分类： zudao

Recently, National Medical Products Administration official website showed that the application for listing of metformin tablets (Ⅰ), (Ⅴ) and (Ⅴ) submitted by Hunan Huize Biomedical Technology/Hunan Jiudian Pharmaceutical Co., Ltd. was accepted by CDE. On April 11th, Zhejiang Huahai Pharmaceutical Co., Ltd. also submitted the application for listing of metformin tablets (VI) and (V) and was accepted.　

China is the largest country in the world, and the number of patients ranks first in the world. The incidence of diabetes is increasing and showing a trend of younger age.

According to the data of the International Diabetes Federation (IDF), the number of adult diabetic patients in the world reached 537 million in 2021. As the country with the largest number of diabetic patients in the world, the number of diabetic patients in China increased from 90 million to 141 million in the past 10 years (2011 -2021), with an increase of 56%, equivalent to 13% of adults suffering from diabetes, and there are about 72.83 million adults.

As the pathogenesis of type 2 diabetes mellitus (T2DM) is complex, with the progress of the disease, single oral hypoglycemic drugs often cannot maintain ideal blood sugar control for a long time, and there will be many complications. More than 60% of patients need to be combined with other hypoglycemic drugs. Compound hypoglycemic preparation has the advantages of strong efficacy, high safety, convenient use, high compliance and high cost performance, and is widely used at present.

Metformin is suitable for adult patients with type 2 diabetes who are treated with eglinide and metformin hydrochloride. It is a simple compound single-tablet drug. Engelgin belongs to sodium-glucose cotransporter 2(SGLT-2) inhibitor, which can reduce the glucose reabsorption in kidney. Metformin hydrochloride can improve insulin sensitivity by increasing the intake and utilization of peripheral sugar.

The mechanism of the two hypoglycemic components is complementary, which can provide more powerful and lasting blood sugar control, and can reduce the number of tablets taken by patients, thus increasing the compliance of patients, and the improvement of compliance is also helpful to further improve blood sugar control.

The original research of metformin englejing was conducted by Boehringer Ingelheim and Lilly. In 2015, it was approved for listing by the US Food and Drug Administration, and in 2019, it was approved by National Medical Products Administration to enter the domestic market under the trade name of Ou Shuangjing.

In June, 2021, Hangzhou Zhongmei Huadong Pharmaceutical Company’s Metformin Engglinide Tablets (I) was approved to be listed in National Medical Products Administration, becoming the first imitation in China, and was exclusively included in the National Medical Insurance Catalogue Class B through medical insurance negotiation in December of the same year. The medical insurance price was 1.21 yuan/tablet (each tablet contained 500mg of Metformin Hydrochloride and 5mg of Engglinide). At present, Hangzhou Sino-American Huadong Pharmaceutical Co., Ltd. is still the only enterprise in China that has been approved to produce metformin.

According to the IQVIA database, the global sales of metformin Engel in 2020 was 505 million US dollars, an increase of over 30% compared with 2019.

In recent years, the sales scale of oral compound hypoglycemic agents in China is also growing rapidly. According to the data of Minenet, the market of oral compound hypoglycemic agents has increased from 800 million yuan in 2019 to over 2.2 billion yuan in 2021, with the growth rate as high as 58% and 68% in 2020-2021. The market potential of oral compound hypoglycemic agents is exploding.

According to Frost&Sullivan data, the global diabetes drug market will reach 69.7 billion US dollars in 2020, and the Chinese diabetes drug market will reach 63.2 billion yuan. It is expected to reach 100 billion-level market in 2024, and will grow at a high speed with a CAGR of 10.4% from 2020 to 2030. The diabetes field has become a field that major pharmaceutical companies will strive for.

Hypoglycemic drugs are constantly innovating, and they don’t stop rolling up. Take Engelje as an example. At present, there are 5 domestic enterprises with production approval, and 18 enterprises are in the production reporting stage. It should be noted that Engelje tablets have been included in the fourth batch of national adoption in February, 2021, which shows the expectations of enterprises for Engelje tablets. However, judging from the global sales of Engelje (US$ 8.2 billion in 2022), the domestic market is far from saturated (over 400 million yuan in 2021).

