标签： 2021上海spa店推荐

The first domestic CAR

Economic Observer Network reporter Qu Yixian After a long period of downturn, China’s innovative medicine industry has received a shot in the arm. On March 1st, 2022, CAR-T therapy of legendary creatures was officially approved by the US Food and Drug Administration (FDA) for the treatment of patients with relapsed/refractory multiple myeloma (r/r MM). This is the first domestic CAR-T cell therapy approved by FDA.

The approved CAR-T therapy is called Cilta-cel, which targets BCMA and is the second CAR-T therapy targeting BCMA in the American market. On the topic of domestic innovative drug "going out to sea", it is a sample-as early as 2017, it signed a global exclusive license and cooperation agreement with Johnson＆Johnson to jointly develop and commercialize this product.

Huang Ying, CEO and CFO of Legendary Bio, revealed that the price of Cedarchiorense in the United States is $465,000. This pricing strategy is because the pricing range of several CAR-T products that have been listed in the American market is $400,000-$470,000, and the price of the first CAR-T product with the same target is $419,500. "The premium of about 11% is a very reasonable premium, based on our differences in clinical efficacy."

According to the agreement signed at that time, in Greater China, Johnson & Johnson and Legend Bio will share the costs and benefits in a ratio of 3: 7; In other parts of the world, the agreed ratio is 5: 5.

Huang Ying said that in response to the commercialization of Cedakio Orense in the United States, Legendary Biology has recruited its own sales team in the past 6-9 months, responsible for 75-80% of large hospitals and clinics in the United States; Johnson & Johnson has a relatively large tumor sales team serving the community, and will recommend Cedactylosin to 5,500 hematology oncology specialists in the United States, hoping that these specialists can introduce patients to large local diagnosis and treatment centers and hospitals for treatment with Cedactylosin. At the same time, Johnson & Johnson will also set up a relatively small and specialized product team to promote this product to large hospitals and diagnosis and treatment centers.

Behind the first CAR-T

Sida Chiolense has attracted much attention in the research and development stage.

ASCO, the American Society of Clinical Oncology, is a great event in the medical field every year, and many heavy new drugs choose to publish the latest research data on ASCO. On the last day of ASCO in 2017, the legendary creature announced the early data of the self-developed CAR-T product LCAR-B38M (R&D code of Sida Giorense) to the pharmaceutical industry peers and experts around the world.

According to the report of Zhao Wanhong, the research organizer and deputy director of the Department of Hematology, the Second Affiliated Hospital of Xi ‘an Jiaotong University, among the 35 patients with recurrent multiple myeloma who were treated by CART, 33 (94%) got clinical remission 2 months after treatment, and the objective remission rate was 100%.

In addition, among the 19 patients who received treatment at the earliest time, 14 patients achieved strict complete remission, 1 patient achieved partial remission, and 4 patients achieved excellent partial remission. The earliest patients who received treatment have lived for more than one year, and they have reached the living state of healthy people.

It’s not imitation, nor improvement, but the exploration and innovation of a China enterprise in the "no man’s land", so when the data of Xidajiaolun match came out, everyone was surprised.

Fan Xiaohu, chief scientific officer of Legendary Biology, recalled that at that time, "it attracted global attention and (Legendary Biology) became the dark horse of China", and many people in the industry gave him feedback, and many start-ups after 2017 were encouraged.

Followed by a number of international pharmaceutical companies seeking business cooperation, after repeated communication and back tone, Legend finally joined hands with Johnson & Johnson.

In December, 2017, Legendary Bio signed an exclusive global license and cooperation agreement with Johnson & Johnson to jointly develop and commercialize Cedarchiorense. Johnson & Johnson paid Legendary Bio a down payment of $350 million and subsequent milestone payments.

By today’s standards, the down payment of $350 million is not high, but at that time, it was the best condition for China pharmaceutical companies to record the largest amount of down payment for foreign patent authorization and cooperation.

Regarding the cooperation between the two parties, Huang Ying said that Legend’s cooperation with Johnson & Johnson has strengthened the legendary creature’s ability in the process of R&D and registration of Sida Chiolense. From early R&D to late R&D, including clinical, commercial production, GMP production, compliance registration and other processes, the legendary creature’s team actively participated in the whole process, and also cultivated their own ability in the process of learning from Johnson & Johnson.

However, this cooperation model also has shortcomings, "the whole cycle is very long and the investment is very, very large", because Legend’s investment in the American market is as 50-50 as Johnson & Johnson’s, which is a relatively large financial burden for legendary creatures of innovative pharmaceutical companies.

multiple myeloma

Cedactylorense is a chimeric antigen receptor (CAR) T-cell immunotherapy with two single-domain antibodies targeting B-cell mature antigen (BCMA), which is administered by one-time infusion.

Cedactylorense has been approved by FDA to treat patients with relapsed or refractory multiple myeloma, who have received four or more treatments in the past, including proteasome inhibitors, immunomodulators and anti-CD38 monoclonal antibodies.

Multiple myeloma is considered as an incurable hematological tumor, and it is a malignant disease caused by excessive proliferation of plasma cells in bone marrow. Most patients relapse after initial treatment, and the prognosis is not good after receiving the main drugs such as immunomodulator, proteasome inhibitor and anti-CD38 antibody.

According to the American Cancer Society, in 2022, more than 34,000 people in the United States will be diagnosed with multiple myeloma, and more than 12,000 people will die.

Sundar Jagannath, a professor of hematology oncology at Mount Sinai Medical College and a principal investigator of CARTITUTE-1, said that the treatment process of most patients with multiple myeloma is a cycle of continuous remission and recurrence, and only a few patients get deep remission after last-line treatment. "That’s why I am very excited about the results of CARTITUDE-1 study, which shows that Sidakiorense can provide deep and lasting remission and long-term no treatment even after multi-line treatment.

The approval of Sida Chiolense is not based on the data reported in ASCO in the United States in 2017, but on the key data of a CARTITUDE-1 study. CARTITUDE-1 is an ongoing phase 1b/2, open-label, one-arm, multi-center study, with 100% patients from the United States.

In CARTITUDE-1 study, 97 patients with R/R MM experienced deep and lasting remission, with an overall remission rate (ORR) of 98% and a strict complete response (sCR) of 78%. During the median follow-up of 18 months, the median remission duration (DOR) was 21.8 months.

The incidence of multiple myeloma in China is 2-3 patients per 100,000 people. Although it is lower than that of Caucasian and African people, there are considerable unmet clinical needs because of its large base.

Regarding the listing of this product in China, according to the latest communication between Legend Bio and National Medical Products Administration Drug Evaluation Center (CDE), some patients need to be re-enrolled in clinical trials. Huang Ying said that she would keep in touch with CDE during this period.

Enlightenment of "going out to sea"

The research and development cost of innovative drugs is extremely high, and with the implementation of policies such as domestic centralized procurement and medical insurance negotiation, it is almost impossible to recover the research and development cost in a short period of time after the innovative drugs are listed. Under the circumstance that the cost cannot be covered by a single market, it has become an industry consensus to "go out to sea" and develop the international market.

Compared with biopharmaceuticals, the R&D and production of CAR-T are more complicated. The "Going to Sea" of Sidaji Orense is another innovative drug listed in the United States after Zebutini of Baekje Shenzhou.

But before that, in February, Cinda Bio’s PD-1 product Cindilizumab had just been defeated in the United States. In view of the passing of cindilizumab, FDA experts mainly pay attention to three issues: first, whether the control group selected in clinical trials is reasonable; Second, the clinical trial is only done in China population, is it applicable to American patients? Thirdly, it mainly studies whether the design of the terminal is reasonable.

