role played by the China-Tajikistan Investment Cooperation Working Group in deepening bilateral investment cooperation, and are willing to continue to explore and promote investment cooperation through this mechanism, improve the level of investment cooperation, promote the implementation of key projects, protect the rights and interests of investors, and create a fair and just investment environment.

　　The two sides decided to deepen cooperation in the field of "single window" of international trade, promote interconnection and electronic transmission of trade documents, and further enhance the level of cross-border trade facilitation.

　　The two sides will deepen scientific and technological exchanges, tap the potential of cooperation in basic research and applied research, and support the construction of joint laboratories and research centers in the fields of cloud computing, artificial intelligence, big data and nanotechnology.

　　The two sides believe that we should attach importance to the popularization of high-tech applications, encourage joint investment in the implementation of high-tech projects in the industrial field, and produce competitive high value-added products.

　　The two sides stressed that it is of great significance to continuously deepen cooperation in scientific and technological innovation, and will actively promote exchanges between young scientists and achieve pragmatic results in technology transfer, joint research, and joint construction of scientific research platforms.

　　Tajikistan welcomes the Global Artificial Intelligence Governance Initiative proposed by China and is willing to strengthen dialogue and cooperation in the fields of artificial intelligence development, security and governance.

　　The two sides believe that it is very important to deepen cooperation in the fields of traditional energy, renewable energy, green energy and the transformation of high-tech achievements and consolidate the legal foundation for the implementation of large-scale cooperation projects in the above fields.

　　The two sides are willing to implement common renewable energy projects, including cooperation in capacity, technology and standards in solar photovoltaic, energy storage batteries and other green energy fields.

　　The two sides reiterated that they will closely cooperate in the fields of green finance, green technology, smart agriculture, water-saving technology, prevention of desertification and soil degradation, and efficiently implement cooperation projects in the fields of digital economy and green development under the framework of jointly building the "Green Silk Road".

　　The two sides are willing to expand pragmatic cooperation between scientific and professional institutions, improve agricultural production efficiency in Tajikistan and ensure food security.

　　The two sides pointed out with satisfaction that the logistics cooperation between the two countries has achieved results, and stressed the importance of strengthening the interconnection of regional transportation infrastructure under the framework of the "One Belt, One Road" initiative, and are willing to continue to deepen the cooperation between China and Europe (Asia). Both sides attach importance to the construction of the China-Tajikistan-Afghanistan transportation corridor, gradually implement the modernization of the China-Tajikistan-Uzbekistan highway, give full play to the potential of the logistics center in curia, Tajikistan, and jointly build a "China-Tajikistan-Uzbekistan-Iran-Turkey" multimodal transport corridor.

　　The 20th anniversary of the opening of Calassou-Kuolemai Port, both sides expressed satisfaction with the operation of the port, and supported it to play an important role as a gateway of good-neighborliness and friendship between the two countries, further enhancing the efficiency of customs clearance throughout the year. The two sides agreed to speed up the modernization of the port and continuously improve the port capacity. Both sides are willing to implement the highway construction project from Varshez to Calassou-Kulemai Port in Gorno-Badakhshan Autonomous Prefecture of Tajikistan.

　　The two sides pointed out that cooperation should be further strengthened, the Agreement on Facilitation of International Road Transport among the Governments of the Shanghai Cooperation Organization (Dushanbe, 2014) should be fully implemented, and close cooperation should be made under the framework of the Shanghai Cooperation Organization Infrastructure Development Plan (Samarkand, 2022) to promote the implementation of transnational infrastructure projects.

　　four

　　Tajikistan supports China’s global civilization initiative and is willing to work with China to promote global civilization exchanges and mutual learning.

　　The two sides pointed out that people-to-people exchanges are of key significance to further enhancing mutual understanding between the two peoples, consolidating good-neighborly friendship from generation to generation and consolidating the social foundation of bilateral relations.

　　The two sides support further expansion of cooperation in the fields of health care and traditional medicine.

　　China is willing to assist Tajikistan in training medical experts and deepen bilateral and multilateral cooperation with Tajikistan in the fields of disease prevention and control and health emergency.

　　The two sides will vigorously promote the cooperation between friendship associations and other social friendly groups, enhance exchanges and promote the communication between the people.

　　The two sides support expanding cooperation between friendly provinces, prefectures and cities of the two countries and making full use of local cooperation to promote all-round cooperation between the two countries.

　　China welcomes Tajikistan to join the Asian Cultural Heritage Protection Alliance. Under the framework of the Alliance, the two sides will jointly carry out pragmatic cooperation in ancient civilization research, monument restoration and joint archaeology.

　　The two sides support deepening exchanges and mutual learning among civilizations and oppose attempts to "eliminate culture and tamper with history".

　　five

　　The two sides believe that efficient cooperation in the security field reflects the high level of mutual trust between the two countries. Tajikistan supports China’s global security initiative and is willing to carry out exchanges and cooperation with China to jointly safeguard regional and world peace and security.

　　The two sides support the security and border defense authorities to maintain close communication, strengthen information exchange on cracking down on "three forces", illegal drug trafficking and transnational organized crime, strengthen cooperation in border areas and prevent cross-border movement of terrorists, and exchange experiences on key infrastructure, large enterprises and strategic cooperation projects.

　　The two sides will cooperate on the establishment of a meeting mechanism between China and Central Asian Ministers of Public Security and Interior.

　　The two sides will take measures to strengthen cooperation in combating illegal immigration, human trafficking, money laundering and economic crimes.

　　The two sides are willing to deepen and expand cooperation in the fields of border defense technology and equipment, preventing illegal border crossing, and combating terrorism and transnational criminal gangs.

　　The two sides positively evaluated the work of the China-Tajikistan Joint Border Committee and instructed relevant departments to further strengthen the construction of this mechanism and consolidate the good momentum of China-Tajikistan border security, stability, prosperity and development.

　　The two sides positively evaluated the friendly and cooperative relations between the two armies, and will continue to deepen military mutual trust and strengthen pragmatic exchanges in the fields of group visits, personnel training and joint anti-terrorism exercises.