Under the condition that the single drug track is crowded, some enterprises began to lay out compound preparations. Since this year, seven enterprises have submitted the application for the listing of metformin engeglinide tablets/sustained-release tablets, plus two in 2021, at present, a total of nine enterprises are in the production reporting stage of metformin engeglinide.

It is worth mentioning that although the sales of metformin monotherapy have declined in recent years, it can still be seen everywhere in the market, especially in pharmacies.

At present, the best-selling hypoglycemic compound preparations in the market are mainly metformin plus another kind of hypoglycemic drugs, such as "metformin+sulfonamide urea derivatives", "metformin +DPP-4 inhibitor" and "metformin +SGLT2 inhibitor". In addition, there are more and more combinations of compound hypoglycemic preparations, such as "SGLT2 inhibitor +DPP-4 inhibitor", which has been reported for production by enterprises.

END Author | Ryan Source | Medicine Chunqiu

CCTV News:On May 17th, the Ministry of Housing and Urban-Rural Development said that together with the General Administration of Financial Supervision and other departments, it will launch a work plan to ensure the delivery of urban commodity housing projects, focusing on enabling ordinary people to get houses that have passed the inspection as scheduled according to the contract, and including more projects in the "white list" to give financing support.

The Ministry of Housing and Urban-Rural Development said that through the work plan, we will fight hard to ensure the delivery of commercial housing projects, prevent the risk of disposal of unfinished projects, promote the timely and quality delivery of projects, and let the people get the houses that have passed the inspection as scheduled according to the contract.

Dong Jianguo, deputy director of the Ministry of Housing and Urban-Rural Development, said: "If it is still impossible to hand over the house by exhaustive means, the judicial approach should be taken. In judicial disposal, the legitimate rights and interests of buyers should also be protected in the first place."

Dong Jianguo said that through the plan, the coordination mechanism of urban real estate financing will be further fully utilized, and more projects will be included in the "white list" to provide financing support. At present, 297 cities at prefecture level and above have established the coordination mechanism of real estate financing. In addition, it is necessary to compact the responsibilities of local governments, real estate enterprises and financial institutions. Local governments should assume territorial responsibility, and promote the cooperation between housing and construction, financial management, public security, natural resources, auditing and other departments and the courts, so as to perform their duties and form a joint force. Real estate enterprises should bear the main responsibility, formulate a "one project, one policy" disposal plan, actively dispose of assets and raise funds from various sources to ensure the timely and quality delivery of projects. Financial institutions should implement the due diligence exemption regulations, so as to "make full use of loans" for eligible projects, speed up the approval and issuance of loans, and support the delivery of project construction.

Ministry of Housing and Urban-Rural Development: Do a good job of ensuring delivery around four key points

The State Council Press Office held a routine briefing on the State Council policy on May 17th. The Ministry of Housing and Urban-Rural Development said that it will do a good job in ensuring the delivery of houses around four key contents.

First, lay a solid foundation for the delivery of commercial housing projects, and prevent the disposal of unfinished risks. In accordance with the principles of marketization and rule of law, we will classify and dispose of commercial housing projects under construction that have been sold but not delivered, promote project construction and delivery, and effectively protect the legitimate rights and interests of buyers. The second is to further play the role of urban real estate financing coordination mechanism to meet the reasonable financing needs of real estate projects. The city government promotes projects that meet the "white list" conditions to "make every effort", and commercial banks "make every effort to lend" to compliance "white list" projects to meet the reasonable financing needs of projects under construction.

Dong Jianguo, Vice Minister of Housing and Urban-Rural Development, said that the third is to promote the digestion of existing commodity housing. The city government insists on "ordering according to needs" and can organize local state-owned enterprises to purchase a part of existing commercial housing at reasonable prices for affordable housing.

In addition, all localities will properly dispose of the revitalized stock of land. At present, the stock land that has not been developed or started and not yet completed will be properly disposed and revitalized through government recovery and acquisition, market circulation and transfer, and enterprises’ continued development, so as to promote real estate enterprises to alleviate difficulties and reduce debts and promote the efficient use of land resources.