In Huang Ying’s view, since China joined ICH, the regulatory standards of National Medical Products Administration, China are basically the same as those of FDA, focusing on efficacy and product safety evaluation. "There is not much difference between FDA and CDE standards. There may be slight differences in the number of patients enrolled, the length of follow-up, GMP, production process, quality control and other issues, but for a new drug, efficacy and safety are the gold standards."

However, Huang Ying also believes that for enterprises, there are also places that need special attention, such as whether the experimental population can represent the situation of American patients in the real world when doing clinical trials. In the United States, the Asian population is about 5%. It is difficult to apply for approval with the data of 100% Asian population or Chinese.

One more thing, does the control group designed in clinical trials use placebo or the best treatment standard already available in the market? "CDE has also issued guidelines. Even if you do clinical trials in China in the future, you can’t just use placebos, but you need to use the best standard drugs in the industry as the control standard." Huang Ying said.

Fan Xiaohu, on the other hand, thinks that biomedical enterprises in China should not worry about policy vacillation and payment all day long, or whether the door of the FDA in the United States will be closed. "These don’t need to be overly worried and interpreted, but (what is needed) do their own thing well and do scientific and technological innovation well."

Reporting/feedback

Follow the General Secretary to See China ｜ Nanjing Strong Chain of Smart Grid, Towards a World-class Industrial Cluster

　　Who is stronger in smart grid?

　　In 2021, Jiangsu Nanjing smart grid industry won the advanced manufacturing cluster competition of the Ministry of Industry and Information Technology and became the "national team" of the advanced manufacturing cluster; In 2022, Nanjing launched an action plan to build a 500 billion-level smart grid industrial cluster; In June this year, the Nanjing Action Plan for Promoting a Strong Industrial City (2023— 2025) proposes that by 2025, Nanjing smart grid will become a leading world-class industrial cluster in China. From leading the country to competing for the world, Nanjing has industrial ambitions.

　　Nanrui Group is undoubtedly the flagship of this industrial aircraft carrier. In 2022, the industrial scale of smart grid cluster in Nanjing reached 268 billion yuan, of which Nanrui Group realized operating income of 47.8 billion yuan, up 16.3% year-on-year.

　　On the afternoon of July 6th, General Secretary of Supreme Leader visited Nanrui Group Co., Ltd. in Nanjing. Xinhua News Agency reporter Xie Huanchi photo

　　On the afternoon of July 6th, General Secretary of the Supreme Leader came to Nanrui Group in Jiangning Development Zone, Nanjing for investigation and study, listened to the general introduction of Nanjing’s national advanced manufacturing cluster of smart grid, and looked at the display of independent and controllable technology products of enterprises.

　　A few days ago, People’s Daily reporter walked into Nanrui Group, and the book on the wall of the exhibition hall read the important instructions of the General Secretary during his inspection: "Energy security and safety are related to the national economy and people’s livelihood and cannot be ignored for a moment ‘ The big country ’ " "It is necessary to accelerate the iterative upgrading of key technologies and core products and the empowerment of new technology wisdom to improve national energy security and support capabilities".

　　Heart is "the country’s greatest"

　　Nanrui Exhibition Hall is the first stop for General Secretary of Supreme Leader to visit Nanrui Group. Here we can see the development course of Nanrui Group: it developed from Nanjing Institute of Automation, Ministry of Electric Power, which was established in 1973. Through the continuous efforts of several generations of scientific and technological personnel, it has won 86 national-level scientific and technological awards, and achieved international leadership and independent control in important sectors such as UHV, large power grid security and stability, power grid dispatching automation and relay protection.

　　From lighting the light bulb to lighting the industry, the new power system has developed into a huge and complex industrial system, and its safe and stable operation is a "national power" and a world-class problem. In the exhibition hall of Nanrui, the 10 characters of "Guardian of Safe Operation of Power Grid" are particularly eye-catching. Such confidence comes from the power grid safety and stability device and control system developed by Xue Yusheng team of Nanrui Group.

　　Xue Yusheng, who is 82 years old, is an academician of China Academy of Engineering trained by Nanrui Group. He has been engaged in the research of power system stability theory and power system automation since he studied PhD in 1985. In his view, the "newness" of the new power system lies in the need to adaptively respond to the uncertain state and events in various related fields, and also in meeting the multi-objective optimization needs in different fields, etc. "This requires us to carry out a large number of innovative work at the source and solve problems one by one."

　　However, the process of tackling key problems in scientific research is arduous, not only to sit on the "cold bench", but also to bear the doubts of the industry sometimes. Xue Feng, chief expert of State Grid and director of the system protection laboratory of Nanrui Group, joined the Xue Yusheng team in 1992. He still remembers that Xue Yusheng used "self-knowledge, loneliness" as his motto to encourage the team. Based on the actual needs of the safe and stable operation of the power grid, they simulated various states of the power grid operation, constantly tried various parameters for theoretical derivation, and repeatedly verified the new method.

　　It takes ten years to sharpen a sword, and hard work pays off. Today, the WARMAP system developed by Xue Yusheng team has covered more than 90% of the provincial power grids in China, and established a comprehensive advantage in the field of power outage early warning system for large power grids.

　　In recent years, Nanrui Group has also achieved a gorgeous turn from "following" to "leading" in the UHV field. It is understood that Nanrui Group has broken foreign blockades and achieved international leadership in technologies such as UHV, flexible HVDC transmission, large power grid security and stability, power grid dispatching and relay protection, and its products and services have been delivered to more than 110 countries and regions around the world.

　　"Run one stick after another"

　　The sun is burning outside the window and the indoor atmosphere is warm. Jin Yulong is discussing some key technical difficulties in the research and development of virtual power plant system with his colleagues. Since he joined the Power Grid Application Research and Development Center of Nanrui Research Institute for four years, he has devoted almost all his body and mind to this project.

　　"Virtual power plant is a system that manages and dispatches distributed energy through information technology and intelligent equipment. Although it is characterized by virtuality, its role is really worthwhile." Jin Yulong takes a large-scale commercial complex as an example. During the peak hours of power consumption in summer, the virtual power plant controller can realize minute-level or second-level remote control, and the temperature of the central air conditioner can be raised by 2~3 degrees Celsius, which can effectively reduce the peak load and ensure the safe supply of power.

　　"If we can aggregate more buildings and factories, we can better release the potential of existing electricity and ensure the safety of the power grid without building new power plants." Jin Yulong said that at present, the team has basically formed a set of relatively mature virtual power plant solutions, and related achievements have been demonstrated and applied in Jiangsu, Shanxi, Ningxia and other places.

　　Dedicated to the tide of the times of self-reliance and self-improvement in science and technology, Jin Yulong really felt the message from the Supreme Leader General Secretary "Take ‘ Do one thing in a lifetime ’ Persistence, tackling high-tech problems and achieving a valuable life ". On the afternoon of July 6, in the intelligent manufacturing production area of Nanrui Group, the general secretary asked: "Are you satisfied with working here?" In the unanimous answer, "Satisfied!" in Jinyu Longkou. From the heart. It is understood that as a leader in the young scientific research group, he got the equity incentive last year.

　　"Scientific research is an endless long-distance running, which requires both ‘ Do one thing in a lifetime ’ Persistence, but also through the talent incentive policy to let the scientific research team ‘ Run one stick after another ’ 。” Zhang Yan, deputy director of the human resources department of Nanrui Group, said that they are speeding up the establishment of a capability evaluation system and a performance appraisal system oriented to innovative value, ability and contribution, and taking the lead in creating a multi-medium and long-term incentive "experimental field", thus forming a situation in which young talents are competing with each other.