　　China attaches great importance to Dushanbe’s anti-terrorism and its financing agenda, and points out that it is of great significance to implement the strategy of the Republic of Tajikistan to combat extremism and terrorism for 2021-2025.

　　The two sides support deepening cooperation in the field of emergency response, carrying out pragmatic cooperation in the fields of preventing and responding to natural disasters, ensuring safe production, emergency rescue and ensuring emergency industrial products, and strengthening cooperation within the framework of multilateral mechanisms such as the United Nations, the Shanghai Cooperation Organization and the China-Central Asia mechanism.

　　The two sides will deepen cooperation in the judicial field and promote mutual visits and personnel training cooperation between representatives of procuratorates and other law enforcement agencies of the two countries.

　　six

　　The two sides reaffirmed that an independent, neutral, unified, inclusive and peaceful Afghanistan, far away from terrorism, war and drugs, and living in peace and harmony with all its neighbors, is in the common interest of the Afghan people and all countries in the region. The two sides support the establishment of an inclusive government in Afghanistan with the participation of representatives of all ethnic, religious and political groups.

　　Noting that the humanitarian situation in Afghanistan is still grim, the two sides support the international community to continue to provide necessary assistance to the Afghan people who have suffered from war and hardship.

　　The two sides reiterated their willingness to jointly take measures to prevent and respond to the risks and challenges faced by regional countries from Afghanistan and the region.

　　China has taken note of Tajikistan’s initiative to build a "safety belt around Afghanistan".

　　seven

　　The two sides pointed out that maintaining peace, stability and development in Central Asia is very important for countries in the region and even the world, and fully support the efforts of regional countries to ensure sustainable development and build a region of peace and common prosperity. The international community should fully respect the history and cultural traditions of Central Asia and make joint contributions to regional development and prosperity.

　　The two sides spoke highly of the implementation of the consensus reached at the first China-Central Asia Summit held in Xi ‘an on May 19, 2023, welcomed the establishment of the secretariat of the mechanism, believing that it would strengthen cooperation between China and Central Asian countries, and reiterated their efforts to ensure the success of the second China-Central Asia Summit held in Kazakhstan in 2025.

　　Both sides unanimously support strengthening the central role of the United Nations in international affairs, safeguarding the authority of international law, safeguarding world peace and stability and promoting international cooperation.

　　The two sides stated that they would abide by the Charter of the United Nations and the universally recognized basic principles and norms of international law in international affairs and bilateral relations.

　　The two sides spoke highly of and supported deepening mutual trust and carrying out all-round strategic cooperation in mechanisms such as the United Nations, the Shanghai Cooperation Organization and the Conference on Mutual Cooperation and Confidence Measures in Asia to jointly address global and regional challenges.

　　The two sides pointed out that the cooperation between China and Tajikistan in the Shanghai Cooperation Organization will help to further consolidate the status of the organization and promote mutually beneficial cooperation among member States. Tajikistan congratulates China on assuming the rotating presidency of the SCO from 2024 to 2025 and will fully support China.

　　China supports a series of initiatives on global water issues initiated by Tajikistan, especially the ten-year action of "Water for Sustainable Development" initiated by Tajikistan and the International Year of Glacier Protection in 2025, which will promote the harmonious development between man and nature and global sustainable development.

　　China spoke highly of the successful holding of the Third High-level Conference on Water for Sustainable Development for the Decade 2018-2028 in Dushanbe from June 10 to 13, 2024.

　　The two sides agreed to continue to maintain high-level active political dialogue on issues of common concern.

　　The Chairman of the Supreme Leader thanked President rakhmon and the people of Tajikistan for their warm and friendly reception and invited President rakhmon to pay a state visit to China at a convenient time. President rakhmon expressed his gratitude and accepted the invitation.

　　People’s Republic of China (PRC) Republic of Tajikistan

　　President president

　　Supreme Leader emomali rakhmon

　　Dushanbe, 5 July 2024

These four seasonal fruits in winter can nourish the lungs and spleen and stomach if eaten correctly.

It’s cold. Are you wondering if you can continue to eat fruit? In fact, it is impossible not to eat fruit at all.

But if you eat a little fruit, you may feel cold in your stomach, and cough and phlegm will increase.

This is actually because the cold and dampness in the body have increased!

Citrus fruits (such as oranges, pomelos and honey pomelos), apples and pears are suitable for winter fruits. These fruits have a certain warming effect on the cold climate in winter and are suitable for eating.

Eating fruit in winter follows three principles.

1. Eat in moderation

Fruits in winter are usually rich in water and sugar, so we should pay attention to the right amount when eating to avoid excessive intake of sugar. Especially for people with diabetes or poor blood sugar control, we should choose and eat fruits carefully.

2. Warm treatment

If you are worried that eating cold fruit will cause cold stomach or discomfort, you can choose to heat the fruit.

3. Eat with staple food

When eating fruit, it is best to eat it with some staple foods, such as rice and bread. This can balance the cold nature of fruits and reduce the stimulation to the digestive system.

These four fruits are recommended in winter to nourish the lungs and spleen and stomach.

1. Oranges-It is better to warm them up.

Oranges taste sweet and sour, but they are cold in nature. It can moisten lung, promote fluid production, regulate qi and regulate stomach.

Generally speaking, people suffering from cold cough and excessive phlegm are not suitable for eating oranges, but in fact they are not suitable for eating raw oranges. Everyone may have this experience. After eating a few sugar oranges or tangerines, there is not enough moist feeling in the mouth, but it will be a little sticky and thirsty, and phlegm will increase.

The main reason is that the orange itself is cold and cold, which will affect the digestive function of the spleen and stomach and slow digestion. In addition, oranges contain more sugar, which will lead to satiety and phlegm if it is not absorbed by the spleen and stomach in time.

There are two solutions, one is to eat less, and the other is to eat warm oranges.

You can boil oranges and eat them when they are hot.

The further method is to burn the red oranges. For cold cough, burning red oranges is very effective.