State Financial Supervision and Administration: The coordination mechanism of urban real estate financing will be established and improved.

At present, 297 cities at prefecture level and above have established real estate financing coordination mechanisms. On May 17th, the State Financial Supervision and Administration said that it will establish and improve the coordination mechanism of urban real estate financing, continue to adhere to the policy of the city, fully support the financing and completion delivery of the projects that should be continued, earnestly do a good job in ensuring the delivery of houses, and protect the legitimate rights and interests of buyers.

The coordination mechanism of urban real estate financing is mainly to summarize the real estate projects within its jurisdiction and review the "white list" projects according to the conditions and standards. For projects that do not meet the conditions and standards for the time being, it is necessary to urge all parties concerned to intensify rectification and effectively solve the corresponding problems to make them meet the conditions and standards of the "white list" projects.

Xiao Yuanqi, deputy director of the State Financial Supervision and Administration, said that the "white list" was voluntarily declared by the real estate project company, and the districts and counties in the city were pre-examined and put forward the list. The urban coordination mechanism organizes screening and review, and those that meet the conditions and standards are included in the "white list". Those that do not meet the conditions and standards should be rectified to promote problem solving and form a closed-loop management mechanism.

Xiao Yuanqi said that the coordination mechanism of urban real estate financing should be responsible for optimizing the supervision process of pre-sale funds and reasonably confirming the amount of pre-sale supervision funds. At the same time, it is necessary to compact the responsibilities of real estate enterprises and real estate project companies.

Ministry of Natural Resources: Policies and measures such as disposal of idle land will be introduced soon.

The relevant person in charge of the Ministry of Natural Resources said on May 17 that it is ready to introduce policies and measures to properly dispose of idle land and revitalize existing land, and support local governments to properly dispose of idle existing residential land that has been sold by means of recovery and acquisition as appropriate to help enterprises solve their difficulties.

The Ministry of Natural Resources said that idle land should be disposed of in strict accordance with the law, and support for the revitalization and utilization of existing land should be increased. Supporting enterprises to optimize development is mainly to eliminate obstacles to development and construction, reasonably exempt from liability for breach of contract caused by natural disasters and epidemics, and allow enterprises to rationally adjust planning conditions and design requirements according to procedures to better meet market demand.

Liu Guohong, vice minister of natural resources, said that promoting market circulation and transfer is mainly to play the role of the secondary market of land, support advance registration and transfer with mortgage, and encourage transfer or cooperative development. Support local governments to recover idle land at reasonable prices in accordance with the principle of "ordering according to needs" for the construction of affordable housing.

Liu Guohong said that in order to implement the main responsibility of the municipal and county governments, cities and counties are required to establish a coordinated decision-making mechanism to dispose of idle and revitalize existing land and stick to the policy bottom line.

In smart car technology, high-level autonomous driving is a difficult problem that major manufacturers and most Internet giants are trying to overcome. Whoever can take the lead in promoting the landing of advanced autonomous driving technology will be able to take the lead in automobile sales. In the high-order autonomous driving technology, the end-to-end model is the most discussed by all parties.

Compared with the previous model, end-to-end seems to have become the only way for advanced autonomous driving. So what is the end-to-end model? What is the development trend of end-to-end model in China? These problems are worthy of people’s attention.

What is an end-to-end model?

Speaking of the end-to-end model, it is natural to be inseparable from the ChatGPT of this year’s fire. ChatGPT itself is an end-to-end model, that is, by inputting words, customers can get the answers they want.

Whether it’s PPT or video, ChatGPT and other big models may spit it out. In this process, the most critical is the AI model. It can gain insight into users’ needs and produce the content they need.

In the field of autonomous driving, the most famous end-to-end model is Tesla’s FSD V12. The input of this model is all kinds of image data obtained by the camera; The output end is the vehicle control instructions, including steering, acceleration and braking. In the middle, it is a big model that Tesla is proud of.

In the scene of end-to-end model, when the vehicle recognizes some traffic signs or encounters various situations, it will automatically judge according to the past learning situation, instead of looking for a solution to this problem in the code according to various preset preconditions like the traditional model.

What are the advantages of the end-to-end model?