　　Nowadays, young talents have become a pillar here, and group-level experts under 40 account for more than 65%. Zhang Yan introduced that among the winners of Nanrui Group’s science and technology awards in 2020, the proportion under 40 years old exceeded 60%; Among the "333 High-level Talents Training Objects" selected in Jiangsu Province in 2021, youth accounted for more than 20%; In the past two years, there were 9 candidates selected for the Young Talents Promotion Project of State Grid Corporation and the Young Talents Promotion Project of China Electrical Engineering Society, with young people under 35 accounting for more than 40%.

　　I personally listened to the words of the Supreme Leader General Secretary encouraging young R&D personnel, and Huang Guiyuan was deeply touched after 00. He graduated from Nanjing University with a major in software engineering last year, and is currently engaged in the interface visualization of power dispatching system. "R&D is not a rush, I want to be like the general secretary, ‘ Aim high, be down-to-earth, and move forward step by step ’ . I believe that our young people will be able to provoke the beam of rejuvenating the country through science and technology! " He said.

　　Industrial ambition of gathering potential and strengthening chain

　　During this inspection tour in Jiangsu, the General Secretary of the Supreme Leader entrusted Jiangsu with "four new" major tasks, one of which was "showing new achievements in strengthening the chain and extending the chain".

　　In the past half century, Nanrui Group has developed from a unit with less than 100 employees to a modern enterprise with 14,000 employees. Correspondingly, the smart grid industry in Nanjing has grown from scratch to cluster, with more than 1,200 related enterprises in the city, accounting for 80% of the national market, forming a "one valley and two districts" cluster development pattern with Jiangning Smart Grid Industry Valley as the core and Nanjing Economic and Technological Development Zone and Nanjing Jiangbei New District as the two wings.

　　The national smart grid sees Nanjing, and the Nanjing smart grid sees Jiangning. As early as the "Twelfth Five-Year Plan" period, Jiangning District planned to build a smart grid industrial park of 7 square kilometers. In recent years, it has built 13 state-level technology business incubators and 20 state-level creative spaces, providing an important platform for accelerating the industrialization of new technologies, improving the regional innovation ecology and gathering innovative small and medium-sized enterprises. At present, around Nanrui Group, Jiangning Smart Grid Industry Valley has gathered more than 280 affiliated enterprises, covering nine key links in the industrial chain.

　　"Our main product is power equipment, which is a very critical part of the industrial chain." Huanyu Group (Nanjing) Co., Ltd. settled in Jiangning Binjiang Economic Development Zone in 2009. Fan Jianlun, vice president of the company, said that the company has cooperated with Nanrui Group, Guodian Nanzi, Jinzhi Technology and other companies in Jiangning. "Undoubtedly, a sound local industrial chain has greatly helped our business development."

　　Jiangsu hengan energy storage technology co., ltd. production workshop. Photo by Ren Jiaxuan

　　Jiangsu Hengan Energy Storage Technology Co., Ltd. just settled in Jiangning Development Zone last year. Here, enterprises have found a way from scientific research and development to industrial application. "The process of a project from research and development to mass production is not easy." In the view of Duan Huiyuan, the general manager of the company, the team has been engaged in the research of zinc-bromine flow battery for 17 years and entered the industrialization stage. "If we rely solely on our own strength, it will take a lot of time and capital costs."

　　Duan Huiyuan introduced that when building a new automated production line, they found local equipment provided by Copilon, and Eston provided robots for assembly of production components for the production line. They also sought the research team of Southeast University to jointly solve the problem of improving battery conversion efficiency, and also discussed technical cooperation with Nanrui Group. When they learned that a cooperative enterprise was developing photovoltaic power generation business, they changed from "customers" to "suppliers" to design energy storage power stations for them.

　　"Our first production line took a year and a half from design to commissioning. The new production line here is expected to complete equipment production, installation and commissioning in half a year, and it will be put into production around the Spring Festival next year. " Duan Huiyuan said frankly that the local mature industrial chain "ecological circle" has greatly accelerated the pace of enterprise development.

　　"We have implemented regional dislocation development and continuously optimized the industrial layout. The planned output value of smart grid industry has increased from 67.6 billion yuan in 2018 to 122.7 billion yuan in 2022, with a cumulative increase of 69.8%." The relevant person in charge of Jiangning District Bureau of Industry and Information Technology introduced that Jiangning Development Zone promotes the construction of smart grid industry valley around high quality, and builds the core area of smart grid high-end equipment industry and the source of original technology; Binjiang development zone takes advantage of port logistics and modern equipment manufacturing industry, focusing on introducing equipment manufacturing projects related to the shortcomings of the industrial chain; Other parks and street industrial concentration areas, combined with regional reality, guide the transformation and entrepreneurship of scientific and technological achievements related to smart grid industry.

　　More than a month ago, the smart grid industry multiplication action plan of Jiangning Development Zone was released, the second phase project of Nanrui Jibao Intelligent Electrical Equipment Industrial Park started, and the project of Sunshine Power Nanjing R&D Center was signed and settled; More than two months ago, Nangang’s user-side energy storage power station, known as the "super-large charging treasure", was launched in Jiangbei New District. The industrial layout is steady, major projects are stepped up, and a 500 billion-level smart grid industrial cluster is built. Nanjing is full of horsepower and is determined to win.

Attention, all researchers! The State Council, this document will give you more autonomy, raise funds and reduce approval!

"Now we have to’ decentralize’ more thoroughly and further mobilize the enthusiasm of the majority of scientific researchers!" Premier Li Keqiang on July 4th.The State Council Standing CommitteeIt says.

A few days ago, the State Council issuedNotice on Several Measures to Optimize Scientific Research Management and Improve Scientific Research PerformanceIn the future, researchers will have greater autonomy in how to do scientific research and how to spend funds. How to specify it, the Chinese government website (WeChat ID: zhengfu) and the the State Council client will take you to see it together-

First, scientific researchers have greater decision-making power over the technical route.

■ Reporting period of scientific research projects: based onTechnical route proposed by scientific researchersDemonstrate for the Lord

■ During the implementation of scientific research projects: scientific researchers can, on the premise that the research direction remains unchanged and the reporting indicators are not lowered.Independently adjust the research scheme and technical route, reported to the project management professional institutions for the record.

■ The person in charge of a scientific research project may, according to the needs of the project, comply with regulations.Set up a scientific research team independently, and make corresponding adjustments according to the progress of project implementation.

Two, scientific research units have autonomy in the management and use of scientific research project funds.

■ In addition to the equipment cost, the direct cost,All other subjects’ cost adjustment rights are delegated to the project undertaker.

■ For the project funds entrusted by enterprises or other social organizations,Incorporate into the unified financial management of the unit., managed and used by the project undertaker according to the requirements of the entrusting party or the contract.

■ Universities and research institutes should simplify the procurement process of scientific research instruments and equipment, and adopt the equipment and consumables urgently needed for scientific research.Do special things and do them on call.The procurement mechanism can shorten the procurement cycle without bidding procedures; For the exclusive agent or production of instruments and equipment, according to the procedures to determine the adoption.Single source procurementEqual mode

First, increase the salary incentives for scientific researchers who undertake key technical research tasks in key areas of the country.

■ For team leaders (leading scientists/chief scientists, technical chief engineers, model chief engineers, chief commanders, chief executives, etc.) who undertake tasks full-time and full-time, as well as imported high-end talents, it is implemented.One policy, list management and annual salary system

■ The performance expenditure extracted by the unit from the indirect cost of the key technical research projects in key areas of the country should be paid to those who undertake the task.Young and middle-aged scientific research backbone tilt

■ Increase the incentives for scientific research personnel in universities, research institutes and state-owned enterprises to transform their scientific and technological achievements into equity, and the scientific and technological achievements obtained by scientific research personnel.The converted cash reward is included in the total performance salary of the unit in the current year., but not limited by the total amount, not included in the total base.