The outermost layer of orange peel, known as orange peel in Chinese medicine, is pungent and warm in nature and bitter in taste, which can regulate qi, relieve dryness and phlegm.

When the orange is roasted by fire, you can see that the outside of the orange is steaming. In fact, it is not only emitting outward, but also emitting inward. When it enters the orange meat, the orange meat has a pungent medicinal property.

2, Apple-the most peaceful

Apples are sweet and cool. It is the most peaceful fruit in autumn and winter.

Although apples are also cool fruits, most people can eat them. If you are worried, you can also eat ripe apples, cut them into pieces and boil water, or eat them directly after steaming, all of which are very delicious and healthy. Apple is very suitable for people who have a bad spleen and stomach and want to supplement body fluids.

Steamed apples also have the effect of relieving diarrhea.

3, pears-clearing heat and moistening the lungs

Pear is a common fruit in winter. It tastes crisp and juicy and is very popular with people. Pear is rich in nutrients such as vitamin C, cellulose and potassium, which can promote intestinal peristalsis and relieve constipation. Especially the stewed pear cup is a good food to warm the stomach and intestines. In addition, pears also have the effects of moistening the lungs, relieving cough, clearing away heat and quenching thirst, which has a certain effect on relieving symptoms of dry cough and thirst.

Recommended recipe: [stewed pear cup]

Prepare ingredients: pear, rock sugar and medlar.

The method is as follows: clean the pear, cut it 1 cm below the pear handle, use it as a cover, remove the core with a spoon, make a pear cup, add a proper amount of crystal sugar and Lycium barbarum, and steam it in a steamer for 15-20 minutes. This stewed pear cup is not only delicious, but also has a good effect on moistening lung and nourishing stomach.

4, horseshoe-shengjin Runyin, cooked to eat

Horseshoe, also called water chestnut. Sweet taste, cold nature. It has the effects of promoting fluid production, clearing away heat, resolving phlegm and resolving food stagnation, and is mainly used for treating febrile diseases such as thirst, sore throat, phlegm-heat cough, etc. It is most suitable for people with yin deficiency and fire flourishing.

Horseshoe itself grows in the ground, and it is a wetland paddy field, and winter is its maturity. This kind of fruits and vegetables are often cold.

Raw horseshoes carry ginger worms and are not suitable for raw food. After cooking, the cold nature will be neutralized, and it is more convenient to eat and peel. Can be boiled with sugar cane, which has the effect of clearing phlegm.

In short, when eating fruit in winter, we need to pay attention to proper amount, warm treatment and collocation of staple food to keep our health and comfort.

Warm reminder: If you have special health conditions or diseases, it is recommended to consult a doctor or dietitian.

Read the original text

Play the villain and then the policeman! After Under the Sun, Peng Guanying took on a new play. Do you think it will be a play？

In Under the Sun, Feng Xiaosheng finally won a short victory, forcing Liang Yuze to go abroad and live a self-righteous and beautiful life with Ke Ying. Even, Ke Ying invited Feng Xiaosheng to have dinner together, and their relationship made progress in stages.

Ke Ying fed Feng Xiaosheng steak, and then withdrew it when he was about to get into the mouth. Feng Xiaosheng forcibly took her arm and ate the steak. The expression of the two people’s confrontation exposed the man’s possessiveness completely.

This flowing expressive force is attributed to the actor’s acting skills: I just saw A Ying’s surprise when she was feeding, and the meat was slowly handed to her mouth to show a spoiled smile. Ke Ying took back her hand and suddenly froze, and then she was fierce and overbearing when she grabbed her hand and ate it. There was nothing wrong with Peng Guanying. Taking this drama is undoubtedly the most correct choice he has made.

"Under the Sun" has aroused a thousand waves since it first announced that the novel was made into a film and television. For no other reason, the original novel "Things in the Palm" describes that the university lecturer He Yan still tries to get rid of the clutches after being imprisoned by the male host Fu Shenxing. In order to highlight the tense relationship between men and women, there are many explicit and cruel pictures. However, it is definitely impossible to film and television all the contents, so everyone’s attitude towards TV dramas is both tense and contradictory.

Sure enough, after the TV series was broadcast, a lot of content was added and deleted in order to be more practical, and even the male master was changed into a male two. But what hasn’t changed is that the role played by Peng Guanying is still an object of resentment.

But Peng Guanying’s acting didn’t disappoint everyone. Whether it is Shen Shijie’s diabolical cruelty in the early stage or the cruel cunning of Feng Xiao’s voice in the later stage, Peng Guanying interprets it perfectly and impeccably.

Theoretically speaking, Peng Guanying is a newcomer to film and television, but unfortunately he is a newcomer of great age.

Before, everyone could only think of Princess Lanling, which co-starred with Baby Zhang a few years ago. Although his acting skills were also praised in the play, there was no follow-up resources, and he seemed to disappear from the audience’s field of vision soon.

After that, when I think of him, I can only remember that he and Zhu Yilong, who have exploded in recent years, are close friends, and Peng Meimei and Zhu Meili are active in each other’s social platforms.

However, with the online drama "The Soul of the Town", Zhu Yilong made numerous rounds, followed by other works, and soon gained a firm foothold. And "Peng Beauty" is still an invisible man.

In 2020, Zhu Yilong and Liu Shishi’s new drama "Dear Yourself" landed in iQiyi, in which Peng Guanying played love rat, who betrayed his wife. After a long time, Peng Guanying’s acting remained at a certain level, and playing against Adi often made people hate it. I wish he would disappear immediately.

Later, when he lost his way and asked his wife to forgive him, his eyes were tearful, and the audience shouted, so pitiful that I even wanted to forgive him.

Peng Guanying finally became famous.

With the update of "Under the Sun" episode by episode, Feng Xiaosheng’s temperament is also slowly changing, from revenge on Ke Ying at the beginning to hopelessly falling in love with her later, all of which are manifested in the actor’s smiles, which also tests the actor’s acting skills.