In contrast, in the past, the traditional autopilot model was based on the working conditions set by engineers in advance. The choice of driving behaviors, including lane changing, parking and even overtaking, has been set in advance. This will bring two problems:

Autopilot models are becoming more and more complex. Since each module usually only performs one driving behavior, the automatic driving algorithm needs to include the driving behavior of human drivers as much as possible. Therefore, the code of traditional autonomous driving technology usually has hundreds of thousands of lines of code. This will bring higher and higher requirements for the computing power of smart driving chips. Tesla’s FSD V12 has only 2000 lines of code; While FSD V11 has an astonishing 300,000 lines of code.

Unable to solve the long tail condition. No matter how full the preliminary test and certification are, no autopilot algorithm can say that all the long tail conditions are included. Then once you meet a new long tail working condition, it is very likely that traffic accidents will occur and even life injury accidents will occur.

The best case is that the project operated by GM’s Cruise in California encountered various working conditions that had not been encountered in the previous experimental stage at the beginning of its launch, which led to casualties, forcing the California Highway Bureau to suspend the license of Cruise for a time.

Where is the end-to-end difficulty?

To achieve an end-to-end model, there are two main limiting factors: massive data and large computing power. Only with the blessing of these two factors can the end-to-end model land. In order to make the end-to-end model closer to human drivers, its large model often needs to contain hundreds of millions of parameters. Only with more parameters can the driving characteristics and habits of human drivers be better simulated, and the performance of the model will be better. In these two areas, Tesla has a clear first-Mover advantage.

Not long ago, Tesla just got the certification of domestic data security and privacy protection, and was allowed to enter the government department compound. The reason why Tesla didn’t get the relevant recognition before was that the cameras in each car were collecting all kinds of data in real time and uploading them to the server for training the FSD algorithm.

Looking around the world, Tesla’s newly sold models every year are constantly providing data for the FSD V12 algorithm for the latter to continue to optimize learning.

It is worth mentioning that Tesla’s car also has a "shadow mode". It will compare the deviation between the driving behavior of the owner and the driving behavior determined by the automatic driving system, upload the relevant data together, and also optimize the algorithm.

At the same time, in order to be able to calculate the massive data collected, Tesla also needs a supercomputer center. The core of supercomputing center is the large computing power chip. For this reason, Tesla not only bought a large number of NVIDIA H100 chips, but even developed Dojo chips. The unit price of the former is as high as $35,000, while the investment in research and development costs of the latter is hundreds of millions.

For any enterprise, this is not a small expense. Domestic car companies have basically not been able to develop their own large computing chips. NVIDIA H100 chip has already become a product on the export control list of the United States, and it is difficult for domestic car companies to obtain it.

So is it possible to achieve the end-to-end model with massive data and large computing power? The answer is also no.

From the above description, we can find that the end-to-end model is actually a "black box". If there is an error in the model operation, it is actually difficult for researchers to find out what part of the model is wrong and directly adjust the model.

Theoretically, only through more training, or increasing more parameters and trying to adjust some model parameters can we try to solve the problem. Therefore, whether the autopilot model based on end-to-end technology can finally meet the needs of autopilot technology at the safety level is still very uncertain.

Even so, compared with the traditional autopilot model, the advantages of the end-to-end model are very obvious. Especially when solving the long tail condition, the end-to-end model can give play to the incomparable advantages of the traditional autonomous driving technology model. At present, some new car companies, such as Huawei, Tucki, Weilai and Ideality, have started to introduce the end-to-end model in the domestic market.

Aside from Huawei, which has abundant capital, it is a big challenge for new car companies with limited capital accumulation to balance the input and output returns of end-to-end technology. Not to mention, it is not an easy task to buy large computing chips in China at present.

With the high probability of the end of the year, Tesla FSD V12 will enter the domestic market. What changes will take place in the domestic market structure of autonomous driving technology at that time, which deserves people’s attention.