Two, to carry out a pilot program to simplify the budget of scientific research projects.

■ In addition to the equipment cost, the direct cost of the project,Other expenses only provide basic calculation instructions, not details.

■ furtherStreamline and merge other direct expense accounts.

■ All project management professional institutions should simplify the budget preparation requirements of relevant scientific research projects.Streamline descriptions and reports

Three, to expand the autonomy of the use of scientific research funds.

■ Pilot units are allowed to steadily support scientific research funds from basic scientific research business expenses and special funds for strategic pilot science and technology of Chinese Academy of Sciences.Withdraw no more than 20% as incentive funds.

■ The scope and standard of use of incentive funds shall be decided by the pilot unit independently within the total performance pay, and publicized within the unit.

■ Intelligence-intensive projects such as basic research, software development and integrated circuit design with low dependence on test equipment and low consumption of experimental materials.Increase the proportion of indirect funds30% for the part below 5 million yuan, 25% for the part between 5 million yuan and 10 million yuan and 20% for the part above 10 million yuan.

■ YesPure theoretical basic research projects such as mathematics, can further adjust the proportion of indirect funds according to the actual situation.

■ The use of indirect funds should be tilted towards teams and individuals with outstanding innovation performance.

Four, to carry out scientific research institutions to support the pilot classification.

For basic frontier research institutions, increase regular funding and other stable support,Appropriately raise the subsidy standard for personnel funds.To ensure reasonable salary and treatment, so that researchers can devote themselves to basic research for a long time.

First, simplify the declaration and process management of scientific research projects

S gradually implement the national science and technology plan annual guide release system on a regular basis, and the guide in advance online publicity, strengthen the project check,Avoid duplicate declaration, increase the preparation time for scientific research personnel to declare

■ Streamline the reporting requirements for scientific research projects,Reduce unnecessary application materials.

■ Implement "milestone" management for key nodes,Reduce all kinds of evaluation, inspection, spot check, audit and other activities during the implementation cycle of scientific research projects.

■ Free exploration basic research projects and implementation cycleFor projects under three years, the self-management of the undertaking unit is the main task., generally do not carry out process inspection.

Two, the merger of financial acceptance and technical acceptance

A one-time comprehensive performance evaluation will be conducted by the professional organization of project management in strict accordance with the task book at the end of the project implementation, and separate financial acceptance and technical acceptance will no longer be carried out.

Three, the implementation of "materials submitted at a time"

■ Integrate the work of science and technology management and the related links of material submission of plan management to realizeMulti-purpose of one meter

■ All materials that have been provided by the national science and technology management information system or have been requested,Repeated provision shall not be required.

■ Simplify statements and processes, speed up the establishment and improvement of academic assistant and financial assistant systems,It is allowed to purchase professional services such as accounting, the scientific research personnel from statements, reimbursement and other specific affairs.

Fourth, avoid repeated multi-head inspection

■ Make a unified annual supervision and inspection plan, and carry out joint inspections at relatively concentrated time to avoid the same project in the same year.Repeated inspection and multi-head inspection

■ Explore the implementation of "double random and open" inspection methods, make full use of information technologies such as big data to improve the efficiency of supervision and inspection, and implement information sharing and mutual recognition of supervision and inspection results.Minimize interference with scientific research activities.

Health and Wellness Committee： Carry out the pilot work of ＂Nursing Service in internet plus＂

Notice of the General Office of the National Health and Wellness Committee on the Pilot Work of "Nursing Service in internet plus"
Guo Wei Ban Yi Han [2019] No.80

Health and Health Committees of all provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps (Health and Family Planning Commission):

In order to implement the Opinions of the General Office of the State Council on Promoting the Development of "Internet+Medical Health" (Guo Ban Fa [2018] No.26), implement the Guiding Opinions on Promoting the Reform and Development of Nursing Service Industry by 11 departments including our Committee, standardize "internet plus Nursing Service", ensure medical quality and safety, and help implement the strategy of healthy China, through research, our Committee has determined Beijing, Tianjin, Shanghai and Jiangsu. Other provinces select pilot cities or regions to carry out pilot work according to the actual situation in the region. The pilot work plan is hereby printed and distributed to you, please formulate the implementation plan according to the actual situation.

The pilot provinces shall submit the implementation plan before February 25, 2019. All relevant provinces should earnestly strengthen their leadership, seriously organize the implementation in light of the actual situation, and submit the summary of the pilot work (including the implementation plan, the list of pilot medical institutions, and the policy documents formulated and promulgated) to the Medical Administration and Hospital Authority of our Committee before the end of December 2019.

Contacts: Yang Wei, Li Meng, Nursing and Rehabilitation Department of Medical Administration Hospital Authority.

Tel: 010-68791850, 68792208.

Fax: 010-68792959

Email: HLKFC@nhfpc.gov.cn

General Office of National Health and Wellness Commission
January 22, 2019

(Information disclosure form: voluntary disclosure)

"internet plus Nursing Service" Pilot Work Plan

"Nursing service in internet plus" mainly refers to the nursing service provided by medical institutions for discharged patients or special people who suffer from diseases and have difficulty in moving, relying on information technology such as the Internet and taking "online application and offline service" as the main mode. In order to standardize and guide the healthy development of "Nursing Service in internet plus" and further ensure the quality and safety of medical care, this pilot scheme is formulated according to the Regulations on the Administration of Medical Institutions, the Regulations on Nurses and other documents, the Opinions of the General Office of the State Council on Promoting the Development of "Internet+Medical Health", the Administrative Measures for Internet Diagnosis and Treatment (Trial) and the Administrative Measures for Internet Hospitals (Trial).

I. General requirements

(1) Guiding ideology. Guided by Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, fully implement the spirit of the 19th National Congress of the Communist Party of China and the National Health and Wellness Conference, follow the overall requirements of implementing the Healthy China Strategy, focus on "people’s health", closely follow the main contradictions and key issues in the nursing field, highlight shortcomings and strengths, innovate nursing models, expand service supply, improve service efficiency, standardize service behavior, ensure quality and safety, and accurately meet the diverse and multi-level health needs of the people.

(2) Work objectives. After a year’s trial, under the background of "Internet+medical health", we explored the management system, service model, service standard and operation mechanism of "internet plus Nursing Service" which is suitable for China’s national conditions. Give full play to the demonstration role of the pilot areas, form reproducible and beneficial experiences, gradually promote them from point to area, and standardize and guide the healthy development of "Nursing Service in internet plus". The supply of nursing services has been further expanded, and the people’s sense of acquisition has been significantly enhanced.

Second, the basic principles

(a) to carry out and standardize services according to law. "Nursing service in internet plus" should be based on the requirements of relevant laws and regulations, adhere to the principle of "online and offline, homogeneous management", ensure the standardized development of relevant services, and guarantee the medical quality and safety and the legitimate rights and interests of both nurses and patients.

(B) people-oriented, to meet the needs. Fully consider the health characteristics of different groups of people and the urgent demand for nursing services, take "people’s health" as the center, coordinate the development of institutional nursing, community nursing and home nursing services, increase the supply of nursing services, and continuously meet the diverse and multi-level health needs of the people.

(3) Encourage innovation and be tolerant and prudent. Innovating nursing service mode and exploring and cultivating new nursing service formats. Encourage social forces to actively participate, follow market rules, and stimulate market vitality. Implement an inclusive and prudent supervision method to effectively ensure quality and safety.