But Peng Guanying has performed well from the beginning, and he is bound to play the role well from beginning to end.

Years ago, Peng Guanying’s new play "Backlight Man" started, with Zhang Yujian as his partner, both of whom played the role of police.

The online drama "Backlight" is adapted from the novel "In the Dark" by writer Jin Shichai, which mainly tells the story of undercover policeman Xie Lanshan and portrait expert Shen Liufei fighting criminals together.

Xie Lanshan, played by Peng Guanying, and Shen Liufei, played by Zhang Yujian, met at the police academy. They established a strong affection and vowed to become excellent anti-drug policemen.

Among the posters issued at present, this group of quasi-anti-drug policemen are determined, and they are willing to hide in the dark to protect the light.

Perhaps the audience is still immersed in the vicious villain in Under the Sun, but Peng Guanying has turned over and become a policeman. With his acting skills, he is bound to perform a completely different image from Feng Xiaosheng and look forward to his new works. Wen/Hua Su

McKinsey： It is estimated that generative artificial intelligence can increase the global economy by 4.4 trillion US dollars.

When it comes to the ability to generate, arrange and analyze content, generative artificial intelligence is a game changer, which has the potential to change society and economy.

As an open technology-it doesn’t only exist in remote laboratories or technical communities in Silicon Valley-generative artificial intelligence lowers the threshold for participation. In the era of generative artificial intelligence, anyone can be a creator. But it also needs a thorough labor transfer, changing the production process in the economy, and then changing the types of tasks undertaken and the skills needed for success.

(Source: AI generation)

Not long ago, Microsoft entrusted Access Partnership, a global technology consulting company, with the Analytics Association of the Philippines, FICCI, The Federation of Indian Chambers of Commerce & Industry cooperates with local partners in many countries, such as GLOCOM (Center for Global Communications), to conduct national-level research on the potential economic impact of generative artificial intelligence in Asia.

The study estimates that productivity in India, Japan and the Philippines alone may increase by $621 billion, $1.1 trillion and $79.3 billion, and studies in Malaysia, Indonesia and South Korea are under way. The research results of these countries are consistent with other global studies. For example, a recent report by McKinsey estimated that generative artificial intelligence could add $4.4 trillion to the global economy every year.

The potential economic growth is so great because generative artificial intelligence has an impact on most types of work: its impact can be considered as comparable to that of digitalization, not limited to the impact of specific products. In particular, this huge productivity improvement will come from three channels-the potential of generative artificial intelligence to release creativity, accelerate discovery and improve efficiency.

Although we can’t predict the future, generative artificial intelligence is likely to act as a "copilot" and enhance people’s ability to perform their duties, thus leading the evolution of role tasks, rather than completely eliminating work. For example, the research project of Access Partnership shows that 45% of workers in India may use generative artificial intelligence in 20% of routine work activities.

So, what is the potential impact on industry, employment and skills?

Unleash creativity

You can think of it as a digital update of the Renaissance. Given that generative artificial intelligence can provide various forms of output-text, images, video, audio, computer code and synthetic data-Asia is likely to see the explosive growth of new content. Ahmed Mazhari, president of Microsoft Asia, said: "Although innovation will continue to require the spark of human wisdom, generative artificial intelligence can play a role in supporting the innovation process."

By learning from a large amount of input data, generative artificial intelligence can help create new content, or just reduce the time and cost required for conceptualization. This technology is likely to open up new possibilities and use cases in the fields of news, academics, creative arts, marketing and product design, from journalists seeking to quickly collect story ideas to brand strategists looking for brainstorming concepts, and then to researchers who want to obtain manuscripts and modify and customize them on this basis.

Artificial intelligence has been widely used in many industries. For example, Coca-Cola has announced the use of generative artificial intelligence to create personalized advertising copy on a large scale, while Deloitte has found that the code development speed has increased by 20%.

Generative artificial intelligence will also accelerate the odd-job economy and individual entrepreneurship. For example, in India, the number of individual creators has been on the rise. A survey of more than 1,600 freelancers found that 47% people often use generative artificial intelligence tools, and more than 50% people said it had a positive impact on their productivity.

At the same time, as the Philippines strives to become a leading creative economy in Asia by 2030, generative artificial intelligence can play a key role in professionalizing the work of freelancers in the country.

Accelerate discovery

The second way that generative artificial intelligence can have a significant economic impact is to accelerate the process of scientific and educational discovery. This may include reducing research costs. For example, the query ability of this technology on a large number of data sets can help to develop and test hypotheses faster and more economically. This can also shorten the time needed to design new drugs from several years to several weeks.

According to the analysis of Access Partnership, the tasks of biochemists, biophysicists, astronomers, biologists, bioinformaticians and computer and information research scientists may be changed by generative artificial intelligence.

Another economic benefit is the role of generative artificial intelligence in improving educational achievements. For example, the Japanese government recently announced plans to allow students from primary school to high school to use generative artificial intelligence in a limited way to promote classroom discussions and artistic activities. In 2022, India launched the AIoT project to upgrade the curriculum of 50 schools.

This technology can also simplify lesson preparation and curriculum planning, so that teachers can create personalized learning experience according to the algorithm analysis of students’ learning patterns and preferences.

According to Access Partnership, the application of this kind of generative artificial intelligence will lead teachers in the fields of biological science, nursing, physics, geography, architecture and computer science to rearrange the priorities of teaching activities.

In Asia, the business process outsourcing industry, which is vital to many economies, is facing a great opportunity to seize the potential efficiency improvement first.

From automated workflow to real-time multilingual customer support, Mazari believes that "the possibility of using generative artificial intelligence may become an important competitive advantage in view of the possible intensification of competition in global market share." For example, he suggested that in the Philippines, the medical industry can re-focus on professional fields such as medical record preparation, as well as knowledge-based processes such as software development and market research.

What’s next?

Although generative artificial intelligence has brought opportunities to all Asian economies, this transformation must also be treated with caution. Pioneers can play a key role in formulating policies and regulations and encouraging innovation, investment and responsible use of the environment.