　　On June 29th, the Political Bureau of the Communist Party of China (CPC) Central Committee held the 21st collective study. When presiding over the study, General Secretary of the Supreme Leader stressed that we should unswervingly uphold and improve the party’s leadership, continue to push forward the new great project of party building, implement the party’s organizational line in the new era, and constantly build the party stronger and stronger. Entering a new era and stepping into a new journey, the great ship China is carrying the dream of the great rejuvenation of the Chinese nation. The unknown front is either surging or dangerous, and only by unswervingly marching forward along the party’s organizational line in the new era can we reach the other side of victory.

　　Adhere to the leadership of the party and keep the "steering wheel" stable.The key to China’s success lies in the Party. From the little red boat carrying the hope of the nation to the great ship carrying the hope of the 1.4 billion people in China, the Communist Party of China (CPC) led the people of China to forge ahead bravely, opened up the road of Socialism with Chinese characteristics, made great strides to catch up with the trend of the times, ushered in a great leap from standing up to becoming rich and then becoming strong, and contributed China wisdom and China’s plan to solving human problems. History and practice have proved that upholding the party’s leadership is the root and lifeline of the party and the country, as well as the interests and happiness of the people of all ethnic groups throughout the country. "A ship without a direction is against the wind in any direction." A new era, a new starting point, the direction of the Communist Party of China (CPC)’s leadership is to run towards victory. Only by adhering to the leadership of the Party, educating and guiding the broad masses of party member cadres to strengthen the "four consciousnesses", strengthen the "four self-confidences", practice the "two safeguards" and consciously maintain a high degree of consistency with the CPC Central Committee in ideology, politics and action can we ensure that the great ship China will always advance in the right direction and sail triumphantly for a better future for the Chinese nation.

　　Strictly organize the system and build a strong"fence"It is more urgent for a ship to wander in the middle. At present, we are at the key point of realizing the first century-long struggle goal and marching towards the second century-long struggle goal. Facing the complex situation and arduous tasks, we must strengthen organizational construction and weave a dense organizational system in order to escort the China ship to sail and sail. It is necessary to scientifically set up complete organizations at all levels, so that the core role of each organization can be fully exerted, and a strong security fence from the central to the local and then to the grassroots level can be built. We should keep pace with the times, plan grass-roots party building work in the new era, highlight the political functions of grass-roots organizations, enhance grass-roots organization, enhance grass-roots organization power, make every level of party organizations have great appeal, cohesion and combat effectiveness, unite every party member, every cadre and every mass around the party organization, and unite the majestic power to meet major challenges, resist major risks, overcome major obstacles and resolve major contradictions. Party committees at all levels should earnestly shoulder the political responsibility of managing the party and the party, and make the work on every front, every field and every link specific and in-depth. Organizations at all levels should be the vanguard and model students who practice the organizational line in the new era, and make new contributions to achieving the goal of "two hundred years" and realizing the Chinese dream of great rejuvenation of the Chinese nation.

　　Strengthen team building and activate"power source"The key to running China well lies in the Party and people. The construction of cadres and talents is a major project for the success or failure of the party’s cause. It is necessary to strengthen the cultivation, selection, management and use of cadres, be good at excavating outstanding cadres from hard front-line and hard-working positions, be diligent in strengthening the training of cadres’ ideological and political ability, dare to encourage and support those who take charge, promote the formation of the correct orientation of "those who are able to go up, those who are excellent will be rewarded, those who are mediocre will go down and those who are inferior will be eliminated", strive to build a loyal and clean cadre team with high quality, and build a backbone for promoting the cause construction of Socialism with Chinese characteristics in the new era. We should firmly establish the concept that talents are the first resource, attach importance to talents with a thirst for talents, cultivate talents with the strategy of building nests and attracting phoenix, gather talents and retain talents with the heart of all rivers, further deepen the reform of the system and mechanism of talent development, improve the talent service guarantee system, pay attention to the guidance of talents, create a strong atmosphere of knowing, loving and respecting talents in the whole society, gather all kinds of talents to contribute their talents and make great achievements together, and stimulate the "power source" to promote the voyage of China’s great ship.