(four) according to local conditions, step by step. Encourage all localities to actively explore, combine local conditions and the characteristics of nursing work, and carry out pilot work scientifically, steadily and step by step. Timely summary, continuous adjustment, and earnestly safeguard the health rights and interests of the people.

Third, the pilot content

(A) a clear "internet plus nursing service" to provide the main body. The health administrative department in the pilot area may, in combination with the actual situation, determine the entity medical institutions that have obtained the Practice License for Medical Institutions and have provided services such as family beds and rounds (hereinafter referred to as "pilot medical institutions"), and rely on the Internet information technology platform to send registered nurses of the institutions to provide "internet plus Nursing Service" to extend the nursing service from the institutions to the communities and families. Registered nurses should have at least five years of clinical nursing experience and technical titles above that of nurses, and can query in the national electronic registration system for nurses. Encourage qualified pilot medical institutions to strengthen the management of nurses through face recognition and other human feature recognition technologies, and equip them with nursing recorders. A withdrawal mechanism should be established for nurses who violate relevant laws and regulations and have bad practice records.

(two) clear "internet plus nursing service" service object. Focus on providing chronic disease management, rehabilitation nursing, special care, health education, hospice care and other nursing services for the elderly or disabled elderly, convalescent patients and terminal patients with mobility difficulties. The health administrative departments in the pilot areas can determine the specific service targets of the pilot work of "internet plus Nursing Service" according to the actual situation and the health characteristics of the population and the principles of highlighting key groups, ensuring quality and safety, and preventing and controlling practice risks.

(three) clear "internet plus nursing service" project. The pilot area should be combined with the actual situation, on the basis of investigating and studying the service needs of the masses and fully evaluating the environmental factors and practice risks, organize and formulate the "internet plus Nursing Service" project in this area. In principle, the service items should be technologies with large demand, low medical risk and easy operation and implementation, and the combination of "positive list" and "negative list" can be used to make it clear, so as to effectively guarantee the quality and safety of medical care.

(four) standardize the "internet plus nursing service" behavior. Before providing "internet plus Nursing Service", the pilot medical institutions made the first visit to the applicants, and evaluated their diseases and health needs. If it is considered that "internet plus Nursing Service" can be provided, nurses with corresponding qualifications and technical ability can be sent to provide relevant services. Nurses should strictly abide by relevant laws and regulations, professional ethics and technical operation standards, standardize service behavior, and effectively ensure medical quality and safety. The data generated in the service process should be traced all the way, which can be queried and traced to meet the regulatory needs of the industry.

(5) Improve the management system and service standard of "internet plus Nursing Service". The health administrative departments in the pilot areas and the pilot medical institutions should establish and improve the relevant management systems and service specifications of "internet plus Nursing Service" in accordance with the relevant national management regulations and technical specifications, such as nursing management system, medical quality and safety management system, medical risk prevention system, medical document writing management regulations, personal privacy protection and information safety management system, medical waste disposal process, home care service process, dispute complaint handling procedure, adverse event prevention and disposal process, relevant service specifications and technical guidelines.

(six) to strengthen the management of Internet information technology platform. Pilot medical institutions can independently develop Internet information technology platforms or establish cooperation mechanisms with qualified third-party information technology platforms. Internet information technology platform should have the equipment and facilities, information technology, technical personnel, information security system, etc. required to carry out "internet plus Nursing Service". The basic functions at least include the identity authentication of clients, the collection and storage of medical records, the positioning and tracking of service personnel, the protection of personal privacy and information security, the traceability of service behavior throughout the process, and the statistical analysis of workload. Do not buy or sell or disclose personal information.

(seven) clear "internet plus nursing service" related responsibilities. Pilot medical institutions and third-party Internet information technology platforms shall sign cooperation agreements, in which their respective responsibilities and rights in medical services, information security, privacy protection, nurse-patient safety and dispute settlement shall be clearly defined. When implementing "internet plus Nursing Service", a pilot medical institution shall sign an agreement with the client, and inform the patient of the service content, process, responsibilities and rights of both parties and possible risks in the agreement, and sign an informed consent form.

(eight) actively prevent and deal with the risk of "nursing service in internet plus". Pilot areas and pilot medical institutions should sum up the experiences and practices of "internet plus Nursing Service" in some places, and learn from the risk prevention and safety management measures of other industries in internet plus. You can ask the client to upload identity information, medical records, family signing agreements and other materials for verification; Requirements for the qualification, service scope and project content of nurses providing "internet plus Nursing Service"; Internet information technology platform can purchase/share personal identity information of public security system or compare and verify it through human feature recognition technology such as face recognition; Pilot medical institutions or Internet information technology platforms shall, in accordance with the requirements of the agreement, provide mobile APP positioning and tracking systems for nurses, configure nursing work recorders, make the whole service traces traceable, equip with a one-button alarm device, and purchase liability insurance, medical accident insurance and personal accident insurance, so as to effectively protect nurses’ professional safety and personal safety and effectively prevent and deal with risks. It is necessary to establish a medical dispute and risk prevention mechanism and formulate an emergency response plan. At the same time, open channels for complaints and comments, accept social supervision, and safeguard people’s health rights and interests.

(nine) the establishment of "internet plus nursing service" price and payment mechanism. The pilot area should combine the actual supply demand, give play to the market bargaining mechanism, refer to the local medical service price charging standard, and comprehensively consider the factors such as transportation cost, information technology cost, technical value of nurses’ services and labor remuneration, and explore the establishment of price and related payment guarantee mechanism.

Four, the pilot area and pilot time

(1) Pilot areas. Beijing, Tianjin, Shanghai, Jiangsu, Zhejiang and Guangdong have been designated as the pilot provinces of "Nursing Service in internet plus". Other provinces selected pilot cities or regions to carry out pilot work according to the actual situation.

(2) Pilot time. February-December 2019.

V. Relevant requirements

(1) Raise awareness and strengthen leadership. Pilot areas and pilot medical institutions should fully understand the importance of standardizing the development of "nursing service in internet plus", take accurately meeting people’s diverse and multi-level health needs as the starting point, take safeguarding people’s health rights and interests and ensuring medical safety as the foothold, strengthen organization and leadership, and make overall coordination and promotion. The health administrative departments in the pilot areas should actively coordinate the relevant local departments to formulate and improve relevant policies and promote the pilot work. Pilot medical institutions should clarify the responsible departments and personnel, improve the relevant management systems, service standards and emergency response plans, and ensure the effective and orderly development of the pilot work.

(two) the pilot first, sum up experience. The health administrative department in the pilot area shall, in conjunction with the relevant departments, formulate the pilot work plan and organize its implementation. Focus on the management system, service model, service standard, risk prevention and control, price payment policy and other aspects of "internet plus Nursing Service", try first, and summarize and popularize useful experience. Grasp the progress of the pilot medical institutions in time to ensure that the pilot tasks are completed on time and with good quality. Find the difficulties and problems in the pilot process, and actively study and solve them.

(3) Strengthen supervision and guard against risks. The administrative department of health in the pilot areas shall, jointly with relevant departments, strengthen the supervision and guidance of "nursing service in internet plus". The administrative department of health shall announce to the public the list of pilot medical institutions that carry out "internet plus Nursing Service", announce the supervision telephone number or other supervision methods, and accept and dispose of the report in time. Give full play to the role of social organizations and strengthen the industry supervision and self-discipline of "internet plus Nursing Service". Pilot medical institutions should establish and improve relevant management systems, and strengthen professional safety education and professional knowledge and skills training for nurses. In accordance with the principle of territorial management, local health administrative departments actively pay close attention to the development of the new format of "internet plus Nursing Service" within their jurisdiction, take effective measures to actively prevent and deal with possible risks, and guide the standardized development of "internet plus Nursing Service".