Accountability must become a core principle to ensure that machines are always effectively supervised by people. Therefore, with the growth of generative artificial intelligence, more organizations will need staff to supervise the reliable, fair and ethical use of this technology. Mazari explained: "Technology still needs human judgment to explain the potential algorithm deviation and the interaction between people to manage important stakeholder relationships."

Throughout history, technological progress will bring new employment opportunities and long-term economic growth, including the development of unimaginable roles today. Throughout Asia, the primary goal should be to ensure that these opportunities are fairly distributed, while increasing investment to ensure that the workforce is fully prepared.

In order to flourish in the world of generative artificial intelligence, people will have to apply this technology in a series of situations and tasks. In India and the Philippines, important initiatives are being carried out to improve the digital literacy of the whole people.

However, the cooperative method of government, industry and educational institutions is very important. Mazari said: "Today, there are skills training programs all over Asia, but because of race, gender, geographical location or other obstacles, too many people can’t get services at all." 61% students in ASEAN countries have not received any digital literacy education at school. This means that action must be taken quickly now to ensure that this technology will have an economic impact in the future.

Support: Ren

Reporting/feedback

The first domestic CAR

Economic Observer Network reporter Qu Yixian After a long period of downturn, China’s innovative medicine industry has received a shot in the arm. On March 1st, 2022, CAR-T therapy of legendary creatures was officially approved by the US Food and Drug Administration (FDA) for the treatment of patients with relapsed/refractory multiple myeloma (r/r MM). This is the first domestic CAR-T cell therapy approved by FDA.

The approved CAR-T therapy is called Cilta-cel, which targets BCMA and is the second CAR-T therapy targeting BCMA in the American market. On the topic of domestic innovative drug "going out to sea", it is a sample-as early as 2017, it signed a global exclusive license and cooperation agreement with Johnson＆Johnson to jointly develop and commercialize this product.

Huang Ying, CEO and CFO of Legendary Bio, revealed that the price of Cedarchiorense in the United States is $465,000. This pricing strategy is because the pricing range of several CAR-T products that have been listed in the American market is $400,000-$470,000, and the price of the first CAR-T product with the same target is $419,500. "The premium of about 11% is a very reasonable premium, based on our differences in clinical efficacy."

According to the agreement signed at that time, in Greater China, Johnson & Johnson and Legend Bio will share the costs and benefits in a ratio of 3: 7; In other parts of the world, the agreed ratio is 5: 5.

Huang Ying said that in response to the commercialization of Cedakio Orense in the United States, Legendary Biology has recruited its own sales team in the past 6-9 months, responsible for 75-80% of large hospitals and clinics in the United States; Johnson & Johnson has a relatively large tumor sales team serving the community, and will recommend Cedactylosin to 5,500 hematology oncology specialists in the United States, hoping that these specialists can introduce patients to large local diagnosis and treatment centers and hospitals for treatment with Cedactylosin. At the same time, Johnson & Johnson will also set up a relatively small and specialized product team to promote this product to large hospitals and diagnosis and treatment centers.

Behind the first CAR-T

Sida Chiolense has attracted much attention in the research and development stage.

ASCO, the American Society of Clinical Oncology, is a great event in the medical field every year, and many heavy new drugs choose to publish the latest research data on ASCO. On the last day of ASCO in 2017, the legendary creature announced the early data of the self-developed CAR-T product LCAR-B38M (R&D code of Sida Giorense) to the pharmaceutical industry peers and experts around the world.

According to the report of Zhao Wanhong, the research organizer and deputy director of the Department of Hematology, the Second Affiliated Hospital of Xi ‘an Jiaotong University, among the 35 patients with recurrent multiple myeloma who were treated by CART, 33 (94%) got clinical remission 2 months after treatment, and the objective remission rate was 100%.

In addition, among the 19 patients who received treatment at the earliest time, 14 patients achieved strict complete remission, 1 patient achieved partial remission, and 4 patients achieved excellent partial remission. The earliest patients who received treatment have lived for more than one year, and they have reached the living state of healthy people.

It’s not imitation, nor improvement, but the exploration and innovation of a China enterprise in the "no man’s land", so when the data of Xidajiaolun match came out, everyone was surprised.

Fan Xiaohu, chief scientific officer of Legendary Biology, recalled that at that time, "it attracted global attention and (Legendary Biology) became the dark horse of China", and many people in the industry gave him feedback, and many start-ups after 2017 were encouraged.

Followed by a number of international pharmaceutical companies seeking business cooperation, after repeated communication and back tone, Legend finally joined hands with Johnson & Johnson.

In December, 2017, Legendary Bio signed an exclusive global license and cooperation agreement with Johnson & Johnson to jointly develop and commercialize Cedarchiorense. Johnson & Johnson paid Legendary Bio a down payment of $350 million and subsequent milestone payments.

By today’s standards, the down payment of $350 million is not high, but at that time, it was the best condition for China pharmaceutical companies to record the largest amount of down payment for foreign patent authorization and cooperation.

Regarding the cooperation between the two parties, Huang Ying said that Legend’s cooperation with Johnson & Johnson has strengthened the legendary creature’s ability in the process of R&D and registration of Sida Chiolense. From early R&D to late R&D, including clinical, commercial production, GMP production, compliance registration and other processes, the legendary creature’s team actively participated in the whole process, and also cultivated their own ability in the process of learning from Johnson & Johnson.

However, this cooperation model also has shortcomings, "the whole cycle is very long and the investment is very, very large", because Legend’s investment in the American market is as 50-50 as Johnson & Johnson’s, which is a relatively large financial burden for legendary creatures of innovative pharmaceutical companies.

multiple myeloma

Cedactylorense is a chimeric antigen receptor (CAR) T-cell immunotherapy with two single-domain antibodies targeting B-cell mature antigen (BCMA), which is administered by one-time infusion.

Cedactylorense has been approved by FDA to treat patients with relapsed or refractory multiple myeloma, who have received four or more treatments in the past, including proteasome inhibitors, immunomodulators and anti-CD38 monoclonal antibodies.