　　The blueprint has been drawn and the goal is clear. I believe that as long as we work together and sail along the organizational line of the new era, the China ship will surely sail to a better tomorrow and the Chinese dream of the great rejuvenation of the Chinese nation will surely be realized. (Author: Deng Shaofen)

　　Jin Yang Network News reporter Tang Heng and correspondent Airport Xuan reported: Have you seen the automatic security check? On 25th, Baiyun Airport opened a "self-service intelligent channel" in Terminal 1 security area B, which is the first security channel in China to integrate all self-service equipment into the same channel, which means that China civil aviation security is about to enter a new stage. Yangcheng Evening News reporter learned that the self-service intelligent security inspection channel will save more time for passengers. It is estimated that each intelligent channel will be able to check 20%-30% more passengers every day.

　　The passage is located in the No.9 passage in the security check area B of the departure hall on the third floor of the T1 terminal of Baiyun Airport. It is self-help and intelligent all the time, and the passage is also equipped with a "re-inspection robot". Passengers can successfully pass through two self-service gates with their boarding pass (including electronic boarding pass) and ID card. The system automatically compares the passenger’s identity information with the ticket information, which takes less than 10 seconds to add up, saving half the time compared with manual inspection. After passing through the gate, passengers still need to put their belongings in the basket for X-ray inspection, and sensitive items such as computers, iPad and charging treasures need to be taken out separately. Subsequently, passengers can pass through the millimeter-wave security door, and the instrument will automatically scan to determine whether there are foreign objects all over the passenger’s body. If not, passengers can pass quickly; If yes, the approximate location of the item will be marked on the instrument screen, and the security inspector will conduct targeted re-inspection.

　　If there are suspected illegal items in the carry-on baggage, they will be automatically diverted to the unpacking desk by the system, and the security inspector will open the bag for inspection, and then re-examine the relevant items after taking them out.

Deepening Rural Reform and Promoting Agricultural Modernization —— Interview with Minister of Agriculture Han Changfu

Xinhua News Agency, Beijing, May 31st (Reporter Lin Hui)General Secretary of the Supreme Leader recently hosted a rural reform forum in Xiaogang Village, Fengyang County, Anhui Province and delivered an important speech. Han Changfu, Minister of Agriculture, said in an interview with reporters that the important speech of the General Secretary in Xiaogang Village is a strong signal to strengthen agriculture and attach importance to agriculture, and it is also a heavy hammer to speed up rural reform and development, and it is also a horn to promote agricultural modernization, which further strengthens our confidence and determination to promote rural reform, development and stability.

Deepen the reform of rural land system and collective property rights system.

Q:What key points should be grasped in rural reform at present and in the future?

Han Changfu:Reform is the driving force of agricultural and rural development. In accordance with the spirit of the General Secretary’s important speech and the requirements of the central government’s deployment, we should base ourselves on the present and focus on the long-term, and do a good job in deepening the reform of rural land system and rural collective property rights system, which are the key tasks of laying the foundation and managing the long-term.

The main line of deepening rural reform under the new situation is still to deal with the relationship between farmers and land. With the deepening of industrialization and urbanization, the subject of land contracting right and the subject of management right are separated in fact, which puts forward new requirements for the design of land system. Realizing the separation of contracting right and management right is the direction and major innovation of deepening the reform of rural land system, which is conducive to safeguarding and realizing farmers’ rights and interests and stimulating the vitality of rural development. The premise of "separation of powers" is "implementation of ownership". We are studying the problem of stabilizing rural land in contract relationship and keeping it unchanged for a long time, and put forward specific opinions on the contract period and the way of extending the contract after the expiration of the second round. The basis of "separation of powers" is "stable contracting right". By carrying out registration and certification of contracted land, farmers can really eat "reassurance". The core of "separation of powers" is "freeing management rights", and it is necessary to encourage exploration and innovation, respect farmers’ choices, and develop various forms of agricultural moderate scale operations such as land circulation, land trust and land shareholding.

The reform of rural collective property rights system is a major institutional innovation after the rural household contract responsibility system, which takes care of the long-term, fundamental and overall situation. Promoting this reform is conducive to the formation of an innovative and developed rural property rights system, the improvement of the rural basic management system, the promotion of farmers’ property rights and interests, and the sharing of the fruits of reform and development among the broad masses of farmers. According to the requirements of the central authorities, it is imperative to find out the family background and establish the institutional framework. We should pay close attention to the introduction of reform documents and do a good job in pilot projects, actively explore the quantification of shares to collective members and implement the reform of joint-stock cooperative system, promote the construction of a rural collective property right system with clear ownership, complete power, smooth circulation and strict protection, realize the equal exchange of urban and rural factors, and increase farmers’ property income.