(four) to increase publicity and correct guidance. Health administrative departments in pilot areas and pilot medical institutions should strengthen publicity and training, and positively guide public opinion. Using new media and traditional media such as Internet, newspapers, television and radio, we will widely publicize the significance of carrying out "internet plus Nursing Service" according to laws and regulations, further safeguard people’s health rights and interests and ensure medical safety, and reasonably guide social expectations. Strengthen public publicity and education, guide the correct concept of medical treatment, and prevent medical safety risks. At the same time, strengthen the training and education of medical institutions and nurses, improve the understanding of the new format and service mode of "internet plus Nursing Service", strengthen the awareness of professional safety, constantly standardize service behavior, and provide high-quality nursing services for the masses.

HarmonyOS Zhixing made a strong landing at the 2024 Guangdong-Hong Kong-Macao Auto Show with three brands： asking, enjoying and knowing.

On June 1st, 2024, 2024 (28th) Guangdong-Hong Kong-Macao Greater Bay Area Auto Show and China New Energy Vehicle Science and Technology Exhibition officially kicked off. Three brands, AITO Zhijie, STELATO Zhijie and LUXEED Zhijie, owned by HarmonyOS Intelligent Mobility Alliance, gathered together, led by Zhijie S9 and Wenjie New M7 Ultra, and joined hands with the main models of Wenjie New M5, Zhijie S7 and Wenjie M9 to form a brand-new product matrix.

The new family lineup participated in the exhibition, and the guests of "HarmonyOS Zhixing Living Room" gathered.

In May, 2024, HarmonyOS Zhixing delivered 30,578 new cars, which led the development of new energy vehicle market in China and provided strong momentum for China automobile brands to continue to rise.

With the debut of S9, the executive luxury flagship car, and the new M7 Ultra booth of the national SUV, HarmonyOS Zhixing appeared at the Guangdong, Hong Kong and Macao Auto Show with a brand-new family lineup. Yu Chengdong, managing director of Huawei, chairman of BG, and chairman of BU, a smart car solution, visited the "HarmonyOS Zhixing Meeting Room" to interact with actor Janice Man, and invited Yin Tongyue, chairman of Chery Group, and Zhou Hongyi, chairman of 360 Group, to communicate at the Zhixing booth in HarmonyOS. At the same time, Yu Chengdong held a delivery ceremony for Zhou Hongyi’s M9 new car.

HarmonyOS Zhixing’s first executive-class luxury flagship car, Enjoy World S9, opened for booking, with a pre-sale price of 450,000-550,000.

HarmonyOS Zhixing’s first executive luxury flagship car, Enjoy World S9, made a heavy appearance at Guangdong, Hong Kong and Macao Auto Show. The new car is positioned as the flagship car of panoramic wisdom, with extremely low wind resistance ahead of the global mass-produced executive luxury car, and based on Huawei’s intelligent precipitation and ingenious pursuit, it brings users a luxurious experience beyond the traditional in a brand-new space.

During the auto show, Enjoy World S9 brought three car colors, namely Universal Red, Xinghuijin and Gold-plated Black, with the brand-new Xinghe headlights, to show the beauty of the world. In addition, the new car is the first car equipped with streaming media exterior rearview mirror in HarmonyOS Zhixing, which adopts the design concept of Pioneer Technology, with exquisite design and simple shape.

Strong performance does not live up to the name of the flagship, leading the intelligence to reshape the luxury benchmark. Enjoy the surging power of luxury cars, and equipped with the latest Huawei Turing platform, which can calmly cope with all kinds of working conditions and bring users a good driving experience. At the same time, the new car launched HUAWEI ADS 3.0 advanced intelligent driving system, which realized the comprehensive improvement of intelligent driving, intelligent parking and active safety capabilities, and brought a safer, more secure and more free smart travel experience.

The estimated price of Enjoy the World S9 is 450,000-550,000. From now on, users can make reservations at HarmonyOS Zhixing applet and Huawei Mall, and enjoy double the intention money (5,000 yuan is worth 10,000 yuan, and the deposit can be refunded at any time before locking the order), priority delivery, priority experience and special invitation. It is reported that Enjoy World S9 will be officially listed in Beijing in August.

The national SUV is upgraded again, and the price of the new M7 Ultra in the world is 289,800.

On May 31st, 2024, the new M7 Ultra was officially launched, with a price of 289,800-329,800. The national SUV has ushered in four major upgrades of "extraordinary driving control, extraordinary safety, extraordinary wisdom and extraordinary space", bringing users a more extreme smart travel experience.

This year’s Guangdong, Hong Kong and Macao Auto Show, the new M7 Ultra in the world met the public for the first time. The new car adopts a brand-new family front face design, comes standard with 20-inch double seven-spoke star wheels, and adds star blue body color and red tea orange interior to show texture and luxury. Brand-new Shu Yun seats and star-ring scatterers bring millions of luxury car-class "concert halls" enjoyment. Upgrade the flagship 192-line lidar for more accurate detection and faster response. Huawei’s advanced intelligent driving and omni-directional anti-collision capabilities have advanced, achieving "no one has me, and people have me." The chassis suspension is upgraded with CDC continuous variable damping shock absorber, and the damping of the shock absorber is automatically adjusted in conjunction with ADS road preview, which makes the driving experience further. The new M7 Ultra sold well as soon as it went on the market, and it was set to exceed 6,000 units in one hour, and it was officially delivered in batches on June 2. Make a decision before June 30, and you can enjoy the car purchase rights with a maximum value of 35,000 yuan.

The new M5 is the first smart SUV that is more suitable for young people because of its superior price/intelligence ratio.

The new M5 of Gaoyan urban performance SUV was unveiled at this auto show. Since it was released one month ago, the number of new M5 has exceeded 20,000. Relying on the unique sports aesthetics, two new car colors, Tahiti Grey and Metropolitan Red, and the RS Obsidian sports kit, the new M5 in the world is very popular among young users. Attractive outside and powerful inside, the new M5 comes standard with Huawei’s advanced intelligent driving, upgraded with more reliable omni-directional anti-collision, and has a 1440km long battery life and an all-aluminum chassis, which is a good car worthy of starting with a class of 250,000.

Intellectual S7, redefining young choices.

HarmonyOS Zhixing’s First Smart Car — — With superhuman wisdom, leapfrog performance, all-round space and efficient form, Zhijie S7 meets the diverse needs of young people and redefines young choices. At this auto show, Zhijie S7 was unveiled with two stylish color-changing films, Romanji Red and chansons Green. Romanji Red originated from the color of red wine, and chansons Green is the same as HUAWEI Pura70 series. The color pays tribute to artistic aesthetics and is deeply loved by young users, especially fashionable female users.

Zhijie S7 is equipped with HUAWEI ADS 2.0 advanced intelligent driver who can enjoy the car as soon as you pick it up. It has omni-directional anti-collision system, Huawei Turing platform, 855km ultra-long pure battery life and rapid recharge, all-round large space, HarmonyOS cockpit 4.0 and large model art, and has super scientific and technological strength.

At the same time, Zhijie S7 has become the Top3 sales volume of 300,000 yuan+grade pure electric cars in April. Now, a 0 down payment car purchase scheme with lower annualized rate is introduced: 0 down payment with ultra-low interest rate, and the annualized rate is 1.99%. Compared with the original annualized rate of 2.99%, take the purchase of Zhijie S7 Max Rear Drive Changhang Zhijia Edition as an example. The down payment is 0, and the loan amount is calculated as 269 in 800 yuan, with a net interest saving of 13 in 490 yuan, and the daily payment is only 165 yuan. You can enjoy the rights and interests with a maximum value of 46,000 yuan immediately, and give away a cool summer sunscreen suit (heat insulation film+skylight ice armor) with a limited time of 6,000 yuan.