Multiple myeloma is considered as an incurable hematological tumor, and it is a malignant disease caused by excessive proliferation of plasma cells in bone marrow. Most patients relapse after initial treatment, and the prognosis is not good after receiving the main drugs such as immunomodulator, proteasome inhibitor and anti-CD38 antibody.

According to the American Cancer Society, in 2022, more than 34,000 people in the United States will be diagnosed with multiple myeloma, and more than 12,000 people will die.

Sundar Jagannath, a professor of hematology oncology at Mount Sinai Medical College and a principal investigator of CARTITUTE-1, said that the treatment process of most patients with multiple myeloma is a cycle of continuous remission and recurrence, and only a few patients get deep remission after last-line treatment. "That’s why I am very excited about the results of CARTITUDE-1 study, which shows that Sidakiorense can provide deep and lasting remission and long-term no treatment even after multi-line treatment.

The approval of Sida Chiolense is not based on the data reported in ASCO in the United States in 2017, but on the key data of a CARTITUDE-1 study. CARTITUDE-1 is an ongoing phase 1b/2, open-label, one-arm, multi-center study, with 100% patients from the United States.

In CARTITUDE-1 study, 97 patients with R/R MM experienced deep and lasting remission, with an overall remission rate (ORR) of 98% and a strict complete response (sCR) of 78%. During the median follow-up of 18 months, the median remission duration (DOR) was 21.8 months.

The incidence of multiple myeloma in China is 2-3 patients per 100,000 people. Although it is lower than that of Caucasian and African people, there are considerable unmet clinical needs because of its large base.

Regarding the listing of this product in China, according to the latest communication between Legend Bio and National Medical Products Administration Drug Evaluation Center (CDE), some patients need to be re-enrolled in clinical trials. Huang Ying said that she would keep in touch with CDE during this period.

Enlightenment of "going out to sea"

The research and development cost of innovative drugs is extremely high, and with the implementation of policies such as domestic centralized procurement and medical insurance negotiation, it is almost impossible to recover the research and development cost in a short period of time after the innovative drugs are listed. Under the circumstance that the cost cannot be covered by a single market, it has become an industry consensus to "go out to sea" and develop the international market.

Compared with biopharmaceuticals, the R&D and production of CAR-T are more complicated. The "Going to Sea" of Sidaji Orense is another innovative drug listed in the United States after Zebutini of Baekje Shenzhou.

But before that, in February, Cinda Bio’s PD-1 product Cindilizumab had just been defeated in the United States. In view of the passing of cindilizumab, FDA experts mainly pay attention to three issues: first, whether the control group selected in clinical trials is reasonable; Second, the clinical trial is only done in China population, is it applicable to American patients? Thirdly, it mainly studies whether the design of the terminal is reasonable.

In Huang Ying’s view, since China joined ICH, the regulatory standards of National Medical Products Administration, China are basically the same as those of FDA, focusing on efficacy and product safety evaluation. "There is not much difference between FDA and CDE standards. There may be slight differences in the number of patients enrolled, the length of follow-up, GMP, production process, quality control and other issues, but for a new drug, efficacy and safety are the gold standards."

However, Huang Ying also believes that for enterprises, there are also places that need special attention, such as whether the experimental population can represent the situation of American patients in the real world when doing clinical trials. In the United States, the Asian population is about 5%. It is difficult to apply for approval with the data of 100% Asian population or Chinese.

One more thing, does the control group designed in clinical trials use placebo or the best treatment standard already available in the market? "CDE has also issued guidelines. Even if you do clinical trials in China in the future, you can’t just use placebos, but you need to use the best standard drugs in the industry as the control standard." Huang Ying said.

Fan Xiaohu, on the other hand, thinks that biomedical enterprises in China should not worry about policy vacillation and payment all day long, or whether the door of the FDA in the United States will be closed. "These don’t need to be overly worried and interpreted, but (what is needed) do their own thing well and do scientific and technological innovation well."

Reporting/feedback

Is AI big model universal or special？ Here comes the expert opinion.

With the continuous popularity of the concept of ChatGPT, the integration process of AI technology and thousands of industries has accelerated, and more diverse and complex application scenarios have emerged, which has put forward higher requirements for computing services. At the recent 2023 China Computing Power Development Seminar, many authoritative experts and scholars in the industry conducted in-depth exchanges and discussions on the opportunities and challenges of computing power under ChatGPT from the perspectives of technology and ecology, determined the development trend of the liquidation power industry, and gave countermeasures on the current artificial intelligence infrastructure and computing power service construction.

The key to the construction of computing power infrastructure lies in the combination of general and specialized courses.

As an important engine of computing power supply, artificial intelligence computing power infrastructure has ushered in a "big test" in terms of construction layout. According to incomplete statistics, more than 30 cities in China are building or proposing to build intelligent computing centers, which basically adopt the mode of "government-led, enterprise-contracted and joint operation". That is, it will be funded by local finance in a unified way, and will provide public computing services for all walks of life after completion. In this mode, the intelligent computing center is located in public service facilities. First, it must meet a wide range of application scenarios, be universal and realize universality. Secondly, it should also be able to support some personalized application scenarios that require high calculation accuracy and efficiency, and be efficient and dedicated.

Many experts at the meeting pointed out that the combination of "general specialization" will become the key to the construction of artificial intelligence computing infrastructure. Zhang Yunquan, a researcher at the Institute of Computing, Chinese Academy of Sciences, said that the emergence of ChatGPT realized the emergence of cognitive intelligence for the first time. At the same time, it also made the computing industry face new challenges such as rising demand, diversified development, prominent energy consumption problems and high use threshold. Computational power integration, factor coordination and ecological cooperation are the keys to the development of artificial intelligence computing infrastructure in the changing situation.

The most important thing for scientific computing is to improve its credibility, and so is artificial intelligence. Yuan Guoxing, a researcher at Beijing Institute of Applied Physics and Computational Mathematics, pointed out that to make the model more credible, it is necessary to continuously improve the accuracy of the model. Now, in order to improve the accuracy, the model is getting bigger and more complex, and the data increment is getting bigger and bigger. However, beyond a certain range, the cost of building a general model is too high, which requires a special model to solve the problem, so we should study this problem by classification.