Constructing "Three Systems" and Accelerating Agricultural Modernization

Q:What ideas and measures does the Ministry of Agriculture have in promoting agricultural modernization?

Han Changfu:It is necessary to accelerate agricultural modernization by building a modern agricultural industrial system, production system and management system.

First, we must promote the structural reform of the agricultural supply side and build a modern agricultural industrial system. Guided by market demand, optimize, raise and refine agricultural industry. Since last year, the Ministry of Agriculture has deployed the structural adjustment of planting, animal husbandry and fishery. In the next step, we will intensify our work, pay close attention to the implementation of measures, and make a good combination of agricultural structural adjustment.

The second is to strengthen the support of material technology and equipment and build a modern agricultural production system. Arm agriculture with modern facilities, equipment and technical means, develop green production, and improve the level of improved varieties, mechanization, science and technology, informationization and standardization of agriculture.

The third is to develop moderate scale management and build a modern agricultural management system. Promote the common development of family management, collective management, cooperative management and enterprise management, and improve the level of intensification, scale, organization, socialization and industrialization of agricultural management. The key point is to cultivate new agricultural business entities and new professional farmers, develop agricultural producer services, pay close attention to study and improve the support policies for new business entities, explore various forms of moderate scale operations, and solve the problems of "who will plant the land" and low operating efficiency.

Unswervingly adhere to and improve the basic management system in rural areas

Q:What should we focus on in promoting rural reform and development?

Han Changfu:To maintain rural harmony and stability, the first thing is to stabilize the rural basic management system. Rural basic management system is not only the foundation of rural economic system, but also the basis of rural social governance mechanism, which affects the whole body. To deepen rural reform, the biggest policy is to adhere to and improve the basic rural management system and never waver. To insist on the collective ownership of rural land by farmers, the basic position of family management and the stabilization of land contract relationship, these three "hard levers" must be grasped well. In particular, the reform of rural land system must be carried out prudently and steadily. If you can’t see clearly for a while, don’t rush to move, have some historical patience and don’t rush into it. Land is the survival foundation and emotional dependence of farmers, and it is the "lifeblood" of farmers. Only when the rural land contract relationship is stable can people’s hearts be stable. In the reform of rural land system, we must respect the wishes of farmers, do not engage in coercive orders, and ensure that farmers’ rights and interests are not harmed.

To maintain rural harmony and stability, we must stabilize effective rural policies. The policy is stable, the people are stable, and the countryside is stable. It is necessary to continuously increase and improve the support policies, so that farmers can get more benefits and have more "sense of gain". China’s agricultural and rural economic development in the Twelfth Five-Year Plan has created another best period in history, which proves that a series of policies of the central government to strengthen agriculture, benefit farmers and enrich farmers in recent years are effective and must be adhered to for a long time and constantly improved.

To maintain rural harmony and stability, we must also vigorously promote farmers’ employment and income. Increasing farmers’ employment and income is the biggest livelihood in rural areas. Only when farmers have jobs and "money bags" really swell up can rural harmony and stability be based. It is necessary to support farmers’ employment and entrepreneurship, especially the entrepreneurship of returning migrant workers, as the focus of promoting farmers’ income. Broaden the channels for farmers to increase their income, tap the potential of increasing income within agriculture, vigorously develop new industries and formats such as leisure agriculture and e-commerce, cultivate new income growth points, and promote farmers to increase their income continuously and rapidly.

The Beijing News On October 10th, Hurun Research Institute released the 2019 Hurun Report. Among them, Ma Yun became the richest man in China for the third time with a wealth of 275 billion; Ma Huateng’s wealth rose by 20 billion, returning to the second place with 260 billion.