Ask M9 hard core technology,Reshape the new pattern of luxury car market

Panoramic wisdom flagship SUV M9 continues to exert its strength in the high-end luxury car market. In May, it delivered 15,873 new cars, and topped the sales list of luxury cars of more than 500,000 regardless of energy form for two consecutive months, with a cumulative breakthrough of 90,000, reshaping the new pattern of luxury car market and becoming the focus of this auto show.

Ask the M9 to fully get on Huawei’s top ten smart cars with black technology, Turing chassis, Xuanwu body, full 10 screens, etc., bringing the hard-core strength of the leading generation such as intelligent cockpit, intelligent driving, intelligent safety, etc., redefining smart car standards and creating a smart travel experience that subverts imagination for users.

Thanks to Huawei’s technology accumulation in the ICT field for more than 30 years, and Huawei’s excellent experience in quality control, sales service and brand marketing accumulated in consumer business for more than 10 years, HarmonyOS Zhizhi partners have achieved continuous empowerment of business success. By continuously enriching the matrix of high-end intelligent products, it will bring users a safer, smarter and more convenient ultimate travel experience.

From June 1st to June 9th, 2024, we sincerely invite you to come to Booth 2-03, Hall 2 of Shenzhen International Convention and Exhibition Center (Baoan) to experience the latest products of HarmonyOS Zhixing and appreciate the charm of smart travel at close range.

Focus interview： watching the river gallop and telling the story of China

　　Cctv news(Focus interview): "A big river has wide waves, and the wind blows rice and flowers on both sides." I believe everyone is familiar with this song. We have also known the Yangtze River, the Yellow River, the Songhua River and the Pearl River since childhood. The rushing rivers moisten everything, which is the source of life, the key to production and the foundation of ecology. However, in the past, problems such as over-exploitation and ecological environment deterioration were once very prominent. The great river of the motherland, the Supreme Leader General Secretary has always been concerned about it. Since the 18th National Congress of the Communist Party of China, his investigation and research have traveled to the north and south of the great river and up and down the great river. Great changes have taken place in our rivers in the past ten years. Where does it change?

　　From October 1 ST to 7 th, focusing on ten rivers, such as the Yangtze River, the Yellow River, the Songhua River, the Liaohe River, the Huaihe River, the Pearl River, the Minjiang River, the Tarim River, the Wanquan River and the Beijing-Hangzhou Grand Canal, the central major media reported one by one, showing the magnificent natural picture of the rushing rivers and the lives of the people who live and work in peace and contentment.

　　Taking rivers as the pulse, the large-scale media coverage of CCTV reported that "Rivers Pentium to See China" comprehensively used various forms of expression, leading viewers and netizens to approach rivers.

　　Air, land and underwater, all-round, multi-angle, and accompanying, "Rivers Rushing to See China" first shows you the beautiful China under the concept of ecological priority and green development.

　　The Pearl River "enters the sea with eight mouths" and connects the world. World-class urban agglomerations in the Pearl River Delta develop along the river, and the estuary of the Pearl River is also one of the fastest and most active areas in China. Here, it is also a national first-class protected animal known as the "aquatic giant panda" — — National Nature Reserve of Chinese White Dolphin.

　　The total area of the reserve is about 4.6 million square meters, including most areas at the estuary. The Pearl River waterway is so busy and the economic value is so high. Can ecology be given priority in the rapid development? How to give priority? On the working boat in the reserve, the reporter took the audience to the scene.

　　Not only during the construction of major national projects such as the Hong Kong-Zhuhai-Macao Bridge, activities that may directly harm or even indirectly affect the Chinese white dolphins are prohibited in the reserve. In the past ten years, the number of Chinese white dolphins here has been increasing, and now there are more than 2,500, making it the region with the largest population of Chinese white dolphins in the world.

　　Not only is the water greener, but under the guidance of the concept of joint protection and coordinated promotion of great governance, the ability to ensure river safety has also been greatly improved.

　　Huaihe River, which spans Hubei, Henan, Anhui, Jiangsu and Shandong provinces, was once a famous "disaster river" in history because of poor drainage in the downstream. Since the 18th National Congress of the Communist Party of China, "unified planning" and "unified governance" have been adhered to. The irrigation and water supply project of diverting water from Huaihe River in the revolutionary old area of Dabie Mountain in the upper reaches of Henan Province has invested more than 5 billion yuan, and the construction lasted for three years, and 70% of it has been completed. The second phase of the downstream Jiangsu and Huaihe waterways started in July this year, which will further greatly enhance the flood discharge capacity of the Huaihe River.

　　Chen Maoshan, director of the Development Research Center of the Ministry of Water Resources, said: "The CPC Central Committee with the Supreme Leader as the core attaches great importance to water conservancy work, especially the General Secretary of the Supreme Leader personally planned and deployed to personally promote the systematic governance of river basins in China. In the past decade, the average annual loss of flood disasters in China has decreased from 0.57% in the previous decade to 0.31%, which is an amazing achievement. "

　　Under the lens of "Rivers Pentium to See China", the picture of green water and green hills, rivers and An Lan, blind date between people and water, and urban water blending is slowly unfolding.

　　In the rolling blue waves, "Rivers Rushing to See China" also shows you the dynamic China of the leaping development of river basins.

　　In addition to busy shipping, featuring green and innovation, relying on rich hydropower resources, Guizhou has built a big data industry; Shanghai, Jiangsu, Zhejiang and Anhui are building a scientific and technological innovation community in the Yangtze River Delta, Fuzhou is developing a digital economy, and all areas along the Yangtze River are seeking higher quality development.

　　Not only do we see the great development of big hubs, big waterways and big cities, but behind the ebb and flow of the tide and the leaping development are fireworks and steaming people’s lives.

　　"Rivers Running to See China" also moves the camera to small villages and towns in the river basin, focusing on the life changes of many ordinary people here and their China spirit.

　　Qikou Town, located in Dashanli, Lvliang, Shanxi Province, is a famous ancient wharf of the Yellow River in Ming and Qing Dynasties. Li Shixi, 68, started as a boatman on the banks of the Yellow River when he was a teenager. When encountering headwinds or rapids, they shouted their trumpets and pulled up step by step with a string on their backs. The hard and thrilling boatman’s life not only trained Lao Li’s ability to fight the wind and waves, but also honed his resolute and courageous character.

　　Later, roads and railways were built, Qikou’s position as a water transportation hub gradually disappeared, the local economy lost its pillar, and Lao Li lost his job, so he took odd jobs to support his family. Until the fight against poverty started, relying on the unique folk customs and the scenery of the Yellow River, the local government decided to take a new path to develop cultural tourism. Lao Li, who refused to admit defeat, took the lead in setting up a homestay.

　　With this spirit, qikou town looks the same every year, not only getting rid of poverty, but also successfully creating a national 4A-level tourist attraction last year. In addition to opening a homestay, Lao Li has also become the inheritor of the intangible cultural heritage of the Yellow River. The ancient town is getting more and more lively, and the days of Lao Li and the villagers are getting more and more prosperous.

　　Vivid figures and stories, in addition to the wonderful reports presented by CCTV, People’s Daily, Xinhua News Agency, Guangming Daily and Economic Daily also published a series of reports, which set off the beauty of the times with the beauty of rivers, reflected the changes of the country with the changes of rivers, and showed the prosperity of the country with the prosperity of rivers, which triggered a warm response from the society.