Chen Runsheng, an academician of China Academy of Sciences, suggested that using large-scale academic infrastructure to build professional models can not only achieve high accuracy but also achieve low energy consumption. He believes that artificial intelligence computing services should have a layout and a division of labor. Don’t rush into it, don’t give up halfway, and avoid wasting resources.

Qian Yupei, an academician of the China Academy of Sciences, said that the question of generality or speciality has not only appeared in the field of large models, but has actually existed since the beginning of calculation. Heterogeneity is a trend, and different things should be done with different efficient tools. However, in the modern industrialized system, we should consider the cost, the performance is high and the energy consumption is low, but the design cost and manufacturing cost are too high. To compromise, we should not only achieve high performance and low operating cost, but also have low design cost and manufacturing cost, so that the whole system cost is low. With the tolerance of design cost and manufacturing cost, we should support different calculations with more efficient heterogeneous structures and components as much as possible.

Liao Xiangke, an academician of China Academy of Engineering, believes that the general model can serve all walks of life, and we need a general big model that can benchmark ChatGPT, and all walks of life can fine-tune and reason on the basis of the general big model according to the actual needs of the industry, and customize the special model of the industry.

Experts believe that on the one hand, the artificial intelligence computing infrastructure should have full-precision computing power and become a "generalist" of computing power, so that users can allocate computing resources according to practical application scenarios such as AI for Science and AI for industries, including general computing power, special computing power and even high-performance computing power to support their own business development. On the other hand, the artificial intelligence computing infrastructure of "combination of general and specialized" is a comprehensive scheme, which tests the openness of the underlying architecture. It is necessary not only for different technical routes to blossom, but also for adaptation and compatibility to achieve the same goal, so as to form an all-inclusive overall architecture, which will lower the threshold of application migration and promote the development of industrial ecology.

Computing network should connect resources and ecology.

The development of computing power network has also become a topic of great concern at present. The big model craze has brought huge demand for computing power, which has led to the uneven distribution of computing power between industries and regions. For the construction of computing power network, it is only the initial stage to unify the management and scheduling of various types of computing centers all over the country and realize the integration of computing power, storage, network and data. The more important construction link lies in the deep connection of the whole industrial ecology, that is, connecting people, connecting applications and services.

Zheng Weimin, an academician of China Academy of Engineering, said frankly: "Many institutions and enterprises in China are making big models, and each participant needs a lot of computing power support, which may cause a waste of computing power resources, which can be combined to form a big computing power, share it as a model, and make this model a new infrastructure. But there are still many problems to be solved to achieve this goal, such as how to connect different models, how to realize transmission, and how to meet the requirements for computing power.

"In terms of computing power interconnection, China currently has different schemes such as intelligent computing network and super-computing interconnection. Among them, the supercomputing Internet is to operate the supercomputing center with the thinking of the Internet, and connect the capabilities and resources of computing power supply, application development, operational services, users and other parties in the industrial ecology to build an integrated supercomputing network and service platform. In the tide of computing network construction, which road China will take in the end, how to connect our country’s computing resources, make good use of them, play a role and lower its threshold are all topics that need our discussion. " Zhang Yunquan said.

Supercomputing Internet, as an important form of computing power network, explains the essence of computing power network construction from the practical level. The first is the narrow sense of interconnection, that is, at the physical level, connecting computing centers of different architectures, building an infrastructure that can be used uniformly and serve the outside world, and realizing the scheduling and sharing of resources. Secondly, it is interconnected in a broad sense, that is, at the ecological level, the supercomputing center is operated with the thinking of the Internet, and based on the deep integration of resources such as computing, software and application solutions, an innovative platform led by application services is established, and the upstream and downstream are closely linked through the market-oriented operation and service system, so that the supply and demand sides can quickly connect and quickly find the resources they need.

"From the perspective of supercomputing the Internet, we hope not only to connect machines, but also to connect people, equipment and applications. The core is to be a supercomputing platform, and to make supercomputing and intelligent computing easy to use." Cao Zhennan, deputy director of the National High Performance Computer Engineering Technology Research Center, said.

Through the dual interconnection of physical and ecological aspects, computing network can further enable computing services, rationally allocate, integrate and release computing power, and lower the application threshold. Let computing power resources change from unattainable technology to universal and inclusive services, and support the development of major national scientific research projects, people’s livelihood and thousands of industries.

Cao Zhennan believes that there are still many bottlenecks and problems in the service process, whether it is super-calculation or intelligent calculation, and the most difficult one is the application problem. He suggested strengthening the coordinated development of software and hardware and attaching importance to the ecological construction of computing network.

Shan Zhiguang, director of the Information and Industry Development Department of the National Information Center, said that at present, algorithms and models are the places where there will be opportunities to make efforts in the future. ChatGPT is driven by centralized computing power. In the future, we may be able to take a different route, such as taking the next generation distributed route, and we can better connect some domestic computing infrastructures through more advanced interconnection technologies to tap stronger computing power.

"We still have to make a basic discussion from the evolution law of basic computing mode and the development law of artificial intelligence, so as to avoid rushing headlong into the crowd or following the trend at the phenomenal level, otherwise we can only run behind others forever. We must know that the computer field is competing for generations, and it is chasing further and further." Shan Zhiguang said.

"I think the concept of universality is changing." Tran van quang, a professor at Tsinghua University, said that the proportion of artificial intelligence computing forms in the whole data center will increase. However, at this stage, the AI Computing Center is still in a very early stage of development, and multi-party exploration should be encouraged at this stage.