Ma Yun, who just retired at the age of 55, became the richest man in China for the third time this year with a wealth of 275 billion yuan. As of September this year, Alibaba’s market value was 3.3 trillion yuan. In fiscal year 2019, Alibaba achieved revenue of nearly 400 billion yuan, a year-on-year increase of 51%. Ali continued to make a large number of acquisitions this year. For example, in September, it acquired koala, a cross-border e-commerce platform of Netease, for 14 billion yuan and led Netease Cloud Music; In July, it acquired 49% equity of Deyin Derun held by Deyin Holdings, the major shareholder of Shentong Express, at a price of nearly 5 billion yuan. Zhang Yong, the 48-year-old new head of Ali, ranks among the top 1,000 on the list with a wealth of 4.6 billion yuan.

Ma Huateng, 48, ranked second with 260 billion yuan. Tencent achieved a total revenue of nearly 180 billion yuan in the first half of this year, an increase of 18% year-on-year. As of September this year, Tencent’s market value reached RMB 3 trillion, making it the second largest company in China. Since 2008, more than 60 of the 700 enterprises invested by Tencent have been listed successfully, among which Betta and Futu Securities have been listed in the last year. Recently, Ma Huateng said that the investment in Tencent’s western cloud computing data center will exceed 10 billion yuan. Zhang Zhidong, co-founder of Tencent, ranked 13th on the list with a wealth of 105 billion this year.

Editor Wang Yu　

　　Last night, Jewell Company, which is owned by Jay Chou and participated in the investment, announced that it will help to handle all brokerage affairs in Jerry Yan from now on, and Jerry Yan’s agent will be Yang Junrong, who won the red Jay Chou.

　　"Heavenly King’s pet comes out": It hit it off with Jay Chou’s agent.

　　A few days ago, Jerry Yan arrived in Shanghai to shoot the idol drama Tears of Star Heart, which was jointly invested by CCTV and NHK. Yesterday, he spent the whole day filming interior scenes in his hotel, unwilling to accept any media interview about him becoming Jay Chou’s younger brother.

　　Yesterday, the reporter learned from Jewell Company that Jerry Yan and Jay Chou met in 2004. Both of them are members of the Taiwan Province Star Basketball Team, but they are just friends. The willingness of the two sides to cooperate began at the end of last year. After Jerry Yan set up his own business three years ago, he often hesitated in making decisions. The most impressive thing was the recent basketball fire, which finally decided to participate after repeated performances, but it became a supporting role for Show Lo.

　　In fact, Jerry Yan himself realized that his personality was very unfavorable to his development in the entertainment circle, so he decided to find a good agent to help him. At a party last year, Jerry Yan met Yang Junrong, Jay Chou’s agent. At that time, Yang Junrong touched him with a remark, that is, "The heavenly king is a pet", indicating that he respected Jay Chou and let him play according to Jay Chou’s personality. Because Jerry Yan’s difficulty is well-known in the circle, when he heard Yang Junrong’s remarks, he felt that the two sides had similar ideas and began to discuss the possibility of cooperation.

　　Six brokers in three years: the two parties have not officially signed the contract.

　　According to insiders, Yang Junrong was worried at first, because he also knew that Jerry Yan had changed six brokers in three years since he started his own business, so the two sides discussed the cooperation for a long time and reached a consensus only recently. However, the two sides have not signed a formal contract yet, and only a tacit agreement has been established at present. Insiders said that on the one hand, there should be a running-in process to prevent the two sides from breaking up in discord in the future; on the other hand, Jewel Company should also observe whether Jerry Yan can get along with Jay Chou. After all, Jewel has Jay Chou’s investment, and the company has been doing business around him. Now there is another big name, and the company can’t adapt at the moment.

　　It is understood that Jay Chou, who has always been a maverick, is willing to let the company sign Jerry Yan mainly because of his appeal in overseas markets such as Japan and South Korea. In Japan, Jerry Yan has the strongest appeal among Chinese stars. This time, NHK and CCTV co-produced Tears of a Star, and the Japanese first named Jerry Yan to play it. Therefore, Jay Chou hoped that Jerry Yan would help the company expand overseas markets, so when he knew that Yang Junrong intended to sign Jerry Yan, he readily agreed. After all, the joint efforts of the two could better consolidate the two major markets in China.

Editor: Li Dan