　　Chen Maoshan said: "This is a vivid education on national conditions and water conditions. It is also a successful attempt to tell the story of China, ecological protection and green development. It is also a perfect presentation of China’s brilliant achievements in river basin management and economic and social development under the guidance of the supreme leader’s ecological civilization thought, water control ideas and river strategy."

　　Rivers are rushing and flowing, and China in the new era is thriving and changing with each passing day. Follow that book "A River Rushing to See China", we can see vibrant China, green China and beautiful China, as well as the effects of ecological management and the grand occasion of economic development in major river basins from south to north, as well as the life picture of people living by the water, living in peace and contentment. The beauty of rivers reflects the beauty of the country, the novelty of rivers and the novelty of the times. From south to north, the rolling rivers are full of the spirit of the new era and the landscape of new life.

According to the news, ZEEKR OS 5.0 was tested in Krypton 001, and the car demonstration flowed out.

On July 4 th, the news said that Krypton 001 was testing ZEEKR OS 5.0, and the car demonstration was exposed.

IT House learned from the video that ZEEKR OS 5.0 will add right navigation map display, HUD navigation map switch, music display cover and lyrics, screen off function, screen projection function, DOW opening warning, sentry mode, etc. The display layout of HUD is optimized, and only road information such as vehicle speed, lane distribution and speed limit is displayed when navigation is not in progress.

It is worth mentioning that the brand Krypton delivered 10,620 vehicles in June, and Krypton 001 won the championship of more than 300,000 pure electric vehicles. The 2023 Extreme Krypton 001 recently launched a limited-time car purchase right, and the WE version presented an optional fund of 28,000 yuan; WE version 86kWh battery upgrade lightning switching intelligent four-wheel drive system; ME version upgrades high-performance air suspension package; YOU version upgrades Z?Sport advanced sports suit, with free charging rights for life/120,000 points.

At the same time,Extreme Krypton 001 OS 4.3 will start full push on July 6.ALC shift lever is open for all users to try in 0 yuan.

BMW i5 Long Life Edition will be available soon, with new configuration and price information exposed.

According to the sales staff of a BMW dealership, the new i5 long-life version (eDrive 40L) is coming soon. This new car will be available in M sports suit and luxury suit, and its maximum power will be increased to 250kW, which is higher than the current 210kW. All models are equipped with 96.96kWh, and the maximum cruising range under CLTC conditions reaches 713km. The price difference between the two power models is 30,000 yuan, and it is estimated that the price of the i5 eDrive40L will start from 469,900 yuan.


The sales staff also mentioned that the cash discount for the full car purchase of the eDrive35L entry version (luxury /M sports suit) is nearly 140,000 yuan, and the price of the naked car after the discount is only 310,000 yuan. In addition, car loans can also enjoy low-interest installments, with a down payment of only 60,000 yuan.

The new car is expected to be equipped with 12.3-inch and 14.9-inch suspended curved dual screens, a surround sound system, a 31-inch BMW suspended giant screen and an embracing interactive light belt. At the same time, it is equipped with the latest iDrive8.5 car system.

In terms of power, the new car is equipped with a driving motor with model HA0001N0, and its maximum power is increased by 40kW compared with the 35L model, and the kerb quality is increased to 2294kg. Under CLTC condition, the cruising range of pure electricity is 686km and 713km respectively.

Fan Bingbing was beaten by his mother when he was young and rebellious, and only took a bath once a week (Photo)






Fan Bingbing childhood







Fan Bingbing and mother


　　Fan Bingbing, who frequently attended charity dinners with his mother and appeared in the media, revealed in an interview with host Li Jing recently that he was often beaten by his mother as a child due to his stubborn temper.


　　Two or three years old can recite children’s songs


　　Although Fan Bingbing has now joined the ranks of domestic first-line actresses, in an interview, Fan Bingbing revealed that he used to be a Cinderella who lived in a bungalow and could only take a bath once a week.


　　Speaking of his rebellious time when he did not listen to discipline, Fan Bingbing lamented "poor parents’ hearts": "I have been learning piano under the guidance of my parents since I was a child, and I have a strong desire to express myself. When I was two or three years old, I begged my mother to tell stories every night, and the next day I repeated the story to my mother again. I think this is my mother’s deliberate attempt to cultivate my language expression ability. When I was two or three years old, I could recite a lot of children’s songs."


　　Disobedient and beaten by mother


　　Since she was a child, she has practiced piano and cultivated her body and mind. Fan Bingbing revealed that her parents had long been conscious of cultivating her into a lady of temperament, but because of her stubborn personality, her mother has also strengthened her discipline. "My mother hit me because she really did it. First, because I have a very skinny personality, and second, because she is more irritable, she picks up whatever she picks up. Five or six clothes racks are stacked together, and they will break when they are smoked. I don’t know if it is inferior or too ruthless, and every time I leave a scar on my body."


Editor in charge: Fan Jing

Triple board! ＂Huawei Auto Concept Stock＂ Sailis： There is a risk of overheating market sentiment

Sanlian Sailis (601127) issued a stock trading risk warning announcement on the evening of October 10. Since August 28, 2023, the company’s stock has risen by 110.42%, the Shenwan Auto Index has risen by 7.28% over the same period, and the Shanghai Composite Index has risen by 0.36% over the same period. The company’s stock short-term increase is higher than that of the industry and the Shanghai Composite Index over the same period, and there is a risk of overheating market sentiment.

Among them, the company’s stock price rose by the limit for three consecutive trading days from September 28, 2023 to October 10, 2023, but the company’s fundamentals have not changed significantly, and there is no major information that should be disclosed. As of the close on October 10, Sailis closed at 67.42 yuan/share, with a total market value of 101.60 billion yuan.

In the announcement, Sailis pointed out the risk of performance fluctuations. In the half year of 2023, the company realized operating income of 11.032 billion yuan, a decrease of 11.14% over the same period of the previous year, and realized net profit attributable to shareholders of listed companies – 1.344 billion yuan. From January to September 2023, the company sold a total of 136,786 vehicles, a year-on-year decrease of 30.65%, of which 68,223 new energy vehicles were sold, a year-on-year decrease of 25.16%.

On the evening of the same day, Sailis issued an announcement on the early return of the proceeds raised by the temporary supplementary working capital.

According to the announcement, the company held the 33rd meeting of the 4th board of directors and the 27th meeting of the 4th board of supervisors on December 5, 2022, and considered and passed the "Proposal on the use of idle proceeds raised temporary supplementary working capital".

According to the capital use plan of the proceeds raised investment project and the construction progress of the project, the company will temporarily supplement the working capital of 2.50 billion yuan of idle proceeds raised in order to improve the efficiency of the use of proceeds raised and reduce the cost of company financing, and the use period shall not exceed 12 months from the date of consideration and approval by the board of directors of the company. After the idle proceeds raised is used to supplement the working capital expires, the company will return it in time. If the use progress of proceeds raised investment projects is required or the use progress of proceeds raised is accelerated, the company will return it in advance in time to ensure the normal operation of the proceeds raised investment project.

As of October 10, 2023, the company has returned the full amount of proceeds raised for temporary supplementary liquidity to the proceeds raised special project account in advance, and the use period has not exceeded 12 months. The company has notified the sponsor and the sponsor representative of the return of the above proceeds raised.

On the evening of October 9, Sailis announced that the stock transaction was abnormal, saying that after self-examination, the company’s current production and operation activities are normal and no major changes have occurred. AITO asked the new M7 was listed and delivered, which aroused attention and heated discussions. In addition, the company did not find media reports or market rumors that may have a significant impact on the company’s stock trading price.

Source: Read and create/Shenzhen Business Daily Comprehensive

Original title: "Triple Board!" Huawei Auto Concept Stock "Cyrus: Risk of Overheating Market Sentiment"

Read the original text