Lu Zhonghua, a researcher in computer network information center, said that with the development of AI, the demand for computing power of AI services is increasing, and the trend is unstoppable. We should meet this trend. How to meet everyone’s increasing demand for computing power? In 5-8 years, we should try our best to make good use of the supercomputing center and intelligent computing center that have been built, so as not to waste the center resources that have been put into construction. We can take the lead in trying to develop large-scale model applications in some fields and encourage ecological construction. In addition, to build an artificial intelligence infrastructure system, we should not overemphasize the integrated layout, or we should support a hundred flowers under the guidance of national policies and hand over the rest to the market.

The Secretary-General of China Intelligent Computing Industry Alliance said quietly that the era of new computing power has arrived, and computing power will be the new kinetic energy and engine that will drive the digital economy forward in the future. At the same time, computing power is becoming a key factor affecting the country’s comprehensive governance and international discourse power. The core competitiveness of countries is focusing on computing power represented by computing speed, computing methods, communication ability and storage capacity. Whoever can master advanced computing power in the future will be able to grasp the initiative of development.

Author Song Jing
Editor Liu Jing
Mei bian ma Li ya
Producer Lian Xiaodong
Reporting/feedback

[Vernacular People’s Livelihood] In response to the Japanese nuclear pollution water discharged into the sea, China’s multi-sectoral institutions took action

　　CCTV News:The third week of August (August 19th — August 25), various departments voiced their voices and a series of policies were released one after another. The editor sorts out the important measures focusing on people’s livelihood concerns in many fields, which are closely related to your life and mine? Understand in one article.

　　◆　Consumption:General Administration of Customs completely suspended the import of Japanese aquatic products.

　　On August 24th, the Japanese government officially started the Fukushima nuclear sewage discharge project. In order to prevent the risk of radioactive pollution on food safety caused by the discharge of nuclear contaminated water from Fukushima, Japan, and protect the health of consumers in China, the General Administration of Customs decided to completely suspend the import of aquatic products (including edible aquatic animals) originating in Japan from that day (inclusive).

　　◆　Supervision:The General Administration of Market Supervision strengthened the supervision of aquatic product food safety and salt price.

　　In response to Japan’s nuclear pollution discharged into the sea, the General Administration of Market Supervision has further strengthened food safety supervision, prohibited food producers and operators from purchasing, using aquatic products and processed foods originating in Japan, making meals or selling them, strengthened food safety sampling and monitoring of imported aquatic products sold in the market, and investigated and dealt with illegal acts in strict accordance with the law.

　　At the same time, the General Administration of Market Supervision has deployed all localities to strengthen the monitoring of salt prices, and strictly investigate illegal activities such as hoarding, fabricating and spreading price increase information, etc.

　　◆　Monitoring:The Ministry of Agriculture and Rural Affairs has stepped up the monitoring of nuclear pollution risks of marine aquatic products.

　　In response to Japan’s nuclear polluted water discharged into the sea, the relevant person in charge of the Ministry of Agriculture and Rural Affairs said that it will strictly follow the national standard for the restricted concentration of radioactive substances in aquatic products, increase the monitoring of nuclear pollution risks of marine aquatic products, and ensure the quality and safety of aquatic products. At the same time, pay close attention to the possible harm to China’s marine fisheries caused by the discharge of nuclear pollution water from Fukushima, Japan, and protect the healthy development of marine fisheries.

当地时间2023年8月25日，日本东京，人们聚集在日本首相办公室前，抗议从受损的福岛核电站排放经处理的核污染水。

当地时间2023年8月25日，日本东京，人们聚集在日本首相办公室前，抗议从受损的福岛核电站排放经处理的核污染水。

　　◆　Life:China National Salt Group stated that 87% of the salt in China is well salt, and the reserves are sufficient.

　　Affected by the news that the nuclear polluted water from the Fukushima Daiichi nuclear power plant was discharged into the sea, there was a phenomenon of grabbing salt in Beijing, Shanghai and other places. China National Salt Group issued a statement on ensuring the supply of salt market, saying that at present, China’s salt product structure accounts for 87% of well salt, 10% of sea salt and 3% of lake salt, and the production of well salt and lake salt is not affected by nuclear pollution in Japan.

　　◆　健康：Can eating iodized salt prevent nuclear radiation? Beijing CDC rumors

　　After Japan’s nuclear sewage was discharged into the sea, there were rumors that "iodized salt can prevent nuclear radiation". Beijing CDC clearly pointed out that this view is incorrect. The purpose of iodizing salt is to prevent and treat iodine deficiency disorders. In a nuclear pollution accident, radioactive iodine is mainly accumulated in the thyroid gland. In the early stage of the accident, it is necessary to take 100mg of "stable iodine" once, which is equivalent to taking 3-5kg of edible iodized salt once.

　　The Dietary Guidelines for China Residents (2022) clearly states that "adults should not consume more than 5g of salt every day". If excessive intake occurs, it will cause serious burden to various organs of the human body, induce or aggravate cardiovascular and cerebrovascular diseases and chronic nephropathy, and even cause dehydration and even death in severe cases.

　　◆　Travel:The price pressure line is raised, and the price of refined oil products is "five consecutive rises"

　　国家发展改革委消息，根据近期国际市场油价变化情况，自2023年8月23日24时起，国内汽、柴油价格每吨均提高55元。

　　今年6月份以来，国内成品油最高零售限价历经连续五次上涨。据测算，家用轿车、小型私家车加满一箱92号汽油将较之前多花2-3元。

　　◆　健康：新冠病毒变异株EG.5出现，国家疾控局回应热点关切

　　世界卫生组织宣布，将新冠病毒变异株EG.5列为“需要留意的”变异株。加之身边感冒的人增多，民间出现对“三阳”的讨论，国家疾控局对此回应称，全球风险等级为低风险，该毒株虽在国内有流行趋势，不过已建立的奥密克戎XBB系列变异株人群免疫力对EG.5变异株仍具免疫保护作用，短期内不会发生规模性疫情。

　　◆　住房：换房退税优惠政策延续至2025年

　　8月25日财政部等3部门联合发布公告，决定自2024年1月1日至2025年12月31日，对出售自有住房并在现住房出售后1年内在市场重新购买住房的纳税人，对其出售现住房已缴纳的个人所得税予以退税优惠。